Fermented noni (<i>Morinda citrifolia</i> L.) fruit juice improved oxidative stress and insulin resistance under the synergistic effect of Nrf2/ARE pathway and gut flora in db/db mice and HepG2 cells

Zhang, Xuguang; Zhang, Bin; Li, Li; Li, Xiaobao; Zhang, Junqing; Chen, Guang‐Ying

doi:10.1039/d2fo00595f

Cited by 10 publications

(3 citation statements)

References 77 publications

(99 reference statements)

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“…Proteobacteria includes a mass of typical pathogens, such as Salmonella, Shigella, Klebsiella, and pathogenic Escherichia coli that can generate considerable toxins, thereby serving as a momemtous indicator of gut microbiota disturbance and health disorders of animals [44,45]. It has been documented that the expansions of Proteobacteria, Gammaproteobacteria, Enterobacteriales, Enterobacteriaceae, and Escherichia/Shigella in the gut could cause accumulation of lipopolysaccharide, rendering the occurrence of oxidative stress in animals [19,[46][47][48][49]. Herein, we detected negative correlations of the abundances of Proteobacteria, Gammaproteobacteria, Enterobacteriales, Enterobacteriaceae, and Escherichia/Shigella with both intestinal CAT activity and VH, demonstrating that the enrichments of these bacteria in the DON group conduced the simultaneous intestinal oxidative damage of broilers.…”

Section: Discussionmentioning

confidence: 99%

Dietary Catalase Supplementation Alleviates Deoxynivalenol-Induced Oxidative Stress and Gut Microbiota Dysbiosis in Broiler Chickens

Wang

Zhu

Cao

et al. 2022

Toxins

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Catalase (CAT) can eliminate oxygen radicals, but it is unclear whether exogenous CAT can protect chickens against deoxynivalenol (DON)-induced oxidative stress. This study aimed to investigate the effects of supplemental CAT on antioxidant property and gut microbiota in DON-exposed broilers. A total of 144 one-day-old Lingnan yellow-feathered male broilers were randomly divided into three groups (six replicates/group): control, DON group, and DON + CAT (DONC) group. The control and DON group received a diet without and with DON contamination, respectively, while the DONC group received a DON-contaminated diet with 200 U/kg CAT added. Parameter analysis was performed on d 21. The results showed that DON-induced liver enlargement (p < 0.05) was blocked by CAT addition, which also normalized the increases (p < 0.05) in hepatic oxidative metabolites contents and caspase-9 expression. Additionally, CAT addition increased (p < 0.05) the jejunal CAT and GSH-Px activities coupled with T-AOC in DON-exposed broilers, as well as the normalized DON-induced reductions (p < 0.05) of jejunal villus height (VH) and its ratio for crypt depth. There was a difference (p < 0.05) in gut microbiota among groups. The DON group was enriched (p < 0.05) with some harmful bacteria (e.g., Proteobacteria, Gammaproteobacteria, Enterobacteriales, Enterobacteriaceae, and Escherichia/Shigella) that elicited negative correlations (p < 0.05) with jejunal CAT activity, and VH. DONC group was differentially enriched (p < 0.05) with certain beneficial bacteria (e.g., Acidobacteriota, Anaerofustis, and Anaerotruncus) that could benefit intestinal antioxidation and morphology. In conclusion, supplemental CAT alleviates DON-induced oxidative stress and intestinal damage in broilers, which can be associated with its ability to improve gut microbiota, aside from its direct oxygen radical-scavenging activity.

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Section: Discussionmentioning

confidence: 99%

Dietary Catalase Supplementation Alleviates Deoxynivalenol-Induced Oxidative Stress and Gut Microbiota Dysbiosis in Broiler Chickens

Wang

Zhu

Cao

et al. 2022

Toxins

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“…Bioactive peptides from the cartilage protein hydrolysate of Mustelus griseus could protect H 2 O 2 -caused HepG2 cells from oxidative damage by increasing the levels of SOD, CAT, GPx, and glutathione reductase (GSH-Rx) and decreasing the content of MDA [22]. Zhang also reported that fermented noni (Morinda citrifolia L.) fruit juice (FNJ) markedly ameliorated oxidative stress damage by activating or resisting related antioxidant enzymes activities such as SOD, GPx, and MDA in insulin-resistant HepG2 cells [31]. Endogenous antioxidation defense systems that comprise the antioxidation enzyme recovery system and the glutathione system play a pivotal role in the resistance to oxidative stress.…”

Section: Cpw Counteracted the Oxidative Stress And Reinforced Antioxi...mentioning

confidence: 99%

Protective Effect of Chinese Bayberry (Myrica rubra Sieb. et Zucc.) Pomace Wine on Oxidative Stress of Hydrogen Peroxide by Regulating Keap1/Nrf2 Pathway in HepG2 Cells

Jiang

Zhu

Wang

et al. 2023

Foods

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Chinese bayberry (Myrica rubra Sieb. et Zucc.) pomace wine (CPW) is fruity and rich in bioactive compounds, with high nutritional value and antioxidant activities. This study aims to investigate the protective effect of CPW on the oxidative damage induced by hydrogen peroxide in human hepatocellular carcinoma (HepG2) cells and CPW’s possible underlying mechanism. The fluorescence assay results revealed that CPW pre-treatment inhibited intracellular reactive oxygen species (ROS) accumulation in H2O2-induced HepG2 cells and cell membrane injury. Meanwhile, CPW remarkably enhanced the activity of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), and the content of glutathione (GSH). Moreover, CPW pretreatment significantly regulated the expression of Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway-associated genes (Keap1, Nrf2, NADPH quinone oxidoreductase I (NQO1), and heme oxygenase-1 (HO-1)) and its downstream antioxidant genes (SOD, CAT, GSH, and the glutamate-cysteine ligase catalytic (GCLC) subunit) in HepG2 cells. These data demonstrated that CPW prevented H2O2-induced oxidative stress by regulating the Keap1/Nrf2 signaling pathway.

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“…Incorporating probiotic fermented herbs into the diet of grouper may enhance their Growth capacity and anti-oxidation ability, while also decreasing foregut lipase levels (Nie et al, 2022). Furthermore, researchers have revealed that fermented herbs could modify the intestinal oxidative stress and innate immunity in fish by altering the gut microbiota, regulating the gut barrier, and inflammatory response (Zhang et al, 2015;Park et al, 2016;Wang et al, 2021b;Zhang et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

The consumption of fermented Chinese herbs has resulted in better intestinal health and increased resistance to Aeromonas hydrophila in juvenile largemouth bass (Micropterus salmoides)

et al. 2023

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IntroductionThis research aimed to assess the impact of Fermented Chinese herbs (FCHM) on the intestinal barrier, immunity, and protection against Aeromonas hydrophila (A. hydrophila) infection in largemouth bass (Micropterus salmoides).MethodsFour experimental diets were formulated, including H0 (basal diet), H1, H2, and H3, which contained 1%, 3%, and 5% FCHM added to the basal diet, respectively. The fish were randomly allocated to four treatment groups, each with 3 parallel per treatment, consisting of 20 fish per replicate and were raised for 56 days.Results and discussionThe experiment revealed that: compared with the control group, adding 1% FCHM significantly improved the weight gain rate (WGR) and specific growth rate (SGR) of the juvenile largemouth bass (P< 0.05). The ingestion of FCHM substantially elevated the activities of CAT, SOD, GSH-PX, APK, ACP, and LZM, and T-AOC level in the gut region of largemouth bass, while decreasing the MDA content in intestine (P< 0.05). Supplementation with FCHM enhanced the intestinal villus height and relative mRNA expression of intestinal barrier genes ZO-1, Claudin, and Occludin in juvenile largemouth bass. After injecting A.hydrophila, all groups of largemouth bass experienced mortality, but the consumption of FCHM resulted in a decrease in cumulative mortality. After infected with A.hydrophila, the antioxidant enzymes and immune enzymes activities of all test groups were enhanced compared to those before infection, and the antioxidant enzymes and immune enzymes activities of all groups were considerably higher than the control after feeding FCHM (P< 0.05). After infected with A.hydrophila, the intestinal MDA content of largemouth bass was higher compared with that before infection in all cases (P< 0.05), but after feeding FCHM, the MDA content was lower than the control (P< 0.05). Upon consuming FCHM, the mRNA relative expressions of pro-inflammatory biomarkers IL-1β, TNF-α, IL-15 and IL-8 in largemouth bass infected with A.hydrophila were decreased in comparison to the control group. In contrast, the mRNA expression of the anti-inflammatory biomarkers TGF-β and IL-10 were significantly elevated (P< 0.05). In summary, FCHM could improve the intestinal morphology, immunity, and antioxidant capacity of juvenile largemouth bass, and enhance it against A.hydrophila, with a better effect at 1% addition.

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Fermented noni (Morinda citrifolia L.) fruit juice improved oxidative stress and insulin resistance under the synergistic effect of Nrf2/ARE pathway and gut flora in db/db mice and HepG2 cells

Abstract: Oxidative stress interferes with blood glucose homeostasis, leading to insulin resistance (IR) and hyperglycemia, which eventually induces type 2 diabetes (T2DM). Fermented noni (Morinda citrifolia L.) fruit juice (FNJ) is...

Cited by 10 publications

References 77 publications

Dietary Catalase Supplementation Alleviates Deoxynivalenol-Induced Oxidative Stress and Gut Microbiota Dysbiosis in Broiler Chickens

Dietary Catalase Supplementation Alleviates Deoxynivalenol-Induced Oxidative Stress and Gut Microbiota Dysbiosis in Broiler Chickens

Protective Effect of Chinese Bayberry (Myrica rubra Sieb. et Zucc.) Pomace Wine on Oxidative Stress of Hydrogen Peroxide by Regulating Keap1/Nrf2 Pathway in HepG2 Cells

The consumption of fermented Chinese herbs has resulted in better intestinal health and increased resistance to Aeromonas hydrophila in juvenile largemouth bass (Micropterus salmoides)

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