Female sex, young age, northern German residence, hypoglycemia and disabling diabetes complications are associated with depressed mood in the WHO-5 questionnaire – A multicenter DPV study among 17,563 adult patients with type 2 diabetes

Prinz, Nicole; Ebner, S.; Grünerbel, Arthur; Henkelüdecke, U.; Hermanns, Norbert; Hummel, Michael; Schäfer, Claus; Wagner, Christian von; Weiland, J; Welp, Reinhard; Holl, Reinhard W.

doi:10.1016/j.jad.2016.08.077

Cited by 20 publications

(22 citation statements)

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“…In a small study in an older population , those reporting severe hypoglycaemia had higher anxiety/depression scores (HARS/HDRS) compared with those reporting mild/moderate episodes. Severe hypoglycaemia was negatively associated with general emotional well‐being (WHO‐5) after adjusting for confounders in a large German sample , whereas no association was found in a small Dutch sample who were using oral agents alone . Effect sizes could not be calculated and the range of measures used precludes robust comparisons between studies.…”

Section: Resultsmentioning

confidence: 99%

“…Study designs were mainly cross‐sectional. Although six studies were prospective , for most of these, only cross‐sectional (baseline) data were relevant to the aims of the current review. In 16 studies the aim was to examine the association between hypoglycaemia and PROs.…”

Section: Resultsmentioning

confidence: 99%

“…Four included multiple countries in Europe and Asia . Sample sizes varied widely ( N = 71 to 17 563), and the largest was a multicentre study in Germany . Where reported, mean age was > 58 years, and two studies specifically recruited older participants .…”

Section: Resultsmentioning

confidence: 99%

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Impact of severe hypoglycaemia on psychological outcomes in adults with Type 2 diabetes: a systematic review

et al. 2019

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Aim Hypoglycaemia affects many people with Type 2 diabetes using insulin and other glucose‐lowering therapies. This systematic review examined the impact of severe hypoglycaemia (episodes requiring external assistance) on psychological outcomes (e.g. emotional well‐being, health status and quality of life) in adults with Type 2 diabetes. Methods MEDLINE Complete, PsycINFO and CINAHL databases were searched for peer‐reviewed empirical studies, published in English, reporting the occurrence and severity of hypoglycaemia and its relationship with patient‐reported outcomes (PROs) in adults with Type 2 diabetes. Data were extracted from published reports and analysed. Results Of 3756 potentially relevant abstracts, 29 studies met the inclusion criteria. Most reported cross‐sectional data and sample sizes varied widely (N = 71 to 17 563). Although definitions of mild and severe hypoglycaemia were largely consistent between studies, additional non‐standard categorizations (e.g. moderate, very severe) were apparent and recall periods varied. Overall, severe hypoglycaemia was associated with increased fear of hypoglycaemia and decreased emotional well‐being, health status and diabetes‐specific quality of life. Effect sizes show that the association with fear of hypoglycaemia was stronger than with general health status. Conclusions Notwithstanding the limitations of the empirical studies, these findings indicate that severe hypoglycaemia in adults with Type 2 diabetes (insulin‐ and non‐insulin‐treated) is associated with impaired psychological outcomes. Healthcare professionals should address the psychological impact of severe hypoglycaemia during clinical consultations, to support individuals to minimize exposure to, and the psychological consequences of, severe hypoglycaemia.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Impact of severe hypoglycaemia on psychological outcomes in adults with Type 2 diabetes: a systematic review

et al. 2019

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“…Through routine use of reliable and less time-consuming tools such as WHO-5 and PAID-5, detecting and monitoring depression and diabetes distress in diabetic patients could be realized so as to design targeted treatment regimen and achieve better health outcomes [ 21 ]. In Germany, WHO-5 has already been advised in the national guideline of diabetes care as the specific screening tool for depression due to its simplicity, easy applicability and rapid evaluation [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

How psychosocial outcomes impact on the self-reported health status in type 2 diabetes patients: Findings from the Diabetes Attitudes, Wishes and Needs (DAWN) study in eastern China

Guo¹,

Wang²,

Mao³

et al. 2018

PLoS ONE

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IntroductionThe deleterious effects of psychosocial outcomes on diabetic patients’ health have not been fully investigated yet. This study was aimed to explore how psychosocial outcomes impacted on the health status of Chinese patients with type 2 diabetes.MethodsA mix of stratified sampling and typical sampling were used to select diabetic patients in Jiangsu Province to conduct individual interviews. Health status was measured by EuroQol Visual Analogue Scale (VAS). Psychosocial outcomes were measured by instruments used in the Diabetes Attitudes, Wishes and Needs survey, including psychological well-being, diabetes distress, patient empowerment, self-management, and patient reported healthcare provision. Clinical characteristics measured included diabetes comorbidities, complications and treatment. OLS regression analyses were used to estimate how health status varied with different characteristics.ResultsAltogether 1614 patients with type 2 diabetes aged 18–65 years from 6 districts/counties in Jiangsu Province were included in the study. With general characteristics and clinical factors controlled for, psychological well-being among all psychosocial outcomes had the most significant association with health status, with a difference of 9.2 in VAS scores between likely depression and good well-being. VAS scores were also significantly lower in patients with high diabetes distress and significantly higher in those more frequently conducting physical activities. Other psychosocial outcomes were not significantly associated with health status.ConclusionsLikely depression and diabetes-related distress are negatively associated with health status while frequently conducting physical activities are positively associated with health status of type 2 diabetes patients aged 18–65 years from 6 districts/counties in Jiangsu Provinces. These findings underscore the necessity of undertaking routine assessment for depression and diabetes distress and prioritizing interventions on promoting regular physical activities in diabetic patients to improve health management and achieve better health outcomes.

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“…Diabetic foot patients are more likely to have depression and anxiety than diabetic patients without foot complications [ 9 , 10 ]. Diabetic foot ulceration disturbs the daily life of patients including changes in sleep pattern, impaired mobility, and interference with certain aspects of life such as sexuality, feelings of loneliness, powerlessness, anxiety and depression [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Anxiety and Depression Among Adult Patients With Diabetic Foot: Prevalence and Associated Factors

Ahmad¹,

Abujbara²,

Jaddou

et al. 2018

J Clin Med Res

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BackgroundDiabetic foot is a frequent complication of diabetes mellitus with subsequent disturbances in the daily life of the patients. The co-existence of depression and anxiety among diabetic foot patients is a common phenomenon and the role of each of them in perpetuating the other is highlighted in the literature. Our study aimed to determine the prevalence rates of anxiety and depression, and to examine the associated risk factors among diabetic foot patients.MethodsThis is a cross-sectional study. A total of 260 diabetic foot patients in the Diabetic Foot Clinic at the National Center for Diabetes, Endocrinology and Genetics (NCDEG), Amman, Jordan, participated in the study. Sociodemographic and health data were gathered through review of medical charts and a structured questionnaire. Depression and anxiety status were also assessed. The Generalized Anxiety Disorder Scale (GAD-7) was used to screen for anxiety and the Patient Health Questionnaire (PHQ-9) was used to screen for depression. A cutoff of ≥ 10 was used for each scale to identify those who tested positive for anxiety and depression.ResultsPrevalence rate of anxiety was 37.7% and that of depression was 39.6%. Multiple logistic regression analysis showed that anxiety is positively associated with duration of diabetes of < 10 years (P = 0.01), with ≥ three comorbid diseases (P = 0.00), and HbA1c level of > 7% (P = 0.03). Multiple logistic regression analysis also showed that depression is positively associated with patients of < 50 years of age (P = 0.03), females (P = 0.01), current smokers (P = 0.01), patients with foot ulcer duration ≥ 7 months (P = 0.00), with ≥ three comorbid diseases (P = 0.00) than their counterparts.ConclusionsAnxiety and depression are widely prevalent among diabetic foot patients. Mental health status of those patients gets even worse among those suffering other comorbid diseases, which was a finding that requires special attention in the management of patients with diabetic foot.

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Female sex, young age, northern German residence, hypoglycemia and disabling diabetes complications are associated with depressed mood in the WHO-5 questionnaire – A multicenter DPV study among 17,563 adult patients with type 2 diabetes

Cited by 20 publications

References 40 publications

Impact of severe hypoglycaemia on psychological outcomes in adults with Type 2 diabetes: a systematic review

Impact of severe hypoglycaemia on psychological outcomes in adults with Type 2 diabetes: a systematic review

How psychosocial outcomes impact on the self-reported health status in type 2 diabetes patients: Findings from the Diabetes Attitudes, Wishes and Needs (DAWN) study in eastern China

Anxiety and Depression Among Adult Patients With Diabetic Foot: Prevalence and Associated Factors

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