Fengbaisan suppresses endoplasmic reticulum stress by up-regulating SIRT1 expression to protect rats with chronic obstructive pulmonary diseases

Wang, Yu; Su, Nan-xiang; Pan, San-Gai; Ge, Xiaoping; Dai, Xing-Ping

doi:10.1080/13880209.2020.1806335

Cited by 9 publications

(10 citation statements)

References 22 publications

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“…It has been reported that more than 3 million people die of COPD worldwide, accounting for 6% of all deaths ( 55 ). Moreover, COPD can further develop into pulmonary heart disease and respiratory failure ( 117 ), so it is of great significance to find a better treatment strategy for COPD. Zhou et al ( 118 ) reported that oxidative stress, inflammation, and apoptosis were considered the most important influential factors for COPD occurrence.…”

Section: Multitasking Roles In Respiratory Diseasesmentioning

confidence: 99%

As a Modulator, Multitasking Roles of SIRT1 in Respiratory Diseases

2022

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As far the current severe coronavirus disease 2019 (COVID-19), respiratory disease is still the biggest threat to human health. In addition, infectious respiratory diseases are particularly prominent. In addition to killing and clearing the infection pathogen directly, regulating the immune responses against the pathogens is also an important therapeutic modality. Sirtuins belong to NAD+-dependent class III histone deacetylases. Among 7 types of sirtuins, silent information regulator type-1 (SIRT1) played a multitasking role in modulating a wide range of physiological processes, including oxidative stress, inflammation, cell apoptosis, autophagy, antibacterial and antiviral functions. It showed a critical effect in regulating immune responses by deacetylation modification, especially through high-mobility group box 1 (HMGB1), a core molecule regulating the immune system. SIRT1 was associated with many respiratory diseases, including COVID-19 infection, bacterial pneumonia, tuberculosis, and so on. Here, we reviewed the latest research progress regarding the effects of SIRT1 on immune system in respiratory diseases. First, the structure and catalytic characteristics of SIRT1 were introduced. Next, the roles of SIRT1, and the mechanisms underlying the immune regulatory effect through HMGB1, as well as the specific activators/inhibitors of SIRT1, were elaborated. Finally, the multitasking roles of SIRT1 in several respiratory diseases were discussed separately. Taken together, this review implied that SIRT1 could serve as a promising specific therapeutic target for the treatment of respiratory diseases.

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Section: Multitasking Roles In Respiratory Diseasesmentioning

confidence: 99%

As a Modulator, Multitasking Roles of SIRT1 in Respiratory Diseases

2022

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“…Dioscorea oppositifolia L. DIOSCOREACEAE India, Sri Lanka, Bangladesh, Birmania Shan yao, batata china Rizomas secos fragmentados envasados Asma, tos, disnea, bronquitis crónica, enfermedad pulmonar obstructiva crónica. Antiinflamatorio, protector pulmonar, inmunomodulador (Wang et al, 2020b). Antitusivo, antiséptico del tracto respiratorio superior (Barth et al, 2015;Hurrell y Puentes, 2017).…”

Section: Asteraceae China Ju Hua Crisantemo Inflorescencias Secas Fra...unclassified

“…Ophiopogon japonicus (Thunb. ) Antitusivo, antiinflamatorio, inmunomodulador, protector pulmonar, antimicrobiano (Chen et al, 2016;Yao et al, 2019;Wang et al, 2020b).…”

Section: Nelumbo Nuciferaunclassified

Plants used to treat respiratory diseases introduced by Bolivian and Chinese immigrants in the Metropolitan Area of Buenos Aires, Argentina

Puentes¹,

Arenas²,

Hurrell³

2022

BLACPMA

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This contribution includes the registry of 28 species of medicinal plants and their derived products used to treat respiratory diseases in theMetropolitan Area of Buenos Aires, Argentina, introduced by Bolivian and Chinese immigrants. Information on these species (their assigned local uses) was obtained from interviews with local informants and from other sources, such as labels, brochures and catalogs, print and electronic. A bibliographic review was carried out on the biological activity and effects studied in order to evaluate its correspondence with the assigned local uses. The degree of visibility of the treated species was analyzed, according to their circulation in the restricted commercial circuits (Chinese and Bolivian immigrants) and the general commercial circuit. Of the total, 17 species belong to the segment of Chinese immigrants, and the remaining 11 to the Bolivian segment. The most frequently reported respiratory conditions are: "asthma", "cough", "bronchitis", "respiratory tract infections", "lung ailments". The immigrant segments play a fundamental role in the conservation of biocultural diversity in the study area.

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“…UPR activation was also detected in animal models of CS-induced COPD. Increased protein and mRNA expression levels of CHOP and GRP78 were detected in the lung tissues of COPD rats [ 117 , 118 ]. Long-term exposure to CS also increased the expression levels of the GRP78, ATF4, ATF6, and CHOP proteins and the phosphorylation of PERK and IRE1 in the lung tissues of mice [ 12 ].…”

Section: Copd and Er Stressmentioning

confidence: 99%

“…As previously described, all three UPR branches cause inflammatory responses. Significant ER stress was observed in the lung tissues of CS-induced COPD animal models, with elevations in the total inflammatory cell levels and neutrophil percentages in the bronchoalveolar lavage fluid and significantly increased levels of the inflammatory factors IL-6, IL-8, and TNF-α [ 12 , 118 ]. CS stimulation also activates the NLRP3 inflammasome, which promotes the secretion of IL-1β and IL-18 in the lung tissue [ 129 ].…”

Section: Copd and Er Stressmentioning

confidence: 99%

Endoplasmic Reticulum Stress in Chronic Obstructive Pulmonary Disease: Mechanisms and Future Perspectives

Yang

et al. 2022

Biomolecules

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The endoplasmic reticulum (ER) is an integral organelle for maintaining protein homeostasis. Multiple factors can disrupt protein folding in the lumen of the ER, triggering ER stress and activating the unfolded protein response (UPR), which interrelates with various damage mechanisms, such as inflammation, apoptosis, and autophagy. Numerous studies have linked ER stress and UPR to the progression of chronic obstructive pulmonary disease (COPD). This review focuses on the mechanisms of other cellular processes triggered by UPR and summarizes drug intervention strategies targeting the UPR pathway in COPD to explore new therapeutic approaches and preventive measures for COPD.

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Fengbaisan suppresses endoplasmic reticulum stress by up-regulating SIRT1 expression to protect rats with chronic obstructive pulmonary diseases

Abstract: , San-gai Pan , Xiao-ping Ge & Xing-ping Dai To cite this article: Yu Wang , Nan-xiang Su , San-gai Pan , Xiao-ping Ge & Xing-ping Dai (2020) Fengbaisan suppresses endoplasmic reticulum stress by up-regulating SIRT1 expression to protect rats with chronic obstructive pulmonary diseases,

Cited by 9 publications

References 22 publications

As a Modulator, Multitasking Roles of SIRT1 in Respiratory Diseases

As a Modulator, Multitasking Roles of SIRT1 in Respiratory Diseases

Plants used to treat respiratory diseases introduced by Bolivian and Chinese immigrants in the Metropolitan Area of Buenos Aires, Argentina

Endoplasmic Reticulum Stress in Chronic Obstructive Pulmonary Disease: Mechanisms and Future Perspectives

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