Fenofibrate and fenofibric acid analysis by capillary electrophoresis

Shihabi, Zak K.

doi:10.1002/elps.200305849

Cited by 11 publications

(8 citation statements)

References 15 publications

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“…An increase in the SDS concentration from 10, 20 to 30 mg/mL increased the peak height of iohexol slightly. It also increased slightly the retention time as expected [21].…”

Section: Resultssupporting

confidence: 56%

Serum iohexol analysis by micellar electrokinetic capillary chromatography

Shihabi

Hinsdale

2006

Electrophoresis

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A simple and rapid ( approximately 4 min) method for the measurement of iohexol in serum for assessing the glomerular filtration rate is described. It is based on direct serum injection on the capillary by MEKC. The method is linear between 8 and 260 mg/L, with an RSD of peak height of 2.9%. Several simple steps have contributed to an improved daily precision, such as choosing a high pH buffer, increasing the SDS concentration, frequent standardization, and eliminating any sample pretreatment.

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“…An increase in the SDS concentration from 10, 20 to 30 mg/mL increased the peak height of iohexol slightly. It also increased slightly the retention time as expected [21].…”

Section: Resultssupporting

confidence: 56%

Serum iohexol analysis by micellar electrokinetic capillary chromatography

Shihabi

Hinsdale

2006

Electrophoresis

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“…Thus, it is important to explore simple methods that can improve the resolution and sensitivity is not affected by high levels of salts. The addition of ACN to the sample would eliminate the effect of proteins and enable tolerating a high concentration of salts with good stacking [38][39][40]. Hence, the concentration of ACN in the HS was optimized (see Figs.…”

Section: Effect Of Acn and Nacl In Sample Matrixmentioning

confidence: 99%

“…Shihabi introduced 66% ACN into a high salt sample solution (HS) in order to reduce its conductivity and thus perform FASI effectively [38][39]. In addition, ACN was also proved to be favorable for precipitation of proteins in real samples [38][39][40].…”

Section: Introductionmentioning

confidence: 98%

Separation and detection of isoquinoline alkaloids using MEEKC coupled with field‐amplified sample injection induced by ACN

Huang

et al. 2009

Electrophoresis

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New methods based on MEEKC coupling with field-amplified sample injection (FASI) induced by ACN were proposed for five isoquinoline alkaloids (berberine, palmatine, jatrorrhizine, sinomenine and homoharringtonine) in no salt and high salt sample solution (HS). For the separation of five isoquinoline alkaloids, a running buffer composed of 18 mM sodium cholate, 2.4% v/v butan-1-ol, 0.6% v/v ethyl acetate, 10% v/v (or 30% v/v) methanol and 87.0% v/v (or 67% v/v) 5 mM Na2B4O7~10 mM NaH2PO4 buffer (pH 7.5) was developed. In order to improve the sensitivity, FASI induced by ACN was applied to increase the detection sensitivity. The detection limit was found to be as low as 0.0002 microg/mL in no salt sample solution and 0.062 microg/mL in HS. The method has been applied for the analysis of human urine spiked with analytes, and the assay results were proved to be satisfactory, and also the determination of berberine in urine sample after oral administration berberine.

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“…In addition to the aforementioned works, both CE alone and CE-MS have been used to analyze primaquine and carboxyprimaquine [145], leukotrienes, prostaglandins, thromboxane B 2 , and their metabolites [146]. They have also been used to analyze the metabolites of amitriptyline produced by Caenorhabditis elegans [147], antimicrobial metabolites monoacetylphloroglucinol and 2,4-diacetylphloroglucinol [148], and fenofibrate and fenofibric acid [149], and for the determination of bupivacaine and metabolites in rat urine [150], the simultaneous detection of S-adenosylmethionine and S-adenosylhomocysteine in mouse and rat tissues [151], the determination of residues of enrofloxacin and its metabolite ciprofloxacin in chicken muscle [152], the separation and detection of angiotensin peptides [153], the determination of viagra and its metabolite (UK-103,320) in human serum [154].…”

Section: Ce In Metabolomicsmentioning

confidence: 99%

Capillary electrophoresis at the omics level: Towards systems biology

et al. 2006

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Emerging systems biology aims at integrating the enormous amount of existing omics data in order to better understand their functional relationships at a whole systems level. These huge datasets can be obtained through advances in high-throughput, sensitive, precise, and accurate analytical instrumentation and technological innovation. Separation sciences play an important role in revealing biological processes at various omic levels. From the perspective of systems biology, CE is a strong candidate for high-throughput, sensitive data generation which is capable of tackling the challenges in acquiring qualitative and quantitative knowledge through a system-level study. This review focuses on the applicability of CE to systems-based analytical data at the genomic, transcriptomic, proteomic, and metabolomic levels.

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Fenofibrate and fenofibric acid analysis by capillary electrophoresis

Cited by 11 publications

References 15 publications

Serum iohexol analysis by micellar electrokinetic capillary chromatography

Serum iohexol analysis by micellar electrokinetic capillary chromatography

Separation and detection of isoquinoline alkaloids using MEEKC coupled with field‐amplified sample injection induced by ACN

Capillary electrophoresis at the omics level: Towards systems biology

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