Fentanyl added to bupivacaine 0.05% or ropivacaine 0.05% in patient-controlled epidural analgesia in labour

Pirbudak, Lütfiye; Tuncer, Sema; Koçoğlu, Hasan; Göksu, Sıtkı; Çelık, Çetin

doi:10.1017/s0265021502000431

Cited by 17 publications

(14 citation statements)

References 18 publications

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“…The haemodynamic parameters correlated with the previous study by Pirbudak et al, 10 and Jaime Fernandez et al, 6 were there was no statistical significance in haemodynamic parameters.…”

Section: Haemodynamic Parameterssupporting

confidence: 85%

Comparison of 0.1% Bupivacaine With 2 McG/Ml Fentanyl and 0.1% Ropivacaine With 2 McG/Ml for Labour Analgesia

B¹,

S²

2018

jebmh

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BACKGROUNDEpidural neuraxial blockade is an efficient and an easy method of administering labour analgesia without any adverse effects on the foetus. Labour analgesia thus helps the mother enjoy the delivery of her child without pain or stress enhancing patient satisfaction. Bupivacaine was the routinely used local anaesthetic for labour analgesia. Bupivacaine combined with low dose of opioid was used to reduce the concentration of bupivacaine without compromising on quality of analgesia produced and also reducing the extent of motor blockade. But even with lowering the concentration of bupivacaine used and the addition of opioids, patient had minimal motor blockade which prevented them from being ambulant. Ropivacaine has helped us to provide ambulatory analgesia by overcoming the motor blockade without compromising on the quality of analgesia.The objective of this study was to compare analgesic efficacy, onset, duration of action, total dose of anaesthetic required, intensity of motor blockade and haemodynamic stability in patients admitted for safe confinement.

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“…The haemodynamic parameters correlated with the previous study by Pirbudak et al, 10 and Jaime Fernandez et al, 6 were there was no statistical significance in haemodynamic parameters.…”

Section: Haemodynamic Parameterssupporting

confidence: 85%

Comparison of 0.1% Bupivacaine With 2 McG/Ml Fentanyl and 0.1% Ropivacaine With 2 McG/Ml for Labour Analgesia

B¹,

S²

2018

jebmh

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“…9 Later, studies maintaining labour analgesia with lower concentration of bupivacaine and ropivacaine (0.0625-0.1%) combined with fentanyl 2µg/ml suggested that dilute local anaesthetic solutions with opioids for labour PCEA results in less local anaesthetic consumption and motor block without compromising labour analgesia. 10 Ropivacaine has been recently made available in India for clinical use, there are limited reports comparing ropivacaine and bupivacaine for labour analgesia by PCEA.…”

Section: Discussionmentioning

confidence: 99%

“…Pirbudak et al 9 compared the efficacy of ropivacaine 0.05% and bupivacaine 0.05%, both combined with fentanyl 1.5µg/ml in 40 nulliparous patients to provide analgesia in labour. The results of this study where the VAS score did not increase with the progression of labour, are in line with our results.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of analgesic efficacy of the combination of fentanyl with low dose bupivacaine vs ropivacaine using patient controlled epidural analgesia for control of labour pain- an indian perspective!

Mitra¹,

Ahuja

Kulshrestha³

et al. 2015

Sri Lankan J Anaesthesiol

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Introduction:We undertook this study to compare the analgesic efficacy of 0.1% bupivacaine and 0.1% ropivacaine with fentanyl using patient controlled epidural analgesia. Materials and methods:60 parturients of ≥ 36 weeks of gestation with cephalic presentation in spontaneous labour with cervical dilatation ≤ 5cms and baseline pain score of ≥ 30 on visual analogue scale (VAS), were enrolled in the study. Group I received 10 ml bolus of 0.1% bupivacaine with fentanyl 2µg/ml while Group II received 10 ml bolus of 0.1% ropivacaine with fentanyl 2µg/ml followed by patient controlled epidural analgesia (PCEA) using PCA pump. The primary outcome measured was analgesic efficacy using VAS.Results: VAS scores during first and second hour were found to be significantly lower in Group 1 as compared to Group 2 (Figure 1) with a significant difference from their respective baselines. Group II showed a statistically higher total drug consumption and number of boluses used (62.33 ± 26.6 vs 48.47 ± 16.7 and1.40 ± 0.8 vs 2.00 ± 0.8 respectively) as compared to group I (Table 2) (Figure 3). The motor block showed a statistically significant difference at 4 th , 5 th and 6 th hours between the two groups ( Figure 4). Conclusion:The present study demonstrated that 0.1% ropivacaine or 0.1% bupivacaine with fentanyl 2µg/ml used during labour analgesia by PCEA were equally effective for controlling the labour pain with more total drug consumption and less motor blockade associated with 0.1% ropivacaine as compared to 0.1% bupivacaine.

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“…In Aşlk and colleagues' study [7], the doses compared are high by today's standards and no effects of the addition of fentanyl have been observed due to this relatively high dose used. Also in Pirbudak and colleagues [16], no significant differences were observed between the two drugs, even if they were used at a lower concentration, but fentanyl was added in a dose effective on its own and may have masked the differences in analgesia due to the local anaesthetic solutions. Further research in obstetric analgesia should be directed to investigate doses, concentration, volumes and adjuvants that may be clinically useful, and comparisons between drugs should be made at equipotent doses or concentrations.…”

mentioning

confidence: 95%

“…Another paper in this issue of the Journal by Pirbudak and colleagues [16] examines the efficacy of ropivacaine 0.05% and bupivacaine 0.05%. The drugs were both combined with fentanyl 0.00015% to provide analgesia in labour.…”

mentioning

confidence: 99%

Ropivacaine and bupivacaine in obstetric analgesia

Capogna¹

2002

EJA

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Fentanyl added to bupivacaine 0.05% or ropivacaine 0.05% in patient-controlled epidural analgesia in labour

Abstract: An epidural infusion (10 mLh(-1)) of bupivacaine 0.05% or ropivacaine 0.05% together with fentanyl 1.5 microg mL(-1) provided good and safe analgesia during labour.

Cited by 17 publications

References 18 publications

Comparison of 0.1% Bupivacaine With 2 McG/Ml Fentanyl and 0.1% Ropivacaine With 2 McG/Ml for Labour Analgesia

Comparison of 0.1% Bupivacaine With 2 McG/Ml Fentanyl and 0.1% Ropivacaine With 2 McG/Ml for Labour Analgesia

Evaluation of analgesic efficacy of the combination of fentanyl with low dose bupivacaine vs ropivacaine using patient controlled epidural analgesia for control of labour pain- an indian perspective!

Ropivacaine and bupivacaine in obstetric analgesia

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