Fenazaquin Acaricide Specific Binding Sites in NADH: Ubiquinone Oxidoreductase and Apparently the ATP Synthase Stalk

Wood, E.; Latli, Bachir; Casida, John E.

doi:10.1006/pest.1996.0017

Cited by 55 publications

(30 citation statements)

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“…Reciprocal crossing experiments between TUK4 and GSS showed that the resistance phenotype is incompletely dominant and capable of being inherited both paternally and maternally. METI compounds attack a target in the mitochondrial respiratory pathway9, 10 and, as mitochondrial DNA is inherited only from the female gamete, the fact that resistance is inherited paternally excludes the possibility that it is encoded from the mitochondrial, rather than the nuclear genome.…”

Section: Discussionmentioning

confidence: 99%

“…These inhibit complex I (NADH: ubiquinone oxidoreductase) of the mitochondrial respiratory pathway, probably by binding to a subunit of the associated electron transport particles 9. 10 In recent years, five such compounds have been developed as acaricides and released commercially in close succession. The pyrazolecarboxamide, tebufenpyrad was discovered in 1987 and by 1993 was being used in France, Belgium, Switzerland and Japan 11.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and inheritance of resistance to METI‐acaricides in European strains of the two‐spotted spider mite (Tetranychus urticae) (Acari: Tetranychidae)

Devine

Barber

Denholm

2001

Pest Management Science

115

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A strain of Tetranychus urticae (Koch; Acari: Tetranychidae), collected from hops (Humulus humuli L; Cannabaceae) in England with a short history of tebufenpyrad use, exhibited resistance to four METI (mitochondrial electron transport inhibitor)-acaricides; tebufenpyrad, pyridaben, fenazaquin and fenpyroximate. Resistance factors for these compounds in a microimmersion assay were 46, 346, 168 and 77 respectively, and corresponded to those exhibited by a Japanese METI-acaricide-resistant reference strain. Levels of resistance remained stable without further selection, and selection with tebufenpyrad did not increase them. The UK strain was also resistant (c 6-fold) to bifenthrin. Crosses of homozygous, diploid females with hemizygous, haploid males showed that, in the UK strain, METI-acaricide resistance was paternally and maternally inherited, and was an incompletely dominant trait. Another tebufenpyrad-resistant strain from the UK, originating from a chrysanthemum nursery (Chrysanthemum foeniculaceum Giseke; Asteraceae) was collected eight months later at a site c 210 km distant from the first. These are the first published incidences of METI-acaricide resistance in Europe and implications for the future use of these compounds are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incidence and inheritance of resistance to METI‐acaricides in European strains of the two‐spotted spider mite (Tetranychus urticae) (Acari: Tetranychidae)

Devine

Barber

Denholm

2001

Pest Management Science

115

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“…1 and 2) as standards with cancer chemopreventive activity. NADH:ubiquinone oxidoreductase activity was determined as NADH oxidation (loss of NADH absorbance at 340 nM) by a standard procedure (20) with bovine heart electron transport particles (ETP) (21). The inhibitor and enzyme (40 g of ETP protein) in 50 mM phosphate buffer (pH 7.4) with 0.25 M sucrose (1.0 ml) were incubated for 5 min at 25°C, then NADH (28 M final concentration) was added, and the absorbance loss was monitored for 3 min.…”

Section: Methodsmentioning

confidence: 99%

Anticancer action of cubé insecticide: Correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities

Fang

Casida

1998

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

165

130

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Rotenone and rotenoid-containing botanicals, important insecticides and fish poisons, are reported to have anticancer activity in rats and mice. The toxic action of rotenone is attributed to inhibition of NADH:ubiquinone oxidoreductase activity and the purported cancer chemopreventive effect of deguelin analogs has been associated with inhibition of phorbol ester-induced ornithine decarboxylase (ODC) activity. This study defines a possible relationship between these two types of activity important in evaluating the toxicology of rotenoid pesticides and the suitability of the anticancer model. Fractionation of cubé resin (the commercial rotenoid pesticide) establishes that the activity in both assays is due primarily to rotenone (IC 50 ‫؍‬ 0.8-4 nM), secondarily to deguelin, and in small part to rotenolone and tephrosin. In addition, the potency of 29 rotenoids from cubé insecticide for inhibiting NADH:ubiquinone oxidoreductase in vitro assayed with bovine heart electron transport particles satisfactorily predicts their potency in vivo in the induced ODC assay using noncytotoxic rotenoid concentrations with cultured MCF-7 human breast cancer cells (r ‫؍‬ 0.86). Clearly the molecular features of rotenoids essential for inhibiting NADH:ubiquinone oxidoreductase are similar to those for blocking ODC induction. This apparent correlation extends to 11 f lavonoids and stilbenoids from cubé resin (r ‫؍‬ 0.98) and genistein and resveratrol except for lower potency and less selectivity than the rotenoids relative to cytotoxicity. These findings on cubé insecticide constituents and our earlier study comparing rotenone and pyridaben miticide indicate that inhibition of NADH:ubiquinone oxidoreductase activity lowers the level of induced ODC activity leading to the antiproliferative effect and anticancer action.

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“…Although these chemicals belong to different chemical families, their mode of action is similar, i.e. inhibiting complex 1 of the respiratory chain, hence their classification in the group of Mitochondrial Electron Transport Inhibitors (METIs) (Hollingworth and Ahammadsahib 1995;Wood et al 1996). These four compounds became very popular and are used world wide due to their high efficacy, quick knockdown and long residual control.…”

Section: Acaricide Portfoliomentioning

confidence: 98%

The control of eriophyoid mites: state of the art and future challenges

Leeuwen

Witters²,

Nauen

et al. 2009

Exp Appl Acarol

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The superfamily of the Eriophyoidea is a large and diverse group of mites, including a number of species of economic importance, mainly on perennial plants in agriculture and forestry. This review focuses on the economic importance and pest status of this group of mites, with emphasis on some genera. The available acaricide portfolio is reviewed and the influence of EU legislation policy on the sustainable control of Eriophyoidea is investigated. Possible generic guidelines for sustainable control and resistance management with special reference to the European situation are discussed. Recent advances in biological and integrated control of eriophyid mite pests and the implementation of these techniques in crops are explored. Furthermore, the relevance of studies on behaviour, epidemiology and diagnostics in general terms and as a strategic necessity is pointed out.

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Fenazaquin Acaricide Specific Binding Sites in NADH: Ubiquinone Oxidoreductase and Apparently the ATP Synthase Stalk

Cited by 55 publications

References 0 publications

Incidence and inheritance of resistance to METI‐acaricides in European strains of the two‐spotted spider mite (Tetranychus urticae) (Acari: Tetranychidae)

Incidence and inheritance of resistance to METI‐acaricides in European strains of the two‐spotted spider mite (Tetranychus urticae) (Acari: Tetranychidae)

Anticancer action of cubé insecticide: Correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities

The control of eriophyoid mites: state of the art and future challenges

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