Femtosecond laser microhole drilling inside a fused silica optical fiber with optical inner surface quality

Shiraishi, Masahiko; Goya, Kenji; Nishiyama, Michiko; Kubodera, Shoichi; Watanabe, Kazuhiro

doi:10.1007/s00339-016-0352-9

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…Ablation processing by ultra-short pulse laser is effective in creating a space of a micrometer scale, at an arbitrary position, of a transparent material such as the optical fiber [21,22]. For instance, a micro through-hole was fabricated into a glass optical fiber without the material breaking off, by using femtosecond laser drilling [23]. Subsequently, optical extinction spectra peculiar to the GNPs were obtained by injection into the micro through-hole [24].…”

Section: Introductionmentioning

confidence: 99%

Picoliter Cuvette inside an Optical Fiber to Track Gold Nanoparticle Aggregation for Measurement of Biomolecules

Shiraishi

Watanabe

Kubodera

2019

Sensors

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This study demonstrated a measurement approach for biomolecules at the picoliter scale, using a newly developed picoliter cuvette inside an optical fiber constructed via near-ultraviolet femtosecond laser drilling. The sensing capacity was estimated to be within 0.4–1.2 pL due to an optical path length of 3–5 microns, as measured by scanning electron microscopy (SEM). The picoliter cuvette exhibited a change in the optical extinction spectrum after addition of biomolecules such as L-cysteine, in conjunction with a gold nanoparticle (GNP) dispersion solution, following a simple measurement configuration involving a small white light source and a compact spectrometer. A linear attenuation of the spectral dip near a wavelength of 520 nm was observed as the L-cysteine concentration was increased at 4 wt% of the GNP mass concentration. The measurement resolution of the concentration using the picoliter cuvette was evaluated at 0.125 mM. The experimental results showed the difference in aggregation processes caused by a different concentration of GNPs. Moreover, they revealed the ability of the picoliter cuvette to verify whether the concentration of GNPs in the liquid sample correspondingly determines homogeneous or inhomogeneous GNP aggregation, as supported by SEM observation and numerical calculations based on Mie theory.

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