Female Sex Hormones, Contraceptives, And Fertility Drugs

Abstract

Substances that interact with estrogen or progesterone receptors have clinical applications in hormone replacement therapy, birth control, prevention and treatment of hormone‐dependent cancer, and in stimulation of fertility. This chapter describes the specific drugs in each of these categories, and their counterparts now in clinical trials or in use experimentally, with respect to mechanism of pharmacologic action, noteworthy routes of biotransformation, structure–activity relationships, and current and future prospects for therapeutic uses. The history of discovery and current understanding of the molecular endocrinologic basis of selective estrogen receptor modulators are covered, as are mechanistic, structural, and clinical aspects of drugs that interfere with estrogen biosynthesis (aromatase inhibitors). Structural and pharmacologic aspects of environmental/dietary estrogens and progestins are also included.

Effects of Asparagus racemosus Root Extracts on Serum Lipid Profiles, Lipid Peroxidation and Superoxide Dismutase in Ovariectomized Rat

“…[35][36] Inovariectomized rats the traditional way to indicate the estrogenic potency and efficacy has been via uterotrophic effects. 37 There were no significant changes in the lipid profiles of male rats administered with the AR root powder. 38 In this study, female rats administered with the aqueous and ethanolic extracts of the AR roots also had no significant changes in their lipid and antioxidant profiles.…”