2018
DOI: 10.1021/acssensors.7b00918
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Femtomolar Detection by Nanocoated Fiber Label-Free Biosensors

Abstract: The advent of optical fiber-based biosensors combined with that of nanotechnologies has provided an opportunity for developing in situ, portable, lightweight, versatile, and high-performance optical sensing platforms. We report on the generation of lossy mode resonances by the deposition of nanometer-thick metal oxide films on optical fibers, which makes it possible to measure precisely and accurately the changes in optical properties of the fiber-surrounding medium with very high sensitivity compared to other… Show more

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Cited by 217 publications
(108 citation statements)
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References 35 publications
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“…angles approaching 90º [5]. This explains why most of the experimental work on LMRs uses optical fibre instead of the Kretschmann-Raether configuration [7,[10][11][12][13][14][15]. With this last configuration, it is very difficult to impinge light at nearly 90º.…”
mentioning
confidence: 99%
“…angles approaching 90º [5]. This explains why most of the experimental work on LMRs uses optical fibre instead of the Kretschmann-Raether configuration [7,[10][11][12][13][14][15]. With this last configuration, it is very difficult to impinge light at nearly 90º.…”
mentioning
confidence: 99%
“…In the field of biosensing, SnO 2 has also been frequently studied. An immunoglobulin G (IgG) sensor using tin oxide over two different fiber structures was reported in [29]. Here, a configuration based on a 200 µm core MMF was capable to achieve a LOD of 0.9 µg/L, while the setup based on a D-shaped fiber reached a LOD of 0.15 µg/L, which are both comparatively better than the results obtained using an ITO coating.…”
Section: Tin Oxidementioning
confidence: 91%
“…This device showed a sensitivity of up to 169.93 nm/mg L −1 and achieved a limit of detection (LOD) of 0.0625 mg/L. Another example is an immunoglobulin G sensor fabricated on an ITO-coated MMF, which was functionalized by adding a poly(methyl methacrylate) layer and immobilized antibodies, achieving a LOD of 3.5 μg/L [29].…”
Section: Indium Tin Oxide (Ito)mentioning
confidence: 99%
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“…The LMR wavelength highly depends on the properties of ITO and external medium, i. e., its refractive index (RI), as well as any thin film formed on its surface. These advantages make application of the LMR‐based structure in label‐free biosensing possible . When the device is supported by EC setup, it offers the capability of receiving enhanced information about the investigated analyte compared to simple optical interrogation.…”
Section: Introductionmentioning
confidence: 99%