Fenofibrate photoallergy – relevance of patch and photopatch testing

Rato, Margarida; Gil, Francisco; Monteiro, Ana Filipe; Parente, Joana

doi:10.1111/cod.12953

Cited by 20 publications

(4 citation statements)

References 6 publications

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“…During our testing cinnamyl alcohol gave, however, significantly more positive reactions than cinnamal in those with photocontact allergy to ketoprofen. Similar test results came from other research groups as well 2,4,11,31,56,57 . As errors in labelling of test preparations, as well as impurities, have been reported by scientists in the past, 18‐20 we decided to ensure that our patients were tested with correct substances.…”

Section: Discussionsupporting

confidence: 58%

“…Similar test results came from other research groups as well. 2,4,11,31,56,57 As errors in labelling of test preparations, as well as impurities, have been reported by scientists in the past, [18][19][20] we decided to ensure that our patients were tested with correct substances. We performed chemical analyses of the patch test preparations of cinnamal and cinnamyl alcohol that verified that the labelled substances were present in the test preparations.…”

Section: Discussionmentioning

confidence: 99%

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Contact allergy to fragrance mix I and its components in individuals with photocontact allergy to ketoprofen

et al. 2021

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Background: Contact allergy to fragrance mix I (FM I) is over-represented in patients photoallergic to ketoprofen. The prevalence of contact allergy to two components of FM I, cinnamal and cinnamyl alcohol, in ketoprofen-photoallergic patients is higher than in dermatitis patients.Objective: To explore the prevalence of contact allergy to FM I and its individual components in patients with photocontact allergy to ketoprofen, and to compare with a dermatitis and the general population.Methods: Data on patch and photopatch tests performed between 2009-2018 were collected. Ketoprofen-photoallergic patients were compared with dermatitis patients and published data on the general population regarding the prevalence and the distribution of contact allergy to FM I and its components.Results: A higher prevalence of contact allergy to cinnamyl alcohol compared with cinnamal (23.3% vs 10.0%), and eugenol compared with isoeugenol (23.3% vs 6.7%), was observed in ketoprofen-photoallergic patients, while the relationship was the opposite in the dermatitis group (0.7% vs 1.05%; 0.4% vs 0.9%). The overall prevalence of contact allergy to several components of FM I was significantly higher in ketoprofen-photoallergic patients.Conclusions: Contact allergy to FM I and many of its components is over-represented in patients photoallergic to ketoprofen compared with dermatitis patients and the general population.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Contact allergy to fragrance mix I and its components in individuals with photocontact allergy to ketoprofen

et al. 2021

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“…Retinoids, namely isotretinoin increases UV sensitivity, and very occasionally photosensitivity has been described with antidiabetics (glibenclamide and sitagliptin), the anticonvulsant carbamazepine 4 , flutamide 118 , and finasteride 50 and even with amoxicillin 119 . Therefore, all suspected drugs have to be considered and photopatch or photoprovocation tests should be performed to establish a correct diagnosis.…”

Section: Cardiovascular Drugsmentioning

confidence: 99%

Drug-induced photosensitivity

Gouveia

Gameiro

Coutinho

et al. 2023

PJDV

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Drug photosensitivity is a relatively frequent adverse event, although not always recognized due to its clinical polymorphism and difficulties in performing tests to prove drug causality.The aim of this report is to review the mechanisms of photosensitivity related with topical and systemic drugs (phototoxicity, photoallergy, autoimmunity, and enhanced photocarcinogenesis), the main acute and delayed clinical manifestations (acute sunburn or eczema, pseudoporphyria, photo-onycholysis, dyschromia, telangiectasia, subacute lupus erythematosus, pre-cancerous lesions, and cutaneous neoplasia), the main culprits [non-steroidal anti-inflammatory drugs (NSAIDs), antimicrobials, like fluoroquinolones and tetracyclines, psychotropic, anticancer, and cardiovascular drugs] and the most adequate diagnostic procedures (photopatch and drug photoprovocation tests).

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“…Other NSAIDs analogous to ketoprofendexketoprofen, piketoprofen, and ibuprofen -and diclofenac, now frequently used in the treatment of actinic keratosis with cases reported of PhACD [105,106], as well as chlorpromazine, responsible for recent cases of PhACD in caregivers [17,18], were proposed to be included in the extended series. Fenofibrate was also included, as positive photopatch tests confirm the diagnosis of systemic fenofibrate photosensitivity [33,107], but they also occur in the context of photoallergy to ketoprofen due a common benzophenone structure in these chemicals [108,49]. "Historical" photoallergens, like olaquindox a swine feed additive banned by the European Commission in 1998, and some halogenated salicylanilides, removed from disinfectants and hygiene products in most countries since 1976, which caused PhACD from "imported" products, are also recommended to include in an extended photopatch test tray [3] (Table 5).…”

Section: Topical and Systemic Drugsmentioning

confidence: 99%

Photopatch Testing

Gonçalo¹

2019

Contact Dermatitis

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Photopatch testing is a procedure that combines patch testing with UV irradiation. It is primarily indicated to study photoallergic contact dermatitis, but it can also contribute to establish a correct diagnosis of any exposed site dermatitis or systemic drug photosensitivity. Photopatch testing has been standardized with the input of the European Society of Contact Dermatitis and European Society of Photodermatology, but it is still seldom performed. It consists on the application of two sets of allergens for 1 or 2 days, irradiation of one set at D1 or D2 with 5 J/cm 2 of UVA, and readings immediately after irradiation and two or more days thereafter. A European photopatch test

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Fenofibrate photoallergy – relevance of patch and photopatch testing

Cited by 20 publications

References 6 publications

Contact allergy to fragrance mix I and its components in individuals with photocontact allergy to ketoprofen

Contact allergy to fragrance mix I and its components in individuals with photocontact allergy to ketoprofen

Drug-induced photosensitivity

Photopatch Testing

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