Fenfluramine

Pinder, Ruth; Brogden, Rex N.; Sawyer, Phyllis R.; Speight, T. M.; Avery, G. S.

doi:10.2165/00003495-197510040-00001

Cited by 192 publications

(11 citation statements)

References 115 publications

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“…The use of allopathic and pharmacological drugs has become a popular means to overcome excess weight gain [11]. While these drugs generally are effective, severe adverse toxicities may limit their overall usefulness [12,13].…”

Section: Introductionmentioning

confidence: 99%

Review Article: Herbal Approach for Obesity Management

Chandrasekaran¹,

Vijayalakshmi²,

Prakash³

et al. 2012

AJPS

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Obesity, a complex interplay between environmental and genetic factors and is associated with significant morbidity and mortality. Usage of herbs for the management of obesity in the recent times is attracting attention. A web and manual based literature survey was conducted to assess the amount of information available on the herbal products for weight management. Traditional literature, PubMed, Scopus, Google scholar databases were screened up to February 2012. The search words were "obesity", "herbal medicine/products/extracts", "medicinal plants", "traditional medicine", "Ayurvedic medicine" without narrowing/limiting searching words or elements. Publications only with abstracts/full articles and books were reviewed in the search. Based on the available literature, for many of the herbal and weight loss products, there is little published information and there have been no clinical trials or the level of evidence is limited. Our literature survey also indicated that these herbal products fall under an acceptable level of evidence or with no scientific background at all, or they have a scientific rational but not to an acceptance level. Attempts were made in the review to define the features of possible herbal weight loss product. An ideal herbal anti obesity product should reduce the weight by 10% over placebo of treatment by showing an evidence of improvement of bio markers like blood pressure, lipids and glycemia without any side effects.

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Section: Introductionmentioning

confidence: 99%

Review Article: Herbal Approach for Obesity Management

Chandrasekaran¹,

Vijayalakshmi²,

Prakash³

et al. 2012

AJPS

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“…3). Its major metabolite, norfenfluramine, is believed to be the main active form in humans [19]. Propylhexedrine is prepared by catalytic hydrogenation of (±)-or (-)-ephedrine in a strong mineral acid [20].…”

Section: β-Phenylisopropylaminesmentioning

confidence: 99%

Anti-Obesity Drugs

Houlihan¹

2000

Ullmann's Encyclopedia of Industrial Chemistry

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“…Three doses of fenfluramine were administered to provide various circulating concentrations of fenfluramine in lean and obese mice, since steady state is influenced both by body weight and storage in adipose tissue (21). Our observation of reduced body weight only in lean mice receiving the highest dose of fenfluramine is not in agreement with the report of Bizzi et al (22), who observed that fenfluramine administered on the basis of total body weight to lean and gold-thioglucose (GTG) obese mice was more effective in reducing food intake in obese mice than in lean mice.…”

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confidence: 99%

Fenfluramine Effects on Insulin Resistance and Lipogenesis in Genetically Obese (ob/ob) Mice

Pasquine

Thenen

1981

Experimental Biology and Medicine

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Treatment of 15-week-old obese and lean mice with the amphetamine derivative fenfluramine (15,25, and 40 mg/kg body wt, ip) for 14 days did not reduce body weight, except in lean mice receiving 40 mg/kg. In vivo insulin sensitivity, measured as the ability of exogenous insulin (1 IUIkg body wt, ip) to lower blood glucose, was improved in obese mice receiving the two higher doses (25 and 40 mg/kg) of fenfluramine for 14 days, when compared to untreated obese mice. There was no change in insulin sensitivity between treated and untreated lean mice. This improvement, seen in obese mice which did not lose weight, demonstrates an effect of this drug distinct from its anorexigenic properties. On Day 21 of fenfluramine treatment, the in vivo rates of fatty acid synthesis were determined by injecting 3 H 2 0 ip and measuring the amount of 3H incorporated into fatty acids over a 1-hr period. The rates of fatty acid synthesis per gram of liver and adipose tissue of obese and lean mice receiving 40 mg/kg fenfluramine were unchanged when compared to sham-injected controls. However, fat depletion was observed in epididymal fat pads of treated (40 mg/kg) lean mice, indicating either reduced lipid deposition or stimulated lipolysis in this group. In vitro, a therapeutic concentration (100 ng/ml) of fenfluramine increased insulin-stimulated conversion of [U-14C]glucose to fatty acids but not CO, and total lipids in isolated adipocytes from lean but not obese mice. These results indicate that the reduction of insulin resistance in obese mice treated with fenfluramine does not influence rates of lipogenesis in liver and adipose tissue but may be associated with increased insulin sensitivity of other tissues such as muscle.24 1 0037-9727181102024 1-08$01 .OO/O

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Fenfluramine

Cited by 192 publications

References 115 publications

Review Article: Herbal Approach for Obesity Management

Review Article: Herbal Approach for Obesity Management

Anti-Obesity Drugs

Fenfluramine Effects on Insulin Resistance and Lipogenesis in Genetically Obese (ob/ob) Mice

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