Fendosal (HP 129): A potent anti-inflammatory and analgesic compound

Abstract

Fendosal (HP 129) is one of a series of potent non-steroidal anti-inflammatory agents. Fendosal was compared with aspirin in several anti-inflammatory and analgesic bioassay procedures. Results indicate that fendosal has an anti-inflammatory activity 1.4 times greater than does aspirin in carrageenan-induced rat paw edema. Fendosal is 6.9 to 9.5 times more active than aspirin in the prophylactic and therapeutic adjuvant-induced polyarthritis models of chronic inflammation. The analgesic activity of fendosal is considered to be superior to that of aspirin, with the advantage of a prolonged duration of action. The gastric-irritating properties of fendosal are very low in comparison with those of aspirin. Fendosal has a much wider separation of effective and gastric-irritating doses than does aspirin.

Small molecules inhibitors of plasminogen activator inhibitor-1 – An overview

“…This molecule also called Fendosal was already described as a non-steroidal anti-inflammatory agent [65] and has later been patented for the treatment of Alzheimer disease [66] as well as for ocular disorders [67].…”

Characterization and Comparative Evaluation of a Novel PAI-1 Inhibitor

“…1), in comparison to four LMW compounds [i. e. XR1853 (38), AR-H029953XX (42), XR5118 (39,41) and one peptide TVASS (35)], using different assays. This compound [in retrospect found to be identical to Fendosal, previously reported as a non-steroidal anti-inflammatory agent (48)] was identified subsequent to a screening of 20.000 synthetic compounds for their effect on PAI-1 activity using an immunofunctional assay (see Materials and Methods).…”

“…Chemical structure of HP129(48) SDS-PAGE : Preincubation of 9 l of wtPAI-1 (4.96 M total PAI-1) with 1 l of either compound or buffer for 30 min at 25°C or at 37°C. 10 l of this solution was incubated with 10 l of t-PA (7.7 M) for 30 min at 37°C.…”