Fenoldopam: A New Dopamine Agonist for the Treatment of Hypertensive Urgencies and Emergencies

Post, James; Frishman, William H.

doi:10.1002/j.1552-4604.1998.tb04369.x

Cited by 53 publications

(10 citation statements)

References 55 publications

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“…Fenoldopam is a dopamine D1-like receptor agonist clinically used as a vasodilator in cases of extreme hypertension (Murphy et al, 2001; Post and Frishman, 1998). Lithium has a much less defined function and is clinically used to treat a wide range of mental disorders, including bipolar disorder (Marmol, 2008).…”

Section: Discussionmentioning

confidence: 99%

Lengthening primary cilia enhances cellular mechanosensitivity

Spasic¹,

Jacobs

2017

eCM

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The primary cilium is a mechanosensor in a variety of mammalian cell types, initiating and directing intracellular signaling cascades in response to external stimuli. When primary cilia formation is disrupted, cells have diminished mechanosensitivity and an abrogated response to mechanical stimulation. Due to this important role, we hypothesized that increasing primary cilia length would enhance the downstream response, and therefore, mechanosensitivity. To test this hypothesis, we increased osteocyte primary cilia length with fenoldopam and lithium and found that cells with longer primary cilia are more mechanosensitive. Furthermore, fenoldopam treatment potentiated adenylyl cyclase activity and was able to recover primary cilia form and sensitivity in cells with impaired cilia. This work demonstrates that modulating the structure of the primary cilium directly impacts cellular mechanosensitivity. Our results implicate cilium length as a potential therapeutic target for combating numerous conditions characterized by impaired cilia function.

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Section: Discussionmentioning

confidence: 99%

Lengthening primary cilia enhances cellular mechanosensitivity

Spasic¹,

Jacobs

2017

eCM

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“…Accordingly, in the absence of detailed management guidelines and algorithms supported by data from the appropriate clinical trials, practitioners employ a number of diverse protocols, with quite varied results. [22][23][24][25][26][27][28][29][30][31][32][33] …”

Section: Introductionmentioning

confidence: 99%

Clinical presentation and management of patients with uncontrolled, severe hypertension: results from a public teaching hospital

et al. 1999

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ContextPatients: Ninety-one of 2898 consecutive visits to a public teaching hospital emergency department were specifically for severe, uncomplicated hypertension. Results: Of 2898 consecutive medical emergency department visits, there were 142 (4.9%) patient visits specifically for systolic blood pressure (SBP) у220 mm Hg or diastolic blood pressure (DBP) у120 mm Hg. Ninety-one of the 142 patient visits were for severe hypertension in the absence of acute target organ impact or neuroretinopathy. Eighty-nine patients received acute drug therapy. Twenty-nine patients received two drugs, and 15 received three drugs. Sixty-

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“…Drugs targeting dopamine receptors have been used to treat various pathological conditions including Parkinson's disease, schizophrenia, and hypertension. Dopamine receptor antagonists, such as flupentixol and (+)butaclamol, have been utilized as antipsychotic drugs (Tiberi and Caron, 1994), whereas dopamine receptor agonists, such as fenoldopam, are used as antihypertension drugs (Post and Frishman, 1998). However, the occurrence of severe side effects of these drugs is a major downfall of these treatments, and many efforts have been made to reduce the side effects by modifying the structures of the molecules and by increasing their receptor specificities.…”

Section: Introductionmentioning

confidence: 98%