Fermentation Monitoring and Control: A Perspective

Montague, G.A.; Morris, A.J.; Ward, Alan C.

doi:10.1080/02648725.1989.10647858

Cited by 39 publications

(15 citation statements)

References 86 publications

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“…In such a soft‐sensor robust online measurements, which are not subject to time delay, are used to calculate the expected value of new parameters which are desirable to control, such as biomass, specific growth rate, or oxygen transfer capacity [77, 78]. Soft sensing can also be a tool for industrial application as part of a framework for quality by design (QbD) and PAT principles since it provides a method for on line monitoring of the process [79, 80].…”

Section: Major Challengesmentioning

confidence: 99%

Bis‐arylidene Oxindoles as Anti‐Breast‐Cancer Agents Acting via the Estrogen Receptor

et al. 2014

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We report a new family of bis-arylidene oxindole derivatives that show highly selective estrogen receptor (ER)-mediated anticancer activity at low-nanomolar concentrations in ER-positive (ER+) breast cancer cells. In terms of cell growth inhibition, IC50 values for these compounds in ER+ breast cancer cells are two to three orders of magnitude lower than in ER-negative (ER-) breast cancer cells and non-cancer cells. In comparison with known bis-arylidene drugs, these compounds are at least three orders of magnitude more toxic than tamoxifen and 1.5-4-fold more toxic than 4-hydroxytamoxifen in ER+ MCF-7 cancer cells. These oxindoles inhibit ER transactivation, and their anticancer activities are inhibited in ER-depleted MCF-7 cells. Some of these nonsteroidal molecules also exhibit essential properties of selective ER down-regulation. From the development of two series of bis-arylidene oxindole-based compounds, we report a new series of anticancer agents for estrogen-responsive breast cancer.

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Section: Major Challengesmentioning

confidence: 99%

Bis‐arylidene Oxindoles as Anti‐Breast‐Cancer Agents Acting via the Estrogen Receptor

et al. 2014

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“…This may be most useful in controlling a batch fermentation where considerable and often complex changes may occur (Bull, 1985;Dusseljee and Feijen, 1990). Adaptive control strategies have been used in fed-batch yeast cultivation (Montague et al, 1988), amino acid production (Radjai et al, 1984) and penicillin production (Lorenz et al, 1985). It is also possible to prepare sequential programs using a computer based control system.…”

Section: More Complex Control Systemsmentioning

confidence: 99%

“…This chapter will consider the general types of control systems which are available, specific monitoring and control systems and the role of computers. More information on intrumentation and control has been written by Flynn (1983Flynn ( , 1984, Armiger (1985), Bull (1985), Rolf and Lim (1985), Bailey and Ollis (1986), Kristiansen (1987), Montague et al (1988), Dusseljee and Feijen (1990), Atkinson and Mavituna (1991) and Royce (1993).…”

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confidence: 99%

Instrumentation and Control

Stanbury

1995

Principles of Fermentation Technology

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“…In other studies, the fermenter was supplied with air and the pO 2 was maintained between 0 and 1% by regulating airflow and agitation through cascade control [ 14 ]; alternatively, highly sensitive pO 2 probes were employed for accurate monitoring of absolute values of O 2 in the parts per billion range [ 15 ]. However, using cascade control to maintain pO 2 set-point is likely to cause oscillations in dissolved oxygen concentration resulting in unstable pO 2 in the fermenter [ 16 ]. Therefore, design of methods for growth of MTB in bioreactors must pay particular attention to the stable control of dissolved oxygen concentration.…”

Section: Introductionmentioning

confidence: 99%