Fermentative production of cycloheximide byStreptomyces griseus andStreptomyces noursei

Abou‐Zeid, A. A.; El-Sherbini, S. H.

doi:10.1002/jctb.5020240413

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Streptomyces species have shown an outstanding capacity for the production of secondary metabolites, many of which effectively can treat human diseases. Secondary metabolites of Streptomyces species belong to different classes of compounds, such as: polyketides [4], peptides [5] and polyketide-peptides hybrids [6], and have been characterized with different biological activities, such as: antibacterial [7] antifungal [8], anticancer [9] and immune suppression [10].…”

Section: Introductionmentioning

confidence: 99%

Different Secondary Metabolite Profiles of Phylogenetically almost Identical Streptomyces griseus Strains Originating from Geographically Remote Locations

et al. 2019

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As Streptomyces have shown an outstanding capacity for drug production, different campaigns in geographically distant locations currently aim to isolate new antibiotic producers. However, many of these newly isolated Streptomyces strains are classified as identical to already described species. Nevertheless, as discrepancies in terms of secondary metabolites and morphology are possible, we compared two Streptomyces strains with identical 16S rRNA gene sequences but geographically distant origins. Chosen were an Easter Island Streptomyces isolate (Streptomyces sp. SN25_8.1) and the next related type strain, which is Streptomyces griseus subsp. griseus DSM 40236T isolated from Russian garden soil. Compared traits included phylogenetic relatedness based on 16S rRNA gene sequences, macro and microscopic morphology, antibiotic activity and secondary metabolite profiles. Both Streptomyces strains shared several common features, such as morphology and core secondary metabolite production. They revealed differences in pigmentation and in the production of accessory secondary metabolites which appear to be strain-specific. In conclusion, despite identical 16S rRNA classification Streptomyces strains can present different secondary metabolite profiles and may well be valuable for consideration in processes for drug discovery.

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Section: Introductionmentioning

confidence: 99%

Different Secondary Metabolite Profiles of Phylogenetically almost Identical Streptomyces griseus Strains Originating from Geographically Remote Locations

et al. 2019

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Bioactive Streptoglutarimides A–J from the Marine-Derived Streptomyces sp. ZZ741

Zhang

et al. 2019

J. Nat. Prod.

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The new streptoglutarimides A−J (1−10) and the known streptovitacin A (11) were isolated from a marinederived actinomycete, Streptomyces sp. ZZ741. Structures of the isolated compounds were elucidated based on their HRESIMS data, extensive NMR spectroscopic analyses, ECD calculations, Mosher′s method, and a single-crystal X-ray diffraction experiment. Streptoglutarimide H (8) and streptovitacin A (11) showed potent antiproliferative activity against human glioma U87MG and U251 cells with IC 50 values of 1.5−3.8 μM for 8 and 0.05−0.22 μM for 11. All isolated compounds exhibited antimicrobial activity with MIC values of 9−11 μg/mL against methicillin-resistant Staphylococcus aureus, 8−12 μg/mL against Escherichia coli, and 8−20 μg/mL against Candida albicans.

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Fermentative production of cycloheximide byStreptomyces griseus andStreptomyces noursei

Cited by 2 publications

References 19 publications

Different Secondary Metabolite Profiles of Phylogenetically almost Identical Streptomyces griseus Strains Originating from Geographically Remote Locations

Different Secondary Metabolite Profiles of Phylogenetically almost Identical Streptomyces griseus Strains Originating from Geographically Remote Locations

Bioactive Streptoglutarimides A–J from the Marine-Derived Streptomyces sp. ZZ741

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