Female Urethral Diverticulum Carcinoma: A Case Report and Literature Review

Kasahara, Ryo; Tabei, Tadashi; Tsuura, Yukio; Kobayashi, Kazuki

doi:10.1155/2017/8918492

Cited by 3 publications

(3 citation statements)

References 7 publications

(7 reference statements)

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“…20 Chemotherapy used as neoadjuvant with or without radiation has been shown to be superior to the adjuvant options. 20 Commonly used platinum-based chemotherapy options include the 5-FU/leucovorin/cisplatin, 10 GC, 26,29 MVAC, 26 and paclitaxel/ifosfamide/cisplatin 30 with the only comparison between GC and MVAC showing benefits to similar degrees. 26 GC or MVAC combinations may be used in patients with previous sensitivity to platinum-based therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies reported benefits in patients treated with platinum-based therapy for urogenital malignancies including the urethral diverticular carcinoma. 10,20,26,[28][29][30] It is important here to note that some cancers may be platinum refractory, and proper identification of treatment options following a failure in platinum-refractory cases should be decided. The role of chemotherapy also varies whether it is used as adjuvant or neoadjuvant with or without radiation.…”

Section: Chemotherapymentioning

confidence: 99%

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A Rare Case of Advanced Urethral Diverticular Adenocarcinoma and a Review of Treatment Modalities

Oluyadi

Ramachandran

Gotlieb

2019

Journal of Investigative Medicine High Impact Case Reports

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Female urethral diverticular cancer is a very rare entity with only around 100 cases reported so far in literature and accounts for <1% of all malignancies. In this article, we present a 47-year-old African American female with repeated hospital visits for urinary retention, hematuria, and urinary tract infections. Initial computed tomography imaging and cystoscopy was unremarkable except for a distended urinary bladder. Subsequent magnetic resonance imaging and corresponding cystoscopy eventually indicated the presence of a urethral diverticulum. She underwent urethral diverticulectomy and was found to have a mass arising from urethral diverticulum extending to vaginal walls. Her biopsy was suggestive of invasive adenocarcinoma in advanced stages, for which she subsequently underwent a total pelvic exenteration. Next-generation sequencing of the tumor showed CDKN2A/B loss, MSI-stable, and low TMB, thereby ruling out the options for targeted therapies. Extensive literature search and expert opinions were sought for her case since no consensus exists regarding the optimal therapeutic approach due to the rarity of this tumor. A final decision was made to treat her with platinum-based chemotherapy. Different treatment approaches including neoadjuvant chemoradiation followed by surgery, surgery followed by adjuvant chemotherapy, and surgery followed by chemoradiation have been tried. Platinum-based chemotherapy has generally been preferred based on an extensive literature search. Multimodality treatment approach seems to be the current approach to management for advanced stages for better overall survival. This case illustrates the challenges faced in making diagnosis and treatment decisions due to the rarity of this type of tumor and lack of consensus in the treatment approach.

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Section: Discussionmentioning

confidence: 99%

Section: Chemotherapymentioning

confidence: 99%

A Rare Case of Advanced Urethral Diverticular Adenocarcinoma and a Review of Treatment Modalities

Oluyadi

Ramachandran

Gotlieb

2019

Journal of Investigative Medicine High Impact Case Reports

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“…Some cases may involve infection, calculus, and/or malignant tumors. 2 Due to the short urethra and low probability of bladder stone formation, urinary stones in female urethral diverticulum are rare. We report a case of female urethral diverticulum with stones.…”

Section: Introductionmentioning

confidence: 99%

Female urethral diverticulum containing large calculi

Kimura

Kawaguchi

Momozono

et al. 2018

Urology Case Reports

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Urinary stones in female urethral diverticulum are rarely seen. We report a 79-year-old woman who presented with irritative lower urinary tract symptoms and vaginal cystocele with incontinence. The urethral stones in the diverticulum were successfully extracted through the trans-urethral route and anterior tension-free vaginal mesh was applied one month later. The patient has been well, with no lower urinary symptoms or incontinence for 4 months.

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Urethral diverticulum carcinoma in females—a case series and review of the English and Japanese literature

O’Connor¹,

Iatropoulou²,

Hashimoto³

et al. 2018

Transl. Androl. Urol.

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The aims of our study were to describe our case series of three urethral diverticulum carcinomas (UDC) in women and to review the literature on UDC in females to determine patient characteristics, presenting symptoms and outcomes along with optimal investigations and treatment modalities. A literature search was performed utilizing Medline, EMBASE and the Cochrane library for all papers including case reports on UDC in women published to date. The results along with those of our three cases are detailed. A total of 126 cases of UDC in women have been reported; 75% adenocarcinoma (Adenoca), 15% transitional cell carcinoma (TCC) and 10% squamous cell carcinoma (SCC). Median age at presentation was 53 years (range, 14–81 years). The commonest presenting symptoms were bleeding and retention. Cystoscopy, MRI and trans-urethral biopsy were the commonest methods of diagnosis. Treatment was radiotherapy +/− chemotherapy alone in 21%, local excision +/− radiotherapy in 44%, urethrectomy in 3% and anterior exenteration +/− radiotherapy in 32%. At last follow-up 63% were alive and well, 10% were alive with recurrent cancer and 25% had died from their disease. UDC is rare in women. It is predominantly adenocarcinoma. There is no established treatment and survival is at best moderate. An international registry and consensus on management is needed if this is to be improved.

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Female Urethral Diverticulum Carcinoma: A Case Report and Literature Review

Cited by 3 publications

References 7 publications

A Rare Case of Advanced Urethral Diverticular Adenocarcinoma and a Review of Treatment Modalities

A Rare Case of Advanced Urethral Diverticular Adenocarcinoma and a Review of Treatment Modalities

Female urethral diverticulum containing large calculi

Urethral diverticulum carcinoma in females—a case series and review of the English and Japanese literature

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