FericipXT-Coated PEGylated Rutile TiO2 Nanoparticles in Drug Delivery: In-vitro Assessment of Imatinib Release

Abstract

Study presents a facile synthesis strategy for magnetic field-responsive PEGylated iron-supplement-coated rutile TiO2 nanoparticles (NPs) for stimuli-responsive drug delivery. Imatinib, an anticancer drug, was successfully loaded onto the NPs, and its in-vitro release was investigated under different pH conditions. XRD analysis confirmed the successful synthesis of PEGylated iron supplement-coated rutile titania NPs. HR-TEM studies revealed increased NP size due to coating, PEGylation, and drug-loading. FTIR spectra confirmed the drug loading onto the NPs, while DLS provided hydrodynamic diameter and polydispersity index, indicating appropriate NP synthesis. The PEGylated NPs exhibited negative Zeta Potential, indicating high stability. In-vitro drug-release studies demonstrated controlled release with maximum efficiency under acidic conditions. Hemolysis assay confirmed the safety and biocompatibility of PEGylated NPs. All drug-loaded nanoformulations followed the Peppas-Sahlin model, suggesting Fickian diffusion and Case II relaxation mechanism of drug release. These NPs have potential for targeted delivery and controlled release of chemotherapeutics, minimizing side effects.