Femtosecond ionization mass spectrometry for chromatographic detection

Imasaka, Totaro; Imasaka, Tomoko

doi:10.1016/j.chroma.2021.462023

Cited by 10 publications

(8 citation statements)

References 50 publications

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“…Helium was used as a carrier gas at a flow rate of 1.0 mL min –1 . The analytes eluting from the column were measured by a linear-type TOFMS (mass resolution, m /Δ m = 1500) developed in this laboratory. , An assembly of microchannel plates (F4655-11, Hamamatsu Photonics, Shizuoka, Japan) was used as an ion detector. The temperature of a GC inlet as well as the interface between the GC and the MS was kept at 250 °C for a sample containing phenethylamine, 3,4-metylenedioxyphenethylamine, tryptamine, and nicotine, while the temperatures were decreased to 200 °C for a sample containing N -methylephedrine (and nicotine) to reduce thermal decomposition.…”

Section: Methodsmentioning

confidence: 99%

“…Photoionization has been developed as a new technique for soft ionization in MS. , Photodissociation dynamics and ionization efficiency have been studied using a variety of pulse lasers as the ionization sources. − A technique based on single photon nanosecond/femtosecond ionization is developed to enhance a molecular ion. , A hydrogen laser (ca. 8 eV) has been employed for this purpose .…”

Section: Introductionmentioning

confidence: 99%

“…14−16 The fragmentation can be reduced by decreasing the ionization energy from 70 to 10 eV. 17 Photoionization has been developed as a new technique for soft ionization in MS. 18,19 Photodissociation dynamics and ionization efficiency have been studied using a variety of pulse lasers as the ionization sources. 20−23 A technique based on single photon nanosecond/femtosecond ionization is developed to enhance a molecular ion.…”

Section: ■ Introductionmentioning

confidence: 99%

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Comprehensive Analysis of Analogues of Amine-Related Psychoactive Substances Using Femtosecond Laser Ionization Mass Spectrometry

Madunil

Imasaka

2021

J. Am. Soc. Mass Spectrom.

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Amine-related psychoactive molecules contain N–Cα and Cα–Cβ bonds, which easily dissociate to form various fragment ions in electron ionization mass spectrometry (EIMS). Therefore, observing a molecular ion and then determining the molecular weight of the analyte is difficult. In this study, we examined phenethylamine, 3,4-methylenedioxyphenethylamine, tryptamine, N-methylephedrine, and nicotine as well as analogues of amine-related psychoactive substances using EIMS and femtosecond laser ionization mass spectrometry (fs-LIMS) combined with gas chromatography for comprehensive analysis. A molecular ion was clearly observed in fs-LIMS for all of these compounds, which was in contrast to EIMS providing fragment ions dominantly (no molecular ion was observed for N-methylephedrine). This favorable result was obtained by adjusting the laser wavelength to the optimal value for two-photon ionization to minimize the excess energy remaining in the molecular ion. It therefore appears that fs-LIMS is superior to EIMS in terms of observing a molecular ion and would be potentially useful for identifying a variety of amine-related psychoactive substances, some of which are illegal and are of interest in the field of forensic science.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comprehensive Analysis of Analogues of Amine-Related Psychoactive Substances Using Femtosecond Laser Ionization Mass Spectrometry

Madunil

Imasaka

2021

J. Am. Soc. Mass Spectrom.

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“…According to the physical and chemical properties of the analyte and the different internal energy transfer modes in the ionization process, different ionization methods can be used to ionize sample meteorological molecules into charged ions. Common ion sources include electron bombardment (EI) [243], chemical ionization (CI) [244], fast atom bombardment (FAB) [245], Matrix Assisted Laser Desorption Ion Sources (MALDI) [246], and Electrospray Ionization (ESI) [247].…”

Section: Mass Spectrometry (Ms)mentioning

confidence: 99%

Extraction and Analysis of Chemical Compositions of Natural Products and Plants

Zhang,

Zhao,

Dai

et al. 2023

Separations

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There are many types of natural plants in nature that contain a variety of effective and complex chemical components. These constituents can be categorized as organic acids, volatile oils, coumarins, steroids, glycosides, alkaloids, carbohydrates, phytochromes, etc., all of which play important roles in the fields of pharmaceuticals, food, nutraceuticals, and cosmetics. The study of extraction and chemical composition analysis of natural products is important for the discovery of these active ingredients and their precursors. Therefore, the aim of this article is to review the status of research on the extraction, separation and purification, and structural identification of natural products, to provide a reference for the study of natural products.

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“…Novel frequency doubling of the third harmonic of a Nd:YAG laser (177.3 nm) also holds the potential to be used in EGA–MS. Even femtosecond laser ionization was proposed for GCMS …”

Section: Laser-based Photoionizationmentioning

confidence: 99%

Review on Evolved Gas Analysis Mass Spectrometry with Soft Photoionization for the Chemical Description of Petroleum, Petroleum-Derived Materials, and Alternative Feedstocks

et al. 2021

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Modern industry strongly relies on the molecular analysis of fossil petroleum and petroleum-derived materials. In the context of a circular economy and carbon neutrality, the chemical description of alternative feedstock materials, such as waste plastic and biomass pyrolysis oils, increases in importance. Moreover, online monitoring of the thermochemical and catalytic conversion processes has gained rising attention. In this framework, evolved gas analysis (EGA) concepts with soft photoionization mass spectrometry (PIMS) were successfully deployed for numerous challenges. On the one hand, photoionization is a highly versatile technique and allows for “soft” ionization of the analyte molecule, preserving the molecular information. On the other hand, multiple evolved gas analysis concepts exist with unique benefits, such as the mass loss information in thermogravimetry coupling, high-throughput in direct inlet probe concepts, or straightforward reactor monitoring, allowing for direct online insights into pyrolytic transformation processes. Hence, this review aims to summarize the recent work in the field of EGA–PIMS. After technical description of the multiple photoionization and thermal analysis concepts, applied studies are summarized, discussed, and evaluated. Besides fossil fuels, studies on alternatives from renewable materials, such as biomass pyrolysis, plastic pyrolysis oils, and recycling processes, are reviewed. Finally, future perspectives on this field are given, highlighting the importance of those soft ionization schemes together with state-of-the-art detection by high-resolution mass spectrometry in the field of energy and fuels research.

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Femtosecond ionization mass spectrometry for chromatographic detection

Cited by 10 publications

References 50 publications

Comprehensive Analysis of Analogues of Amine-Related Psychoactive Substances Using Femtosecond Laser Ionization Mass Spectrometry

Comprehensive Analysis of Analogues of Amine-Related Psychoactive Substances Using Femtosecond Laser Ionization Mass Spectrometry

Extraction and Analysis of Chemical Compositions of Natural Products and Plants

Review on Evolved Gas Analysis Mass Spectrometry with Soft Photoionization for the Chemical Description of Petroleum, Petroleum-Derived Materials, and Alternative Feedstocks

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