Fenproporex and Amphetamine Pharmacokinetics in Oral Fluid After Controlled Oral Administration of Fenproporex

Comiran, Eloisa; Souza, Daniele Zago; Boehl, Paula Otero; Mariotti, Kristiane de Cássia; Pechansky, Flávio; Duarte, Paulina do Carmo Arruda Vieira; Boni, Raquel Brandini De; Fröehlich, Pedro Eduardo; Limberger, Renata Pereira

doi:10.1097/ftd.0b013e318263c6c5

Cited by 12 publications

(8 citation statements)

References 32 publications

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“…10,11 Interestingly, SG was reported as a stimulant in one article. 16 Considering the 50 mg/L initial screening cut-off concentration for AMP-type stimulants in OF, already proposed by US SAMHSA and by Standards Australia, 12,26 SG was detected in our study in 100%, 25%, and 0% of the OF specimens collected at 0.5 hours, 1 hour, and 2 hours, respectively.…”

Section: Discussionsupporting

confidence: 51%

“…OF has been successfully used as an alternative matrix for blood testing in several pharmacokinetic studies and pharmacotoxicological studies . The pharmacokinetic data is meaningful for the results interpretation in forensic analysis.…”

Section: Introductionmentioning

confidence: 99%

“…The pharmacokinetic data is meaningful for the results interpretation in forensic analysis. Besides, it can correlate with drugged drivers’ behavioral and performance studies and provide the basis to establish the detection window of the available OF screening immunoassays directed to roadside testing . However, the pharmacokinetic parameters of SG and its metabolites in OF are still unknown.…”

Section: Introductionmentioning

confidence: 99%

“…6,8,10,11 OF has been successfully used as an alternative matrix for blood testing in several pharmacokinetic studies and pharmacotoxicological studies. 12 The pharmacokinetic data is meaningful for the results interpretation in forensic analysis. Besides, it can correlate with drugged drivers' behavioral and performance studies and provide the basis to establish the detection window of the available OF screening immunoassays directed to roadside testing.…”

mentioning

confidence: 99%

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Pharmacokinetics of selegiline, R‐methamphetamine, R‐amphetamine, and desmethylselegiline in oral fluid after a single oral administration of selegiline

Chen

Shen

Wang

et al. 2019

Drug Testing and Analysis

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Background Chiral analysis is a crucial way to differentiate selegiline (SG) intake from drug abuse. Oral fluid (OF) has been successfully used as an alternative matrix for blood testing in several pharmacokinetic studies. Objective The aim of this study is to describe the pharmacokinetics of SG and its main metabolites in OF after a single oral administration of SG which is meaningful for results interpretation in forensic analysis. Methods Ten milligrams of SG were orally administered to 8 volunteers, and OF samples were collected for up to 96 hours by having participants spit into polypropylene tubes without stimulation. These samples were submitted to liquid–liquid extraction before analysis by liquid chromatography–tandem mass spectrometry operating in positive ion multiple‐reaction monitoring mode. Results and conclusions After oral administration, each analyte could be detected in OF specimens from all volunteers with an initial detection time of 0.50 hours. The Cmax values of SG, R‐MA, R‐AM and DM‐SG were 50.93–992.67 ng/mL, 29.78–653.64 ng/mL, 8.22–150.15 ng/mL, and 4.34–16.25 ng/mL, respectively, at 0.5 hours, 1–11 hours, 1.5–11 hours, and 0.5–6 hours post dose. The times when the compounds were last determined in OF were 5–24 hours for SG, 52–96 hours for R‐MA, 31–96 hours for R‐AM, and 13–31 hours for DM‐SG after oral administration. There is a period of time in OF in which only MA and AM are present without SG and DM‐SG after a single dose of SG. The pharmacokinetic data could provide supplementary interpretation for OF tests in forensic science and drug treatment programs.

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Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Pharmacokinetics of selegiline, R‐methamphetamine, R‐amphetamine, and desmethylselegiline in oral fluid after a single oral administration of selegiline

Chen

Shen

Wang

et al. 2019

Drug Testing and Analysis

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“…Desta forma, resultados falso-negativos poderiam ser encontrados, uma vez que a triagem não detectaria o uso dos moderadores de apetite utilizados em nosso país, como a anfepramona e femproporex91 . Apesar disso, já foi comprovado que após a ingestão de femproporex é possível a identificação de anfetamina em amostras de fluido oral após poucos minutos92 , o que possibilitou a utilização desses kits de ELISA na triagem das amostras. Em todas as análises toxicológicas é imprescindível a realização de uma análise confirmatória por um método com fundamento diferente daquele utilizado na triagem.…”

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Análise de anfetamina, cocaína e tetrahidrocanabinol em fluido oral de motoristas de caminhão que trafegam em rodovias do estado de São Paulo

Bombana¹

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Lisdexamfetamine and amphetamine pharmacokinetics in oral fluid, plasma, and urine after controlled oral administration of lisdexamfetamine

Comiran

Carlos

Barreto

et al. 2020

Biopharm & Drug Disp

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Lisdexamfetamine (LDX) is a long‐acting prodrug stimulant indicated for the treatment of attention‐deficit/hyperactivity disorder (ADHD) and binge‐eating disorder (BED) symptoms. In vivo hydrolysis of the LDX amide bond releases the therapeutically active d‐amphetamine (d‐AMPH). This study aims to describe the pharmacokinetics of LDX and its major metabolite d‐AMPH in human oral fluid, urine and plasma after a single 70 mg oral dose of LDX dimesylate. Six volunteers participated in the study. Oral fluid and blood samples were collected for up to 72 h and urine for up to 120 h post‐drug administration for the pharmacokinetic evaluation of intact LDX and d‐AMPH. Samples were analyzed by LC‐MS/MS. Regarding noncompartmental analysis, d‐AMPH reached the maximum concentration at 3.8 and 4 h post‐administration in plasma and oral fluid, respectively, with a mean peak concentration value almost six‐fold higher in oral fluid. LDX reached maximum concentration at 1.2 and 1.8 h post‐administration in plasma and oral fluid, respectively, with a mean peak concentration value almost three‐fold higher in plasma. Intact LDX and d‐AMPH were detected in the three matrices. The best fit of compartmental analysis was found in the one‐compartment model for both analytes in plasma and oral fluid. There was a correlation between oral fluid and plasma d‐AMPH concentrations and between parent to metabolite concentration ratios over time in plasma as well as in oral fluid.

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Fenproporex and Amphetamine Pharmacokinetics in Oral Fluid After Controlled Oral Administration of Fenproporex

Cited by 12 publications

References 32 publications

Pharmacokinetics of selegiline, R‐methamphetamine, R‐amphetamine, and desmethylselegiline in oral fluid after a single oral administration of selegiline

Pharmacokinetics of selegiline, R‐methamphetamine, R‐amphetamine, and desmethylselegiline in oral fluid after a single oral administration of selegiline

Análise de anfetamina, cocaína e tetrahidrocanabinol em fluido oral de motoristas de caminhão que trafegam em rodovias do estado de São Paulo

Lisdexamfetamine and amphetamine pharmacokinetics in oral fluid, plasma, and urine after controlled oral administration of lisdexamfetamine

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