Fenpropathrin exposure induces neurotoxicity in zebrafish embryos

Yu, Tingting; Xu, Xiaowen; Mao, Huiling; Han, Xue; Liu, Yulong; Zhang, Hongying; Lai, Jingli; Gu, Jianfeng; Xia, Mengling; Hu, Chengyu; Li, Dongming

doi:10.1007/s10695-022-01134-9

Cited by 16 publications

(7 citation statements)

References 44 publications

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“…These genes encompass immature neuronal markers like nestin ( Chen et al, 2012 ; Ho et al, 2013 ; Soares et al, 2017 ; Qian et al, 2018 ; Cheng et al, 2020 ; Xia et al, 2021 ; Xu et al, 2022a ; Xu et al, 2022b ; Yu et al, 2022 ; Xu et al, 2023 ), as well as mature neuronal markers like growth associated protein 43 ( gap43 ) ( Chen et al, 2012 ; Sun et al, 2016 ; Soares et al, 2017 ; Faria et al, 2018 ; Qian et al, 2018 ; Shi et al, 2018 ; Jin et al, 2019b ; Li et al, 2019 ; Cheng et al, 2020 ; Zhu et al, 2020 ; Chen et al, 2021 ; Gyimah et al, 2021 ; Li et al, 2021 ; Tian et al, 2021 ; Xu et al, 2021 ; Xu et al, 2022a ; Xu et al, 2022b ; Yu et al, 2022 ; Shi et al, 2023 ; Xiong et al, 2023 ; Xu et al, 2023 ; Zhu et al, 2023 ), and elav like RNA binding protein 3 ( elavl3 ) ( Chen et al, 2012 ; Sun et al, 2016 ; Qian et al, 2018 ; Shi et al, 2018 ; Yang et al, 2019 ; Zhu et al, 2020 ; Chen et al, 2021 ; Gyimah et al, 2021 ; Wang et al, 2021 ; Xu et al, 2021 ; Xu et al, 2022a ; Xu et al, 2022b ; Fan et al, 2022 ; Wang et al, 2022 ; Yu et al, 2022 ; Xiong et al, 2023 ; Zhu et al, 2023 ). Additionally, astrocyte markers such as glial fibrillary acidic protein ( gfap ) ( Chen et al, 2012 ; Sun et al, 2016 ; Soares et al, 2017 ; Faria et al, 2018 ; Li et al, 2018 ; Qian et al, 2018 ; Shi et al, 2018 …”

Section: Neurotoxic Effect On Embryonic Developmentmentioning

confidence: 99%

“…Gene expression analysis related to axons has demonstrated alteration in the expression of regeneration-associated genes such as growth-associated protein Gap-43 ( gap43 ) ( Chen et al, 2012 ; Sun et al, 2016 ; Soares et al, 2017 ; Faria et al, 2018 ; Qian et al, 2018 ; Shi et al, 2018 ; Jin et al, 2019b ; Li et al, 2019 ; Cheng et al, 2020 ; Zhu et al, 2020 ; Chen et al, 2021 ; Gyimah et al, 2021 ; Li et al, 2021 ; Tian et al, 2021 ; Xu et al, 2021 ; Xu et al, 2022a ; Xu et al, 2022b ; Chang et al, 2022 ; Yu et al, 2022 ; Shi et al, 2023 ; Xiong et al, 2023 ; Xu et al, 2023 ; Zhu et al, 2023 ) and α1 tubulin ( Sun et al, 2016 ; Li et al, 2018 ; Shi et al, 2018 ; Yang et al, 2019 ; Fu et al, 2020 ; Zhu et al, 2020 ; Chen et al, 2021 ; Gyimah et al, 2021 ; Xu et al, 2021 ; Xu et al, 2022a ; Xu et al, 2022b ; Heredia-García et al, 2023 ; Shi et al, 2023 ; Xu et al, 2023 ). Additionally, nerve related genes like pax6a ( Ho et al, 2013 ; Li et al, 2019 ; Wang et al, 2021 ; Gyimah et al, 2022 ), elavl3 ( Chen et al, 2012 ; Sun et al, 2016 ; Qian et al, 2018 ; Shi et al, 2018 ; Yang et al, 2019 ; Zhu et al, 2020 ; Chen et al, 2021 ; Gyimah et al, 2021 ; Wang et al, 2021 ; Xu et al, 2021 ; Xu et al, 2022a ; Xu et al, 2022b ; Fan et al, 2022 ; Wang et al, 2022 ; Yu et al, 2022 ;…”

Section: Morphology and Characteristics Of Neuronsmentioning

confidence: 99%

“…At the synaptic level, neurotoxicity can disrupt the expression of synaptic vesicle cycling genes such as synapsin 2a ( syn2a ) ( Chen et al, 2012 ; Sun et al, 2016 ; He et al, 2017 ; Faria et al, 2018 ; Li et al, 2018 ; Qian et al, 2018 ; Shi et al, 2018 ; Jin et al, 2019b ; Li et al, 2019 ; Zhu et al, 2020 ; Gu et al, 2021 ; Tian et al, 2021 ; Xu et al, 2022a ; Xu et al, 2022b ; Gyimah et al, 2022 ; Haridevamuthu et al, 2022 ; Wang et al, 2022 ; Yu et al, 2022 ; Shi et al, 2023 ; Xiong et al, 2023 ), syntaxin binding protein 1b ( stxbp1b ), synaptotagmin 1a ( syt1a ) ( Faria et al, 2018 ; Haridevamuthu et al, 2022 ), and nsfa (N-ethylmaleimide-sensitive factor a) ( Faria et al, 2018 ) ( Supplementary Table S2 ). For instance, reduced syn2a expression has been observed following treatment with olaquindox ( Guo et al, 2021 ), methamidophos ( He et al, 2017 ), lead ( Li et al, 2019 ), and TDCPP ( Wang et al, 2015 ).…”

Section: Morphology and Characteristics Of Neuronsmentioning

confidence: 99%

“…For instance, exposure to fluoxetine or a combination of microcystin-LR and nitrite significantly decreased AchE expression and activity in zebrafish brain ( Yang et al, 2022 ; Orozco-Hernandez et al, 2022 ). Additionally, exposure to waterborne microplastics led to increased AchE and ChAT activity in the zebrafish brain ( Yu et al, 2022 ).…”

Section: Neurotransmissionmentioning

confidence: 99%

“…The neurotoxic effects on the GABAergic system are typically investigated in zebrafish by analysing the expression of genes associated with the GABAergic pathway, such as GABA synthesizers [ gad1b ( Cheng et al, 2020 ; Shi et al, 2022 ; Yu et al, 2022 ; Ding et al, 2023 ; Xiang et al, 2023 ) and gad2 ( Ding et al, 2023 )], receptors ( gabra1 ( Shi et al, 2022 ; Liu et al, 2023 ; Ding et al, 2023 ), gabra6a ( Atzei et al, 2021 ), gabra6b ( Liu et al, 2023 ), gabrb3 ( Luo et al, 2023 ), gabrg2 ( Ding et al, 2023 ; Xiang et al, 2023 )), and transporters ( gat1 ( Cheng et al, 2020 ; Ding et al, 2023 ; Xiang et al, 2023 ), gat3 , vgat ). For example, exposure to lead has been shown to increase gad1b and gad2 expression and modulate the expression of gabra1 , gabbr1a , gat1 , gat3 , vgat expression ( Wirbisky et al, 2014 ) ( Supplementary Table S2 ).…”

Section: Neurotransmissionmentioning

confidence: 99%

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Temperature- and chemical-induced neurotoxicity in zebrafish

Toni,

Arena,

Cioni

et al. 2023

Front. Physiol.

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Throughout their lives, humans encounter a plethora of substances capable of inducing neurotoxic effects, including drugs, heavy metals and pesticides. Neurotoxicity manifests when exposure to these chemicals disrupts the normal functioning of the nervous system, and some neurotoxic agents have been linked to neurodegenerative pathologies such as Parkinson’s and Alzheimer’s disease. The growing concern surrounding the neurotoxic impacts of both naturally occurring and man-made toxic substances necessitates the identification of animal models for rapid testing across a wide spectrum of substances and concentrations, and the utilization of tools capable of detecting nervous system alterations spanning from the molecular level up to the behavioural one. Zebrafish (Danio rerio) is gaining prominence in the field of neuroscience due to its versatility. The possibility of analysing all developmental stages (embryo, larva and adult), applying the most common “omics” approaches (transcriptomics, proteomics, lipidomics, etc.) and conducting a wide range of behavioural tests makes zebrafish an excellent model for neurotoxicity studies. This review delves into the main experimental approaches adopted and the main markers analysed in neurotoxicity studies in zebrafish, showing that neurotoxic phenomena can be triggered not only by exposure to chemical substances but also by fluctuations in temperature. The findings presented here serve as a valuable resource for the study of neurotoxicity in zebrafish and define new scenarios in ecotoxicology suggesting that alterations in temperature can synergistically compound the neurotoxic effects of chemical substances, intensifying their detrimental impact on fish populations.

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