Femoral atherosclerosis in an older British population: prevalence and risk factors

Leng, G. C.; Papacosta, Olia; Whincup, Peter H.; Wannamethee, S. Goya; Walker, Mary; Ebrahim, Shah; Nicolaides, Andrew; Dhanjil, Surinder; Griffin, Maura; Belcaro, Gianni; Rumley, Ann; Lowe, G. D. O.

doi:10.1016/s0021-9150(99)00447-5

Cited by 75 publications

(46 citation statements)

References 23 publications

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“…The prevalence of concomitant cardiovascular disease (previous ischemic heart disease, angina, or stroke) was higher in the group with femoral plaque. 18 These findings are not comparable with our results, because such small vessel irregularities will not be visualized with WBMRA. In our study, 2% of the common femoral arteries were affected by atherosclerosis.…”

Section: Discussioncontrasting

confidence: 93%

The Prevalence and Quantification of Atherosclerosis in an Elderly Population Assessed by Whole-Body Magnetic Resonance Angiography

Hansen

Wikström

Johansson

et al. 2007

ATVB

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Objective-The principal aim of the present study was to explore the feasibility of using whole-body magnetic resonance angiography to assess atherosclerosis in different vascular territories in a cohort of elderly. Methods and Results-Three hundred six 70-year-old subjects (145 women, 161 men) recruited from a population-based cohort study (Prospective Investigation of the Vasculature in Uppsala Seniors, ie, the PIVUS study) underwent 1.5-T whole-body magnetic resonance angiography with gadodiamide. The arteries were divided into 26 segments. In total, 7956 vessel segments were evaluated with 7900 segments (99.3%) possible to evaluate. Of these, 7186 segments (91%) were normal. Luminal narrowing of Ն50% was observed in 9 (1.5%) of the renal arteries, 12 (1.8%) of the carotid arteries, in 31 segments (1.1%) of the pelvic/upper leg territories, and in 136 segments (6.2%) of territories in the lower leg. Approximately one-third of the sample had no vascular abnormalities, one-third had stenoses of Ͻ50%, and the remainder had stenoses Ն50% or occlusions. Six subjects (2%) had aortic aneurysms. In subjects without evident vascular disease, 26% had significant vascular abnormalities. Conclusions

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Section: Discussioncontrasting

confidence: 93%

The Prevalence and Quantification of Atherosclerosis in an Elderly Population Assessed by Whole-Body Magnetic Resonance Angiography

Hansen

Wikström

Johansson

et al. 2007

ATVB

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“…33 Except for high SBP, high MBP was also associated with plaques in this study population. Apart from BP, male gender 5,12,28,30 and smoking [13][14]30 are well-established risk factors for atheromatous plaques. Carotid atherosclerosis measured by ultrasound appears to be associated with coronary artery disease 34 and to predict myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

Blood pressure and atherosclerotic plaques in carotid, aortic and femoral arteries in elderly Finns with diabetes mellitus or impaired glucose tolerance

et al. 2004

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The aim of the study was to evaluate the occurrence of atheromatous plaques in carotid, aortic and femoral arteries, focusing on blood pressure (BP). The study subjects consisted of 65-year-old Finns drawn from a population-based cohort. Ultrasonographic measurements were performed on 54 diabetic subjects, 97 subjects with impaired glucose tolerance (IGT) and 57 normoglycaemic subjects (NGT). High systolic BP (SBP) was defined as X160 mmHg and high diastolic BP as X95 mmHg. High pulse pressure (PP) was defined as the highest tertile (X75 mmHg) of PP and high mean BP (MBP) as the highest tertile (X111 mmHg) of MBP. The prevalence of atheromatous plaques was 77% (160/208) in carotid arteries, 94% (195/208) in aorta and 77% (161/ 208) in femoral arteries. A total of 64% (134/208) of the subjects had plaques in both carotid and femoral arteries, and they were compared with those who had plaques in 0-1 of these arteries. In addition to male gender and long-lasting smoking, the occurrence of plaques in both carotid and femoral arteries were associated with high SBP and high MBP. According to the results of multiple regression analyses, the adjusted odds ratio for plaques in both carotid and femoral arteries was 3.1 (95% CI 1.5-6.5) in subjects with high SBP compared to those with lower SBP. When SBP was replaced by high MBP, the adjusted odds ratio for it was 2.3 (95% CI 1.1-4.8).

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“…Remodeling of artery structure in accordance with changing physiological demands has been extensively studied in animal models and has also been demonstrated in human leg arteries. However, almost two-thirds of the population in late middle age has evidence of atherosclerotic disease of the femoral artery (49), and normal artery wall structure cannot be maintained in plaque regions. In healthy subjects, leg exercise increased the diameter and reduced intima-media thickness of the femoral artery.…”

Section: Pathophysiological Changes In Conduit Arteriesmentioning

confidence: 99%

Marriage of resistance and conduit arteries breeds critical limb ischemia

Coats¹,

Wadsworth²

2005

American Journal of Physiology-Heart and Circulatory Physiology

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Femoral atherosclerosis in an older British population: prevalence and risk factors

Cited by 75 publications

References 23 publications

The Prevalence and Quantification of Atherosclerosis in an Elderly Population Assessed by Whole-Body Magnetic Resonance Angiography

The Prevalence and Quantification of Atherosclerosis in an Elderly Population Assessed by Whole-Body Magnetic Resonance Angiography

Blood pressure and atherosclerotic plaques in carotid, aortic and femoral arteries in elderly Finns with diabetes mellitus or impaired glucose tolerance

Marriage of resistance and conduit arteries breeds critical limb ischemia

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