Fenoldopam — A Selective Peripheral Dopamine-Receptor Agonist for the Treatment of Severe Hypertension

Murphy, Michael B.; Murray, Clare; Shorten, George

doi:10.1056/nejmra010253

Cited by 218 publications

(108 citation statements)

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“…996 Fenoldopam, a selective dopamine D 1 receptor agonist that causes vasodilatation and increases renal cortical and outer medullary blood flow, seems to exert protective renal effects in critically ill patients. 994,995 A meta-analysis of the data from 1059 patients reported in 13 randomized and case-matched studies showed that fenoldopam exerts a beneficial effect on renal function. Compared with standard therapy, fenoldopam reduced the need for renal replacement therapy (5.7% versus 13.4%; OR: 0.37; 95% CI: 0.23 to 0.59; PϽ0.001) and lowered the peak value for serum creatinine concentration.…”

Section: Classmentioning

confidence: 99%

2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery

et al. 2011

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Section: Classmentioning

confidence: 99%

2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery

et al. 2011

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“…1 Stimulation of DRD1 by fenoldopam, a D1-like agonist, decreases blood pressure, 14 whereas inhibition of DRD1 by ecopipam, a long-acting DRD1 antagonist, has the opposite effect. 15 Furthermore, DRD1 knock-out mice have an elevated blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Blood Pressure and Renal Sodium Handling in Relation to Genetic Variation in the DRD1 Promoter and GRK4

et al. 2008

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Abstract-Activation of type-1 dopamine receptors (DRD1) reduces renal sodium reabsorption. In a family-based random sample of 611 untreated whites (women, 45.0%; mean age, 38.6 years), we measured blood pressure (BP). We used the endogenous lithium clearance to assess fractional sodium excretion (FE Na ) and proximal (RNa prox ) and distal (RNa dist ) tubular sodium reabsorption. We investigated multivariate-adjusted associations with the DRD1 promoter (AϪ48G, GϪ94A, and CϪ800T) and GRK4 (Ala142Val Key Words: blood pressure Ⅲ clinical genetics Ⅲ dopamine receptor gene Ⅲ GRK4 Ⅲ lithium clearance Ⅲ population science Ⅲ tubular transport D opamine reduces sodium reabsorption in the proximal renal tubules via activation of dopamine type-1 (DRD1) receptors, which leads to inhibition of sodium transporters, including the Na,H-exchanger and Na,K-ATPase. 1 The DRD1 promoter harbors several single-nucleotide polymorphisms (SNPs), 2 which influence the expression of the gene. Dopamine exerts its actions via G protein-coupled receptors, which in turn are under control of G protein-coupled receptor kinases (GRKs). 1 Amino-acid changing polymorphisms in one particular member of this family, GRK4, cause hyperphosphorylation, desensitization, and internalization of the DRD1 receptor and enhance the expression of the angiotensin II type-1 receptor. 1 The genes encoding DRD1 and GRK4 localize to chromosomes 5q35.1 3 and 4p16.3, 4 respectively. The GRK4 gene locus is embedded in a cluster on chromosome 4p16, which is associated with hypertension 5,6 and also includes ␣-adducin (ADD1). To our knowledge, there are no studies showing significant genome-wide linkage of hypertension with the DRD1 locus, although a genome-scan meta-analysis 7 identified 5q as a suggestive region.Measuring the clearance of endogenous lithium provides a way of estimating sodium handling in the proximal and postproximal nephron. 8,9 Expressing the renal clearance of endogenous lithium as a fraction of creatinine clearance provides a measure of tubular sodium reabsorption that is standardized for the glomerular filtration rate. 8,9 The fractional excretion of lithium (FE Li ) is a noninvasive marker of proximal tubular sodium handling and the proportion of sodium escaping reabsorption in the proximal segment of the nephron. FE Li also allows the calculation of the fractional distal reabsorption of sodium (RNa dist ). To our knowledge, no prior study addressed the possible association of these renal

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“…It is successfully used in treatment of shock as it dilates renal arteries through activation of dopamine-1 (DA1) receptors and enhances cardiac activity via activation of cardiac -adrenergic receptors [20,27]. Dopamine receptors on vascular smooth muscles are classified by [30,31] as DA1.…”

Section: Dopaminementioning

confidence: 99%

Structure and Function of Smooth Muscle with Special Reference to Mast Cells

Vodenicharov¹

2012

Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues - From Molecules to Humans

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Fenoldopam — A Selective Peripheral Dopamine-Receptor Agonist for the Treatment of Severe Hypertension

Cited by 218 publications

References 74 publications

2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery

2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery

Blood Pressure and Renal Sodium Handling in Relation to Genetic Variation in the DRD1 Promoter and GRK4

Structure and Function of Smooth Muscle with Special Reference to Mast Cells

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