Towards understanding the multi-orbital quantum antiferromagnetism in iron pnictides, effective spin couplings and spin fluctuation induced quantum corrections to sublattice magnetization are obtained in the (π, 0) AF state of a realistic three band interacting electron model involving xz, yz, and xy Fe 3d orbitals. The xy orbital is found to be mainly responsible for the generation of strong ferromagnetic spin coupling in the b direction, which is critically important to fully account for the spin wave dispersion as measured in inelastic neutron scattering experiments.The ferromagnetic spin coupling is strongly suppressed as the xy band approaches half filling, and is ascribed to particle-hole exchange in the partially filled xy band.The strongest AF spin coupling in the a direction is found to be in the orbital off diagonal sector involving the xz and xy orbitals. First order quantum corrections to sublattice magnetization are evaluated for the three orbitals, and yield a significant 37% average reduction from the Hartree-Fock value.