Fermentation and Mutational Development of the Tetracyclines

Goodman, Joseph J.

doi:10.1007/978-3-642-70304-1_2

Cited by 6 publications

(5 citation statements)

References 92 publications

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“…For these two types of oil, the drop size/structure at 2% (v/v) oil were investigated under conditions mimicking those in a fermentation; for instance, agitation in the presence of air bubbles, antifoam, and fine solid particles. Antifoam is frequently added to real fermentation broth to prevent extensive foaming, and solids particles are often added in antibiotic fermentations producing penicillin (Velvard et al, 1976) or tetracyclines (Goodman, 1985) to help precipitate the product. Microorganisms were not used in any of the present experiments.…”

Section: Methodsmentioning

confidence: 99%

“…On the other hand, it has also been suggested that this incorporation of air bubbles into oil drops, along with the enhanced solubility of oxygen in oil, is the reason for the reported increased oxygen transfer found in oil-based fermentations (Galindo et al, 2000). To add to this level of complexity, when such a fermentation is used for the manufacture of antibiotics, finely divided calcium carbonate is often added during the fermentation to encourage precipitation of the product via pH change (Goodman, 1985;Velvard et al, 1976).…”

Section: Fermentation Aspectsmentioning

confidence: 97%

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Oil/water and pre‐emulsified oil/water (PIT) dispersions in a stirred vessel: Implications for fermentations

Erler

Nienow²,

Pacek³

2003

Biotech & Bioengineering

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This study examines dispersions of rapeseed oil (RSO) in water by mechanical agitation under conditions mimicking those found in certain antibiotic fermentations; for example, in the presence of air, antifoam, and finely divided CaCO(3) particles. A problem with residual oil has been reported for such fermentations, and it has been suggested that the use of pre-emulsified oil can reduce this problem. Hence, the dispersion of a pre-emulsified oil produced by the "phase inversion temperature (PIT) method" has been evaluated. In both cases, the volume fraction of oil was 2%. For the RSO systems, a relatively high agitation speed was required to disperse the oil, especially in the presence of the particles and, when the agitation was stopped, separation occurred rapidly. The Sauter mean drop diameters depended on the system, being at an average energy dissipation rate of approximately 0.9 W kg(-1), 180 microm for RSO/water, 130 microm for RSO/water(antifoam)/air, 580 microm for RSO/water/CaCO(3), and 850 microm for RSO/water(antifoam)/air/CaCO(3). For the same four systems, the PIT emulsion, once dispersed, was very stable and the drop size was essentially independent of the operating conditions, with a Sauter mean diameter of approximately 0.3 microm. The implications of these findings for fermentations in which oil is used as a carbon source are assessed.

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Section: Methodsmentioning

confidence: 99%

Section: Fermentation Aspectsmentioning

confidence: 97%

Oil/water and pre‐emulsified oil/water (PIT) dispersions in a stirred vessel: Implications for fermentations

Erler

Nienow²,

Pacek³

2003

Biotech & Bioengineering

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“…The native tetracycline (TC) producing strains Streptomyces aureofaciens and S. rimosus are powerful industrial producers of chlortetracycline (CTC) and oxytetracycline (OTC), respectively, aromatic polyketide metabolites of medical and agricultural importance (Chopra and Roberts 2001 ). Industrial strains for the production of these valuable compounds have been developed over many decades by intensive mutagenesis and strain selection approaches (Goodman 1985 ). The main challenge today is to further improve the yield of target TCs, particularly by increasing the rate of conversion of the carbon source, mostly from media containing starch, while reducing the presence of undesired impurities.…”

Section: Application Case 1: Challenges Of Tetracycline Productionmentioning

confidence: 99%

Synthetic biology approaches to actinomycete strain improvement

Breitling

Avbelj

Bilyk

et al. 2021

FEMS Microbiology Letters

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Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synthetic biology approaches from an actinomycete perspective and presents examples of their application to the rational improvement of industrially relevant strains.

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“…Tetracycline activity against gram-positive and gram-negative bacteria also has the potential to work against some other pathogens while not being affected by other antibiotics. 17 Besides, Vietnam has a tropical climate with mainly 2 distinct rainy and sunny seasons in the south, so chickens were vulnerable to respiratory diseases and intestinal tract infections. For these reasons, farmers often used tetracycline or sulfonamides for the purpose of treating and preventing illnesses.…”

Section: Antibiotic Residues In Chicken Meatmentioning

confidence: 99%

Antibiotic Residues in Chickens and Farmers’ Knowledge of Their Use in Tay Ninh Province, Vietnam, in 2017

Huong-Anh¹,

Chính²,

Tuyet-Hanh

2020

Asia Pac J Public Health

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Antibiotic residues in chicken meat samples is a serious public health concern due to their harmful effects on consumers’ health. We conducted this research in 2017 to determine antibiotic residues in chicken meat samples and to describe the knowledge, attitude, and practice (KAP) of farmers on the antibiotic uses in poultry farms at Tay Ninh province. Farmers who raised chickens at their farmhouses were surveyed using a KAP survey questionnaire, and 106 chicken meat samples were analyzed for 29 kinds of antibiotic residues. The results showed that 27.4% samples were positive with 11 kinds of 4 antibiotic groups: fluoroquinolones, sulfonamides, tetracycline, and macrolides. A total of 50.9% farmers needed to improve their knowledge on the appropriate use of antibiotics. Although 54.7% famers had positive attitude, just 17% had good practices. It was recommended that the levels of antibiotic residues in chickens should be communicated to food safety and veterinary authorities, chicken farmers, and the general public. Enhancing the training and coaching for each group of farmers to improve their knowledge and practices on the appropriate use of antibiotics in raising chickens is needed. Local government should enhance the level of control and punishment for drug sellers and end users regarding the use of banned antibiotics in chickens.

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Fermentation and Mutational Development of the Tetracyclines

Cited by 6 publications

References 92 publications

Oil/water and pre‐emulsified oil/water (PIT) dispersions in a stirred vessel: Implications for fermentations

Oil/water and pre‐emulsified oil/water (PIT) dispersions in a stirred vessel: Implications for fermentations

Synthetic biology approaches to actinomycete strain improvement

Antibiotic Residues in Chickens and Farmers’ Knowledge of Their Use in Tay Ninh Province, Vietnam, in 2017

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