Fenómeno de acomodación inmunológica: Trasplante hepático ABO incompatible. Caso clínico

Abstract

We report a 33 year-old female with a diagnosis of halothaneinduce fulminant hepatic failure who was subjected to a liver transplant with an ABOincompatible graft. The patient received a therapeutic protocol that included total plasma exchange, splenectomy and quadruple immunosuppression. After 5 years, the patient remains asymptomatic and with normal liver enzymes, while she has been treated with low dose of immunosuppressive drugs. This case demonstrates an example of how the immunological process of accomodation opens the possibility of using ABO-incompatible organs as a definitive grafts (Rev Méd Chile 2009; 137: 1061-5). (