Fermentation process for continuous production of succinic acid in a fibrous bed bioreactor

Yan, Qiang; Zheng, Pu; Tao, Sheng-Tao; Dong, Jing

doi:10.1016/j.bej.2014.08.002

Cited by 25 publications

(18 citation statements)

References 25 publications

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“…Various microbial platforms have been explored for bio-production of SA with the best bench-scale performance achieved by Actinobacillus succinogenes [11][12][13][14], Anaerobiospirillum succiniciproducens [15,16], Mannheimia succiniciproducens [17][18][19], and engineered strains of Escherichia coli [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Continuous succinic acid production from xylose by Actinobacillus succinogenes

Bradfield

Nicol

2015

Bioprocess Biosyst Eng

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) and carbohydrate consumption rates were similar. Also, mass balance closures on xylose were up to 18.2% lower than those on glucose. A modified HPLC method revealed pyruvic acid excretion at appreciable concentrations (1.2 -) which improved the mass balance closure by up to 16.8%. Furthermore, redox balances based on the accounted xylose consumed and the excreted metabolites, indicated an overproduction of reducing power. The oxidative pentose phosphate pathway was shown to be a plausible source of the additional reducing power.

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Section: Introductionmentioning

confidence: 99%

Continuous succinic acid production from xylose by Actinobacillus succinogenes

Bradfield

Nicol

2015

Bioprocess Biosyst Eng

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“…Although a high succinic acid productivity of 8.8 g/L/h was reported, yield of succinic acid was less than 50 % and specific productivity was also very poor [182,183]. Recently, Yan et al determined the optimum operating conditions for succinic acid production using continuous fermentation in fibrous bed bioreactor employing A. succinogenes and achieved succinic acid concentration of 55.3 g/L with a productivity of 2.8 g/L/h [201]. A novel external-recycle, biofilm reactor was used recently to carry out continuous anaerobic fermentation using A. succinogenes and glucose and CO 2 as carbon source.…”

Section: Fermentation Technologiesmentioning

confidence: 94%

Engineered biosynthesis of biodegradable polymers

Jambunathan

Zhang

2016

Journal of Industrial Microbiology and Biotechnology

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Advances in science and technology have resulted in the rapid development of biobased plastics and the major drivers for this expansion are rising environmental concerns of plastic pollution and the depletion of fossil-fuels. This paper presents a broad view on the recent developments of three promising biobased plastics, polylactic acid (PLA), polyhydroxyalkanoate (PHA) and polybutylene succinate (PBS), well known for their biodegradability. The article discusses the natural and recombinant host organisms used for fermentative production of monomers, alternative carbon feedstocks that have been used to lower production cost, different metabolic engineering strategies used to improve product titers, various fermentation technologies employed to increase productivities and finally, the different downstream processes used for recovery and purification of the monomers and polymers.

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“…suggested a possible strategy to avoid growth inhibition and improve the process productivity: the development of a two‐stage process with a first biomass growth phase followed by a SA production phase. Yan et al . studied product inhibition phenomena in a continuous biofilm reactor.…”

Section: Introductionmentioning

confidence: 99%

“…performed batch and fed‐batch fermentations with Actinobacillus succinogenes and glucose and showed that high SA concentrations (98 g L ‐1 ), yields (0.89 g SA g glucose ‐1 ) and productivities (2.77 g L ‐1 h ‐1 ) can be simultaneously achieved in an internal fibrous bed batch bioreactor. In a later study, the same authors reported the results of a continuous process of SA production in a fibrous bed bioreactor . At the optimum operating conditions (glucose 80 g L ‐1 in the feed, dilution rate equal to 0.05 h ‐1 , pH = 6.0–6.5), they obtained 55 g L ‐1 of SA, a 0.80 g SA g glucose ‐1 yield, a productivity equal to that obtained in batch conditions (2.77 g L ‐1 h ‐1 ) and a AA:SA molar ratio of 0.29.…”

Section: Introductionmentioning

confidence: 99%