Fermented camel milk prevents carbon tetrachloride induced acute injury in kidney of mice

Abstract

Fermented milk is known to possess potent antioxidant activity. The present study was undertaken to assess the preventive effect of fermented camel milk (FCM) prepared using lactococcus lactis subsp. cremoris against CCl4 induced kidney damage in mice. Nephrotoxicity was induced in mice by a single dose of CCl4 (10 ml/kg 0·3% olive oil, ip). Female mice were pretreated daily with FCM for 15 d. Renal damage was associated with an increase in oxidative stress parameters (lipid peroxidation, protein carbonyl and changes in antioxidant enzyme activities and non-enzymatic antioxidant) and nephropathology markers.The renal injury induced by CCl4 was confirmed by the histological study of the CCl4-intoxicated mice. Pretreatment with FCM significantly prevented renal dysfunction by reducing oxidative stress, while mice recovered normal kidney histology. Moreover, FCM prevented toxicity biomarker changes by reducing creatinine, urea, uric acid, lactate dehydrogenase (LDH) and electrolytes levels in plasma. These data indicate that FCM is efficient in inhibiting oxidative stress induced by CCl4, and suggests that the administration of this milk may be helpful in the prevention of kidney damage.

Incorporation of Sukkari Date in Probiotic-Enriched Fermented Camel Milk Improves the Nutritional, Physicochemical, and Organoleptical Characteristics

“…Fermented milk is currently the most popular commercial functional beverage, and it has nutritional and therapeutic properties [2,5,15,16]. According to WHO recommendations, it contains probiotics, which positively improve human health when consumed regularly [8,11].…”

“…Surprisingly, regular consumption of probiotic-enriched dairy products has been linked to improved health and longevity due to their nutritional and therapeutic properties [12]. Because of its bioactive components and microbial diversity, most studies supported its ability to provide superior benefits and potential therapeutical uses [2,[13][14][15][16][17][18]. Ayyash et al [19] investigated the biological usefulness of the bioaccessible fraction produced in fermented camel milk (FCM) versus fermented bovine milk (FBM) after in vitro digestion.…”

Multi-omics analysis of kidney tissue metabolome and proteome reveals the protective effect of sheep milk against adenine-induced chronic kidney disease in mice

“…Fermented camel milk effectively inhibits oxidative stress induced by carbon tetrachloride and prevents kidney injury. 57 Intervention with camel milk improves cyclosporine-induced nephrotoxicity in rats by inhibiting renal oxidative stress, enhancing antioxidants, and reducing apopto-…”

Nonbovine milk and its products as sources of probiotics delivery: An overview of its viability,functionality and product quality characteristics

“…cremoris can reduce kidney damage in CCl4‐intoxicated mice (Hamed et al . 2018a, 2018b). The CCl4‐intoxicated female mice were pre‐treated with fermented camel milk daily for 15 days.…”

“…Ingestion of fermented camel milk in injured renal mice also presented in positive correlation with the reduction of creatinine, urea, uric acid, lactate dehydrogenase (LDH) and electrolytes levels in plasma (Hamed et al . 2018a, 2018b).…”