Fermented carrot juice attenuates type 2 diabetes by mediating gut microbiota in rats

Hu, Rongkang; Zeng, Feng; Wu, Linxiu; Wan, Xuzhi; Chen, Yongfang; Zhang, Jiachao; Bin, Liu

doi:10.1039/c9fo00475k

Cited by 60 publications

(48 citation statements)

References 46 publications

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“…Ruminococcaceae have carbohydrate-active enzymes, sugar transport mechanisms, and metabolic pathways for the degradation of complex plant materials [41]. A reduction in Ruminococcaceae UCG-013 has been related to a disrupted carbon metabolism, which means body weight loss in chickens after E. tenella infection [42]. Romboutsia is a recently described bacterial genus that is usually associated with the health status of the gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

Dissection of the cecal microbial community in chickens after Eimeria tenella infection

Chen

Zhao

et al. 2020

Parasites Vectors

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Background: Eimeria spp. are responsible for chicken coccidiosis which is the most important enteric protozoan disease resulting in tremendous economic losses in the poultry industry. Understanding the interaction between the avian cecal microbiota and coccidia is of interest in the development of alternative treatments that do not rely on chemotherapeutics and do not lead to drug resistance. Methods: We utilized 16S rRNA gene sequencing to detect the dynamics of the cecal microbial community in AA broilers challenged with Eimeria tenella. Histopathological analysis of the cecum was also conducted. Results: We found that microbial shifts occur during the infection. Lactobacillus, Faecalibacterium, Ruminococcaceae UCG-013, Romboutsia and Shuttleworthia decreased in abundance. However, the opportunistic pathogens Enterococcus and Streptococcus increased in abundance over time in response to the infection. Conclusions: Eimeria tenella disrupts the integrity of the cecal microbiota and could promote the establishment and growth of potentially pathogenic bacteria. Defining bacterial populations affected by coccidial infection might help identify bacterial markers for intestinal disease as well as populations or species that could be beneficial in maintaining and restoring gut homeostasis during and after infection with E. tenella.

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Section: Discussionmentioning

confidence: 99%

Dissection of the cecal microbial community in chickens after Eimeria tenella infection

Chen

Zhao

et al. 2020

Parasites Vectors

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“…Nevertheless, authors generally agree that fermentation significantly increases the levels of this class of bioactive compounds ( Table 1 ). Different raw materials have been studied, including milk [ 32 , 33 , 34 ], beer wort [ 35 ], fruit [ 36 ] and vegetables [ 2 ], and several bacteria strains have been used for fermentation.…”

Section: Increased Levels Of Scfas In Fermented Foods and Beveragementioning

confidence: 99%

“…Recently, a study reported a significant increase in SCFAs in L. rhamnosus GG -fermented carrot juice, compared with non-fermented ones (unfermented carrot juice: acetate 0.16 ± 0.02 mg/mL, propionate 0.51 ± 0.07 mg/mL, butyrate 0.64 ± 0.11 mg/mL; fermented carrot juice: acetate 0.42 ± 0.05 mg/mL, propionate 0.72 ± 0.09 mg/mL, butyrate 0.995 ± 0.09 mg/mL; p <0.05). Additionallyin this case, the fermentation of dietary fiber was considered as the main mechanism for the increased production of SCFAs [ 2 ].…”

Section: Increased Levels Of Scfas In Fermented Foods and Beveragementioning

confidence: 99%

“…Over time, boththe production and consumption of fermented foods and beverages have strongly increased, due to their peculiar and appreciated taste, and their recognized health benefits. Over the last few decades, scientific research has focused attention on the beneficial properties of fermented foods and beverages, and their impact on human health [ 2 ]. Besides their well-established role on gastrointestinal tract, there is increasing evidence demonstrating that this class of products is able to ameliorate several metabolic outcomes, including glycemia, lipidemia, and oxidative stress, as shown in animal-based in vivo studies [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Fermentation of Foods and Beverages as a Tool for Increasing Availability of Bioactive Compounds. Focus on Short-Chain Fatty Acids

Annunziata

Arnone

Ciampaglia

et al. 2020

Foods

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Emerging evidence suggests that fermentation, historically used for the preservation of perishable foods, may be considered as a useful tool for increasing the nutritional value of fermented products, in terms of increases in bioactive compound content, including short-chain fatty acids (SCFAs), as bacteria end-products, whose beneficial effects on human health are well-established. The purpose of the present manuscript is to summarize studies in this field, providing evidence about this novel potential of fermentation. A limited number of studies directly investigated the increased SCFA levels in fermented foods. All studies, however, agree in confirming that levels of SCFAs in fermented products are higher than in unfermented products, recognizing the key role played by the microorganisms in metabolizing food matrices, producing and releasing bioactive substances. According to the available literature, fermentation might be taken into account by the food industry as a natural strategy with no environmental impacts to produce functional foods and beverages with a higher nutritional value and health-promoting compounds.

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“…According to the latest statistics, the incidence of asthma has been rising in recent decades, with the number of asthma patients increasing from 183 million in 1990 to 242 million in 2013. Infection by pathogenic microorganisms (especially viruses, chlamydia, mycoplasma, and mold) is one of the main causes of severe asthma [ 34 – 37 ]. For example, studies have shown that Proteus accounts for a higher proportion of microorganisms in asthma patients and that Firmicutes are reduced in asthma patients compared to normal people.…”

Section: Resultsmentioning

confidence: 99%

Human Microbe-Disease Association Prediction by a Novel Double-Ended Random Walk with Restart

Wang

Cui

Cao

et al. 2020

BioMed Research International

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Microorganisms in the human body play a vital role in metabolism, immune defense, nutrient absorption, cancer control, and prevention of pathogen colonization. More and more biological and clinical studies have shown that the imbalance of microbial communities is closely related to the occurrence and development of various complex human diseases. Finding potential microbial-disease associations is critical for understanding the pathology of a few diseases and thus further improving disease diagnosis and prognosis. In this study, we proposed a novel computational model to predict disease-associated microbes. Specifically, we first constructed a heterogeneous interconnection network based on known microbe-disease associations deposited in a few databases, the similarity between diseases, and the similarity between microorganisms. We then predicted novel microbe-disease associations by a new method called the double-ended restart random walk model (DRWHMDA) implemented on the interconnection network. In addition, we performed case studies of colon cancer and asthma for further evaluation. The results indicate that 10 and 9 of the top 10 microorganisms predicted to be associated with colorectal cancer and asthma were validated by relevant literatures, respectively. Our method is expected to be effective in identifying disease-related microorganisms and will help to reveal the relationship between microorganisms and complex human diseases.

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Fermented carrot juice attenuates type 2 diabetes by mediating gut microbiota in rats

Cited by 60 publications

References 46 publications

Dissection of the cecal microbial community in chickens after Eimeria tenella infection

Dissection of the cecal microbial community in chickens after Eimeria tenella infection

Fermentation of Foods and Beverages as a Tool for Increasing Availability of Bioactive Compounds. Focus on Short-Chain Fatty Acids

Human Microbe-Disease Association Prediction by a Novel Double-Ended Random Walk with Restart

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