The 1998 eruption of Volcµn Cerro Azul in the Galµpagos Islands produced two intra-caldera vents and a flank vent that erupted more than 1.010 8 m 3 of lava. Lava compositions changed notably during the 5-week eruption, and contemporaneous eruptions in the caldera and on the flank produced different compositions. Lavas erupted from the flank vent range from 6.3 to 14.1% MgO, nearly the entire range of MgO contents previously reported from the volcano. On-site monitoring of eruptive activity is linked with petrogenetic processes such that geochemical variations are evaluated in a temporal context. Lavas from the 1998 eruption record two petrogenetic stages characterized by progressively more mafic lavas as the eruption proceeded. Crystal compositions, whole rock major and trace element compositions, and isotope ratios indicate that early lavas are the product of mixing between 1998 magma and remnant magma of the 1979 eruption. Intra-caldera lavas and later lavas have no 1979 signature, but were produced by the 1998 magma incorporating olivine and clinopyroxene xenocrysts. Thus, early magma petrogenesis is characterized by mixing with the 1979 magma, followed by the magma progressively entraining wehrlite cumulate mush.