Fermi level-tuned optics of graphene for attocoulomb-scale quantification of electron transfer at single gold nanoparticles

Xia, Qiuyuan; Chen, Zixuan; Xiao, Pengwei; Wang, Minxuan; Chen, Xueqin; Zhang, Jian‐Rong; Chen, Hong‐Yuan; Zhu, Jun‐Jie

doi:10.1038/s41467-019-11816-3

Cited by 18 publications

(18 citation statements)

References 45 publications

(54 reference statements)

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“…The detailed design of GNS@MSNs-FA/Ly was displayed in Scheme 1 a. Firstly, GNSs were synthesized via a seed-mediated growth method with minor modification [ 42 , 43 ]. Transmission electron microscope (TEM) image (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy

Yang

Liang

et al. 2021

J Nanobiotechnol

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Background Despite advances of surgery and neoadjuvant chemotherapy during the past few decades, the therapeutic efficacy of current therapeutic protocol for osteosarcoma (OS) is still seriously compromised by multi-drug resistance and severe side effects. Amplification of intracellular oxidative stress is considered as an effective strategy to induce cancer cell death. The purpose of this study was to develop a novel strategy that can amplify the intracellular oxidative stress for synergistic cascade cancer therapy. Methods and results A novel nanocomposite, composed of folic acid (FA) modified mesoporous silica–coated gold nanostar (GNS@MSNs-FA) and traditional Chinese medicine lycorine (Ly), was rationally designed and developed. Under near-infrared (NIR) irradiation, the obtained GNS@MSNs-FA/Ly could promote a high level of ROS production via inducing mitochondrial dysfunction and potent endoplasmic reticulum (ER) stress. Moreover, glutathione (GSH) depletion during ER stress could reduce ROS scavenging and further enable efficient amplification of intracellular oxidative stress. Both in vitro and in vivo studies demonstrated that GNS@MSNs-FA/Ly coupled with NIR irradiation exhibited excellent antitumor efficacy without noticeable toxicity in MNNG/HOS tumor-bearing mice. Conclusion All these results demonstrated that GNS@MSNs-FA/Ly coupled with NIR irradiation could dramatically amplify the intra-tumoral oxidative stress, exhibiting excellent antitumor ability without obvious systemic toxicity. Taken together, this promising strategy provides a new avenue for the effective cancer synergetic therapy and future clinical translation.

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Section: Resultsmentioning

confidence: 99%

“…The GNS was prepared using a seed-mediated growth progress with slight modifications [ 42 , 43 ]. Briefly, to prepare the seed solution, 1 mL trisodium citrate solution (38 mM), 0.13 mL HAuCl 4 (0.1 M) and 44 mL deionized (DI) water were mixed at room temperature.…”

Section: Methodsmentioning

confidence: 99%

Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy

Yang

Liang

et al. 2021

J Nanobiotechnol

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show abstract

“…The GNS was prepared using a seed-mediated growth progress with slight modi cations [40,41]. Brie y, to prepare the seed solution, 1 mL trisodium citrate solution (38 mM), 0.13 mL HAuCl 4 (0.…”

Section: Synthesis Of Gnsmentioning

confidence: 99%

“…The detailed design of GNS@MSNs-FA/Ly was displayed in Scheme 1a. Firstly, GNS were synthesized via a seed-mediated growth method with minor modi cation [40,41]. Transmission electron microscope (TEM) image (Fig.…”

Section: Synthesis and Characterization Of Gns@msns-fa/lymentioning

confidence: 99%

Amplification of Oxidative Stress With Lycorine and Gold-Based Nanocomposites for Synergistic Cascade Cancer Therapy

Yang

Liang

et al. 2021

Preprint

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BackgroundDespite advances of surgery and neoadjuvant chemotherapy during the past few decades, the therapeutic efficacy of current therapeutic protocol for osteosarcoma (OS) is still seriously compromised by multi-drug resistance and severe side effects. Amplification of intracellular oxidative stress is considered as an effective strategy to induce cancer cell death. The purpose of this study was to develop a novel strategy that can amplify the intracellular oxidative stress for synergistic cascade cancer therapy.Methods and resultsA novel nanocomposite, composed of folic acid (FA) modified mesoporous silica–coated gold nanostars (GNS@MSNs-FA) and traditional Chinese medicine Lycorine (Ly), was rationally designed and developed. Under near-infrared (NIR) irradiation, the obtained GNS@MSNs-FA/Ly could promote a high level of ROS production via inducing mitochondrial dysfunction and potent endoplasmic reticulum (ER) stress. Moreover, glutathione (GSH) depletion during ER stress could reduce ROS scavenging and further enable efficient amplification of intracellular oxidative stress. Both in vitro and in vivo studies demonstrated that GNS@MSNs-FA/Ly coupled with NIR irradiation exhibited excellent antitumor efficacy without noticeable toxicity in MNNG/HOS tumor-bearing mice.ConclusionAll these results demonstrated that GNS@MSNs-FA/Ly coupled with NIR irradiation dramatically was able to amplify the intra-tumoral oxidative stress, exhibiting excellent antitumor ability without no obvious systemic toxicity. Taken together, this promising strategy provides a new avenue for the effective cancer synergetic therapy and future clinical translation.

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“…As shown in Figure 1A, we observe the structural color scattering from individual microbial cells by using a homemade total internal reflection dark-field microscope. 32 Simply, a collimated white light is directed onto the cover slide via a high numerical aperture oil immersion objective to generate the evanescent field, which is further scattered by microbial cells. The scattering light is directed to a camera to form structural color scattering images.…”

mentioning

confidence: 99%

Label-Free Probing of Electron Transfer Kinetics of Single Microbial Cells on a Single-Layer Graphene via Structural Color Microscopy

et al. 2021

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Studies of electron transfer at the population level veil the nature of the cell itself; however, in situ probing of the electron transfer dynamics of individual cells is still challenging.Here we propose label-free structural color microscopy for this aim. We demonstrate that Shewanella oneidensis MR-1 cells show unique structural color scattering, changing with the redox state of cytochrome complexes in the outer membrane. It enables quantitatively and noninvasive studies of electron transfer in single microbial cells during bioelectrochemical activities, such as extracellular electron transfer (EET) on a transparent single-layer graphene electrode. Increasing the applied potential leads to the associated EET current, accompanied by more oxidized cytochromes. The high spatiotemporal resolution of the proposed method not only demonstrates the large diversity in EET activity among microbial cells but also reveals the subcellular asymmetric distribution of active cytochromes in a single cell. We anticipate that it provides a potential platform for further exploring the electron transfer mechanism of subcellular structure.

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Fermi level-tuned optics of graphene for attocoulomb-scale quantification of electron transfer at single gold nanoparticles

Cited by 18 publications

References 45 publications

Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy

Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy

Amplification of Oxidative Stress With Lycorine and Gold-Based Nanocomposites for Synergistic Cascade Cancer Therapy

Label-Free Probing of Electron Transfer Kinetics of Single Microbial Cells on a Single-Layer Graphene via Structural Color Microscopy

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