Fermentation characteristics and probiotic activity of a purified fraction of polysaccharides from Fuzhuan brick tea

Chen, Guijie; Zeng, Ziqi; Xie, Minhao; Peng, Yujia; Zhou, Wangting; Xu, Weiqi; Sun, Yi; Zeng, Xiaoxiong; Z, Liu

doi:10.1016/j.fshw.2021.12.030

Cited by 22 publications

(8 citation statements)

References 62 publications

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“…Bifidobacteriaceae is the well-known beneficial gut bacteria and is associated with various health-promoting nutritional functions, e.g. , antidiabetes and immunomodulatory effects, , and an important degrader of complex polysaccharides . It has been reported that with the addition of polysaccharides in high-fat diet mice or in vitro fecal fermentation, the relative abundance of Prevotellaceae increased. , Likewise, Prevotellaceae was suggested to contribute to reduce gut dysbiosis in type 2 diabetic mice .…”

Section: Resultsmentioning

confidence: 99%

Soluble, Diferuloylated Corn Bran Glucuronoarabinoxylans Modulate the Human Gut Microbiota In Vitro

Lin

Holck

et al. 2023

J. Agric. Food Chem.

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Corn bran is exceptionally rich in substituted glucuronoarabinoxylan polysaccharides, which are monoferuloylated and cross-linked by diferulic acid moieties. Here, we assessed the potential prebiotic activity of three enzymatically solubilized corn bran glucuronoarabinoxylans: medium feruloylated (FGAX-M), laccase cross-linked FGAX-M (FGAX-H), and alkali-treated FGAX-M devoid of feruloyl substitutions (FGAX-B). We examined the influence of these soluble FGAX samples on the gut microbiome composition and functionality during in vitro simulated colon fermentations, determined by 16S rRNA gene amplicon sequencing and assessment of short-chain fatty acid (SCFAs) production. All FGAX samples induced changes in the relative composition of the microbiota and the SCFA levels after 24 h of in vitro fermentation. The changes induced by FGAX-M and FGAX-H tended to be more profound and more similar to the changes induced by inulin than changes conferred by FGAX-B. The microbiota changes induced by FGAX-M and FGAX-H correlated with an increase in the relative abundance of Anaerostipes and with increased butyric acid production, while the changes induced by the FGAX-B sample were less compelling. The results imply that solubilized, substituted diferuloylated corn bran glucuronoarabinoxylans may be potential prebiotic candidates and that both single feruloylations and diferuloyl cross-links influence the prebiotic potential of these arabinoxylan compounds.

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Section: Resultsmentioning

confidence: 99%

Soluble, Diferuloylated Corn Bran Glucuronoarabinoxylans Modulate the Human Gut Microbiota In Vitro

Lin

Holck

et al. 2023

J. Agric. Food Chem.

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“…Another interesting taxon is M. funiformis, which was significantly decreased in patients with MMD. Some articles reported that M. funiformis was a beneficial bacterium because it was decreased in the elderly 29 and was enriched by a probiotic component of fermented tea 30 , whereas some reported that it is a harmful bacterium because it was associated with metabolic syndrome 31 . Intriguingly, the p.R4810K mutation, a risk factor of MMD and coronary artery disease, was inversely associated with diabetes mellitus 32,33 .…”

Section: Discussionmentioning

confidence: 99%

Increased abundance of Ruminococcus gnavus in gut microbiota is associated with moyamoya disease and non-moyamoya intracranial large artery disease

Mineharu

Nakamura

Sato

et al. 2022

Sci Rep

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Moyamoya disease (MMD) is a rare cerebrovascular disease endemic in East Asia. The p.R4810K mutation in RNF213 gene confers a risk of MMD, but other factors remain largely unknown. We tested the association of gut microbiota with MMD. Fecal samples were collected from 27 patients with MMD, 7 patients with non-moyamoya intracranial large artery disease (ICAD) and 15 control individuals with other disorders, and 16S rRNA were sequenced. Although there was no difference in alpha diversity or beta diversity between patients with MMD and controls, the cladogram showed Streptococcaceae was enriched in patient samples. The relative abundance analysis demonstrated that 23 species were differentially abundant between patients with MMD and controls. Among them, increased abundance of Ruminococcus gnavus > 0.003 and decreased abundance of Roseburia inulinivorans < 0.002 were associated with higher risks of MMD (odds ratio 9.6, P = 0.0024; odds ratio 11.1, P = 0.0051). Also, Ruminococcus gnavus was more abundant and Roseburia inulinivorans was less abundant in patients with ICAD than controls (P = 0.046, P = 0.012). The relative abundance of Ruminococcus gnavus or Roseburia inulinivorans was not different between the p.R4810K mutant and wildtype. Our data demonstrated that gut microbiota was associated with both MMD and ICAD.

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“…These genera selectively promote the degradation of saccharides ( 59 , 60 ) and crude fiber ( 61 ). By reducing intestinal pH and thus limiting the colonization of harmful bacteria that are sensitive to low pH, organic acids created by the fermentation of feed can prevent pathogenic infection ( 62 ). Meanwhile, in the gut, SCFA acts as a signal molecule that regulates a versatile class of intestinal immune cells ( 63 , 64 ).…”

Section: Discussionmentioning

confidence: 99%

The effects of fucoidan as a dairy substitute on diarrhea rate and intestinal barrier function of the large intestine in weaned lambs

Guo¹,

Yang²,

Fan³

et al. 2022

Front. Vet. Sci.

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This paper explores the effects of fucoidan on the frequency of diarrhea, colon morphology, colon antioxidant status, cytokine content, short-chain fatty acids, and microflora of cecal contents in early weaned lambs in order to provide a reference for the intestinal health of young ruminants. Fucoidan is a natural active polysaccharide extracted from kelp and other large brown algae. It has many biological effects, such as improving immunity, nourishing the stomach and intestines, and anti-tumor properties. This study investigated the effects of fucoidan supplementation in milk replacer on the large intestine's ability to act as an intestinal barrier in weaned lambs. With six duplicate pens and one lamb per pen, a total of 24 weaned lambs (average starting body weight of 7.32 ± 0.37 kg) were randomly assigned to one of four milk replacer treatments. Four concentrations of fucoidan supplementation (0, 0.1, 0.3, and 0.6% dry matter intake) were employed to investigate the effects of fucoidan on cecal fermentation and colon microbial organization. The test period lasted 37 days (1 week before the test and 1 month after the test), and lamb cecal contents and colon organization were collected for examination. In addition, the fecal status of all lambs was observed and recorded daily, allowing us to calculate the incidence of diarrhea in weaned lambs. The findings demonstrated that fucoidan may significantly increase the concentration of short-chain fatty acids (propionic acid and butyric acid) in the cecal digesta of weaned lambs. In weaned lambs, 16S rDNA testing showed that fucoidan at 0.3–0.6% (dry matter intake) was beneficial for boosting the variety of the intestinal bacteria and modifying the relative abundance of a few bacterial strains. In addition, fucoidan enhanced colon antioxidant and immune functions and decreased the diarrhea rate to relieve weaning stress. This result demonstrates that milk replacer supplementation with fucoidan contributes to the improvement in the large intestinal health of weaned lambs.

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Fermentation characteristics and probiotic activity of a purified fraction of polysaccharides from Fuzhuan brick tea

Cited by 22 publications

References 62 publications

Soluble, Diferuloylated Corn Bran Glucuronoarabinoxylans Modulate the Human Gut Microbiota In Vitro

Soluble, Diferuloylated Corn Bran Glucuronoarabinoxylans Modulate the Human Gut Microbiota In Vitro

Increased abundance of Ruminococcus gnavus in gut microbiota is associated with moyamoya disease and non-moyamoya intracranial large artery disease

The effects of fucoidan as a dairy substitute on diarrhea rate and intestinal barrier function of the large intestine in weaned lambs

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