Femtosecond laser induced flexibility change of human donor lenses

Schumacher, Silvia; Oberheide, Uwe; Fromm, Michael; Ripken, Tammo; Ertmer, W.; Gerten, Georg; Wegener, Alfred; Lubatschowski, Holger

doi:10.1016/j.visres.2009.04.028

Cited by 35 publications

(33 citation statements)

References 38 publications

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“…9,10 A similar strategy is applied in the concept of fs-laser presbyopia treatment, which aims to restore the elasticity of the lens by inducing laser disruptions in the hardened lens nucleus. [11][12][13] Moreover, fs-laser-induced cuts within the vitreous body may reduce vitreous traction and are therefore discussed as a preventive therapy for posterior vitreous detachment.…”

Section: Introductionmentioning

confidence: 99%

Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing

et al. 2014

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In recent years, femtosecond (fs)-lasers have evolved into a versatile tool for high precision micromachining of transparent materials because nonlinear absorption in the focus can result in refractive index modifications or material disruptions. However, when high pulse energies or low numerical apertures are required, nonlinear side effects such as self-focusing, filamentation or white light generation can decrease the modification quality. In this paper, we apply simultaneous spatial and temporal focusing (SSTF) to overcome these limitations. The main advantage of SSTF is that the ultrashort pulse is only formed at the focal plane, thereby confining the intensity distribution strongly to the focal volume and suppressing detrimental nonlinear side effects. Thus, we investigate the optical breakdown within a water cell by pump-probe shadowgraphy, comparing conventional focusing and SSTF under equivalent focusing conditions. The plasma formation is well confined for low pulse energies ,2 mJ, but higher pulse energies lead to the filamentation and break-up of the disruptions for conventional focusing, thereby decreasing the modification quality. In contrast, plasma induced by SSTF stays well confined to the focal plane, even for high pulse energies up to 8 mJ, preventing extended filaments, side branches or break-up of the disruptions. Furthermore, while conventional focusing leads to broadband supercontinuum generation, only marginal spectral broadening is observed using SSTF. These experimental findings are in excellent agreement with numerical simulations of the nonlinear pulse propagation and interaction processes. Therefore, SSTF appears to be a powerful tool to control the processing of transparent materials, e.g., for precise ophthalmic fs-surgery.

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Section: Introductionmentioning

confidence: 99%

Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing

et al. 2014

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“…Moreover, the flexibility of the lens increased depending on the particular cutting pattern [10,11].…”

Section: Introductionmentioning

confidence: 99%

Femtosecond lentotomy: generating gliding planes inside the crystalline lens to regain accommodation ability

Lubatschowski

Schumacher

Fromm

et al. 2010

Journal of Biophotonics

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Based on Helmholtz Theory for accommodation the increasing sclerosis of lens nucleus and cortex is the main cause for the developments of presbyopia. Existing therapies, however, do not reverse the stiffness of the crystalline lens and thus do not regain real accommodation ability. A new approach to restore the flexibility of the lens could be realized by photodisruption using ultrafast laser pulses. This process, known as fs-lentotomy, was used to create micro-incisions which act as gliding planes inside the crystalline lens without opening the eye globe.

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“…The first experimental results were promising. [6][7][8] Studies show that the procedure can be applied successfully in porcine, 8 human cadaver donor, 9 and rabbit 10 eyes. The laser microincisions inside the crystalline lens were detectable on OCT and Scheimpflug imaging, which emphasizes the integral role these technologies play in targeting and characterizing postoperative tissue effects.…”

Section: Discussionmentioning

confidence: 99%

“…8 The microincisions inside the lens tissue are created with femtosecond laser pulses in a manner similar to flap generation in laser in situ keratomileusis. 8 The first in vitro studies of porcine 8 and human 9 donor lenses showed increased lens deformability after treatment.…”

mentioning

confidence: 99%

Visualization of femtosecond laser pulse–induced microincisions inside crystalline lens tissue

Stachs

Schumacher

Hovakimyan

et al. 2009

Journal of Cataract and Refractive Surgery

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Femtosecond laser induced flexibility change of human donor lenses

Abstract: The creation of gliding planes with a fs laser inside the crystalline lens tissue can change the deformation ability of the lens. This might be an indication for a possible method to treat presbyopia in future.

Cited by 35 publications

References 38 publications

Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing

Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing

Femtosecond lentotomy: generating gliding planes inside the crystalline lens to regain accommodation ability

Visualization of femtosecond laser pulse–induced microincisions inside crystalline lens tissue

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