FePt nanoparticles: a novel nanoprobe for enhanced HeLa cells sensitivity to chemoradiotherapy

Bao, Zhirong; He, Mingyang; Hong, Quan; Jiang, Dean; Zheng, Yanhong; Qin, Wenjing; Zhou, Youwen; Ren, Feng; Guo, Mingxiong; Jiang, Changzhong

doi:10.1039/c6ra03990a

Cited by 20 publications

(17 citation statements)

References 50 publications

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“…To date, the development of nanomaterials has improved the diagnosis and treatment of cancers. FePt nanocomposites showed the potential applications in dual modal MRI/CT imaging 5, 6, drug delivery 7, thermal therapy 8, 9 and chemotherapy agents 32 owing to their optimal magnetic, optical properties and controllable morphology. Chen et al 33 synthesized FePt/GO nanocomposites with good activity of intrinsic peroxidase.…”

Section: Discussionmentioning

confidence: 99%

FePt/GO Nanosheets Suppress Proliferation, Enhance Radiosensitization and Induce Autophagy of Human Non-Small Cell Lung Cancer Cells

Miao

Luo

et al. 2019

Int. J. Biol. Sci.

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With the advancement of nanotechnology, various nanocomposites have been applied in the diagnostics and treatment of cancer. We synthetized FePt nanoparticles which were assembled on the surface of graphene oxide (GO). These novel FePt/GO nanosheets simultaneously act as a chemotherapy drug and enhance radiosensitivity. In this study, transmission electron microscope, dynamic light scattering, X-ray photoelectron spectroscope and Fourier transform infrared spectroscopy were used to characterize surface morphology and chemical composition of FePt/GO nanosheets (NSs). Their cytotoxicity in various cancer and normal cells was evaluated by cell counting kit-8 assay, and their effects on radiosensitization were determined by colony formation assay. To explore the underlying mechanisms, we measured the intracellular reactive oxygen species levels and autophagy formation. Monodansylcadaverine-staining, Western Blotting and ultrastructure analysis were utilized to assess autophagy. The results demonstrated that FePt/GO NSs not only selectively suppressed the proliferation of cancer cells, but also increased their radiosensitization. Moreover, FePt/GO NSs induced autophagy, which might result in promoted sensibilization of radiotherapy. In conclusion, with good safety and efficacy, FePt/GO NSs are safe and effective to suppress proliferation, enhance radiosensitization and induce autophagy of human non-small cell lung cancer cells. They are potential for the treatment of lung cancer.

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Section: Discussionmentioning

confidence: 99%

FePt/GO Nanosheets Suppress Proliferation, Enhance Radiosensitization and Induce Autophagy of Human Non-Small Cell Lung Cancer Cells

Miao

Luo

et al. 2019

Int. J. Biol. Sci.

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“…As reviewed in previous sections, most high Z metallic elements were applied for radiosensitization including X-ray contrast and computed tomography (CT) 198 . Magnetic metals, such as Gd and Fe, were utilized for MRI contrast 202 , 205 , and concurrent chemotherapy was achieved in the presence of Pt and its complexes 197 , 203 .…”

Section: Theranostic Multimetallic Nanocomposites For Future Rtmentioning

confidence: 99%

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

et al. 2018

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Radiotherapy is one of the major therapeutic strategies for cancer treatment. In the past decade, there has been growing interest in using high Z (atomic number) elements (materials) as radiosensitizers. New strategies in nanomedicine could help to improve cancer diagnosis and therapy at cellular and molecular levels. Metal-based nanoparticles usually exhibit chemical inertness in cellular and subcellular systems and may play a role in radiosensitization and synergistic cell-killing effects for radiation therapy. This review summarizes the efficacy of metal-based NanoEnhancers against cancers in both in vitro and in vivo systems for a range of ionizing radiations including gamma-rays, X-rays, and charged particles. The potential of translating preclinical studies on metal-based nanoparticles-enhanced radiation therapy into clinical practice is also discussed using examples of several metal-based NanoEnhancers (such as CYT-6091, AGuIX, and NBTXR3). Also, a few general examples of theranostic multimetallic nanocomposites are presented, and the related biological mechanisms are discussed.

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“…FePt MNPs were prepared by chemical co-reduction method as previously described [7,13,36]. Briefly, OA (1.5 ml), OL (1.5 ml) and Fe(acac) 3 (0.386 mmol) were dissolved in anhydrous ethanol (100 ml) and stirred for 30 min.…”

Section: Methodsmentioning

confidence: 99%

“…Finally, quantitative measurements (absorbance) were obtained at the wavelength of 570 nm using a multifunctional enzyme marking instrument (PE Enspire). The cell viability is calculated using the follow equation [7]:cell viability=true0A−AnormalcA0−Ac0,where A was the absorbance of experimental group, A c represents the absorbance of non-seeded group, A 0 represents the absorbance of control group, A c0 was the absorbance of RPMI-1640 medium. The results were analysed by GraphPad Prism software (Beckman Coulter, Inc.) and expressed as means ± standard deviation (s.d.…”

Section: Methodsmentioning

confidence: 99%

Development of a hypoxic nanocomposite containing high-Z element as 5-fluorouracil carrier activated self-amplified chemoradiotherapy co-enhancement

et al. 2019

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The synergetic effect of chemoradiotherapy achievement is encouraging but significantly hampered by the prevalence of hypoxia, leading to drug/radiation resistance in solid tumours. To address the problem and improve the efficiency of cancer therapy, a lamellar-structure multifunctional graphene oxide (GO) drug-delivery system with an average size of 243 nm, co-delivering of metronidazole (MI), 5-fluorouracil (5-FU) and FePt magnetic nanoparticles (MNPs), was successfully designed and synthesized in the study. The integration of hypoxic drug carrier loading radiosensitizers and chemotherapeutic drugs simultaneously, combines the properties of hypoxia-sensitivity and chemoradiotherapy co-enhancement within a single nanoplatform, which is expected to provide new ideas for cancer treatment. Through in vitro tests, the hypoxia-sensitivity and cytotoxicity of intracellular reactive oxygen species (ROS) of the nanocomposites (NCs) were proved. Moreover, the additive effect between MI, 5-FU and FePt MNPs in cytotoxicity and radiation sensitization aspects is disclosed. It performs an enhanced cell proliferation inhibition and makes up a self-amplified radiotherapy enhancement system that improves radiation efficiency and cell radiosensitivity simultaneously. In conclusion, the study recommended a novel and promising multifunctional nanoplatform which performed a self-amplified effect that activated chemoradiotherapy co-enhancement.

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FePt nanoparticles: a novel nanoprobe for enhanced HeLa cells sensitivity to chemoradiotherapy

Abstract: The present work exhibited high therapeutic efficacy of FePt nanoparticles in combination with radiotherapy without apparent cytotoxicity, suggesting the potential of FePt nanoparticles as a promising nanoprobe in improving the outcome of tumor chemoradiotherapy.

Cited by 20 publications

References 50 publications

FePt/GO Nanosheets Suppress Proliferation, Enhance Radiosensitization and Induce Autophagy of Human Non-Small Cell Lung Cancer Cells

FePt/GO Nanosheets Suppress Proliferation, Enhance Radiosensitization and Induce Autophagy of Human Non-Small Cell Lung Cancer Cells

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

Development of a hypoxic nanocomposite containing high-Z element as 5-fluorouracil carrier activated self-amplified chemoradiotherapy co-enhancement

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