Fermented garlic protects diabetic, obese mice when fed a high-fat diet by antioxidant effects

Jung, Youngmi; Lee, Seon-Ha; Lee, Dong-Sub; You, Myung-Jin; Chung, In Kwon; Cheon, Woo Hyun; Kwon, Youngho; Lee, Young-Joon; Ku, Sae‐Kwang

doi:10.1016/j.nutres.2011.04.005

Cited by 96 publications

(122 citation statements)

References 29 publications

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“…Based on the previous histomorphometrical analysis of metabolic mice (29) or diabetic rats (27,30), adipocyte deposition and hypertrophy, percentages of pancreatic zymogen granule occupied regions, pancreatic islet numbers, and occupied percentages were determined. The mean diameters of epididymal and dorsal abdominal white adipocytes were calculated as an indicator of adipocyte hypertrophy in restricted view fields on a computer monitor using an automated image analysis system (iSolution FL ver.…”

Section: Plasma Insulin Levelsmentioning

confidence: 99%

Anti-obesity and anti-diabetic effects of a standardized potato extract in ob/ob mice

Sung²,

Choung³

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The potato (Solanum tuberosum) has been cultivated globally for food for millenia. Potato contains proteinase inhibitor II, which catalyzes the release of cholecystokinin (CCK), leading to delayed gastric emptying in humans. The present study investigated the anti-obesity effects of Slendesta™ Potato Extract (SLD), a standardized potato extract containing 5% proteinase inhibitor II, in the ob/ob obese mice. Three doses of SLD (50, 150 or 300 mg/kg) were orally administered to ob/ob mice once a day for 28 days, whereas control mice were administered distilled water. Four weeks after SLD treatment, the changes in body weight, food consumption, epididymal fat weight, serum chemistry, insulin, leptin and adiponectin contents, and fat histopathology were determined and compared with ob/ob mice treated with 750 mg/kg conjugate linoleic acid. As a result of SLD treatment in the obese mice, body weight, food consumption, epididymal fat, serum biochemistry, histomorphological changes of fat and pancreas were significantly and dose-dependently decreased compared with ob/ob control mice. These obesity and type 2 diabetes associated alterations were significantly inhibited after SLD treatment for 28 days. Thus, the present results indicate that SLD has potential as an alternative therapeutic agent for obesity.

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Section: Plasma Insulin Levelsmentioning

confidence: 99%

Anti-obesity and anti-diabetic effects of a standardized potato extract in ob/ob mice

Sung²,

Choung³

et al. 2016

Experimental and Therapeutic Medicine

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show abstract

“…Mean diameters (µm) of dorsal abdominal white adipocytes were calculated in restricted view fields on a computer monitor, using an automated image analysis processor. At least 10 white adipocytes per fat pad were used for histomorphometrical analysis according to our previously established methods (43)(44)(45). In addition, total full, mucosa, and epithelial thicknesses of the uterus (µm/uterus) were detected as percentages of uterine glands located in the mucosa (%/mucosa of uterus) using an automated image analyzer.…”

Section: Animals and Husbandrymentioning

confidence: 99%

Anti-climacterium effects of pomegranate concentrated solutions in ovariectomized ddY mice

Kang¹,

Choi²,

Kim³

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. In the present study, the complex anti-climacterium potential of standardized pomegranate concentrated solution (PCS) was investigated using bilateral ovariectomy (OVX) female ddY mice. Changes in body weight and gain during experimental periods, food consumption, serum estradiol levels, total body and abdominal fat densities, abdominal fat pads, and uterus weights were observed, along with the histopathology of abdominal fat pads and uterus for anti-obesity and estrogenic effects. In addition, liver weights, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, and histopathological inspections were performed to explore the hepato-protective effects. Serum total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein, and triglyceride (TG) levels were monitored for hypolipidemic effects with total body and femur mean bone mineral density (BMD), right femur wet, dry and ash weights, strength, serum osteocalcin, bone-specific alkaline phosphatase (bALP) contents, and histological and histomorphometrical analyses for anti-osteoporosis activity. As a result of OVX, notable increases in body weight and gains, food consumption, abdominal fat mass densities, weights of abdominal fat pads deposited in the abdominal cavity, and serum AST, ALT, TC, LDL, TG, and osteocalcin levels were observed, along with decreases in the uterus, liver, and femur weights, mean total body and femur BMD, femur strength, serum bALP, and estradiol levels. In addition, marked hypertrophic alterations in adipocytes located in the deposited abdominal fat pads, liver steatosis, uterine disused atrophic changes, and decreases in bone mass and structures of the femur were also observed in OVX control mice with significant increases in bone resorption markers based on histopathological and histomorphometrical analysis. However, these estrogen-deficient climacterium symptoms were significantly (P<0.05 or P<0.01) inhibited after 84 days of continuous treatment with estradiol and PCS (1, 2 and 4 ml/kg), respectively. The present results suggested that PCS was able to effectively inhibit or refine the climacterium symptoms, including obesity, hyperlipidemia, hepatic steatosis, and osteoporosis, induced by OVX in ddY mice.

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“…Ried et al [18] indicated that aged garlic extract reduced the blood pressure in patients with uncontrolled hypertension. Jung et al [19] indicated that the intake of fermented aged black garlic can be beneficial for the prevention of HFD-induced diabetic complications. However, the literature indicates that the antiobesity effects of black garlic in high-fat diet-fed rats remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Black Garlic Ameliorates Obesity Induced by a High-fat Diet in Rats

Chang¹,

Shiau²,

Cheng³

et al. 2017

JFNR

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Black garlic (also called aged garlic) is a type of fermented garlic product from fresh garlic that is often used as a food ingredient and a functional food in Asian countries. The aim of this study was to investigate whether black garlic ameliorates obesity induced by a high-fat diet in rats. Male Wistar rats were fed a normal diet or a highfat diet (HFD) (30% lard, w/w) combined with 0, 0.2, 0.6, or 1.2% black garlic (BG) (w/w) for a period of six weeks. The results demonstrated that body weight, tissue weights of liver, peritoneal fat, and epididymal fat, serum triglycerides, and hepatic lipid profiles (total lipids, triglycerides, and cholesterol) in the HFD+BG groups were significantly decreased compared with those in the HFD group. BG also reduced hepatic oxidative stress (reduced GSSG and enhanced TEAC, GSH, GRd, and GPx) in HFD-induced obese rats. These results suggest that black garlic may be useful for the treatment of obesity.

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Fermented garlic protects diabetic, obese mice when fed a high-fat diet by antioxidant effects

Cited by 96 publications

References 29 publications

Anti-obesity and anti-diabetic effects of a standardized potato extract in ob/ob mice

Anti-obesity and anti-diabetic effects of a standardized potato extract in ob/ob mice

Anti-climacterium effects of pomegranate concentrated solutions in ovariectomized ddY mice

Black Garlic Ameliorates Obesity Induced by a High-fat Diet in Rats

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