Fermentative Succinate Production: An Emerging Technology to Replace the Traditional Petrochemical Processes

Abstract

Succinate is a valuable platform chemical for multiple applications. Confronted with the exhaustion of fossil energy resources, fermentative succinate production from renewable biomass to replace the traditional petrochemical process is receiving an increasing amount of attention. During the past few years, the succinate-producing process using microbial fermentation has been made commercially available by the joint efforts of researchers in different fields. In this review, recent attempts and experiences devoted to reduce the production cost of biobased succinate are summarized, including strain improvement, fermentation engineering, and downstream processing. The key limitations and challenges faced in current microbial production systems are also proposed.

Life cycle assessment of a bioelectrochemical system as a new technological platform for biosuccinic acid production from waste

“…A purification step is required to obtain biomolecules whose purity is close to industrial grade (99.5 %). Like for biosuccinic acid, the purification methods reported in the literature mostly concern biosuccinic acid obtained by fermentation using yeast or bacteria in broth media (Glassner et al 1995;Huh et al 2006;Luque et al 2009;Cao et al 2013). Typically microfiltration and ultra-filtration are used to remove residual cell debris and proteins.…”

“…Another criterion of choice was the advantage for the environmental of local waste-based production. Biosuccinic acid production was chosen for the present study.Biosuccinic acid is produced from the transformation of carbon sources such as glucose and glycerol with yields over 1.1 gram of succinic acid per gram of total sugar(Cao et al 2013; Fung Lam et al 2014;Bretz 2015).…”

Extraction and Esterification of Succinic Acid Using Aqueous Two-phase Systems Composed of Ethanol and Salts

“…Succinic acid was selected as the first target chemical from an initial economic analysis performed by the National Renewable Energy Laboratory, USA [1]. A biotechnological production route for succinic acid has become of interest as a sustainable alternative to the chemical route and already succinic acid produced by fermentation is commercially available [2]. However, its hydrophilicity makes the separation of succinic acid from the fermentation broth difficult.…”

Succinic acid production from cheese whey by biofilms of Actinobacillus succinogenes: packed bed bioreactor tests

“…180 kt SA /y are utilized in the synthesis of new generation renewable polymers such as poly‐1,3‐propylene succinate and polybutyrate succinate (PBS) . The global revenues associated with SA production increased from $183 million in 2010 to an expected $469 million in 2016 …”

“…4 The global revenues associated with SA production increased from $183 million in 2010 to an expected $469 million in 2016. 6 SA is traditionally manufactured through multiple high temperature and high pressure fossil fuel-depending synthetic procedures. The liquid-phase Ni -Pt -Ru -mediated catalytic hydrogenation of maleic anhydride to succinic anhydride, followed by the hydration to succinic acid, is the most direct and widely used reaction.…”