Female Sex Hormone Effects on the Vasculature: Considering the Validity of Restricting Study Inclusion to Low-Hormone Phases

Turner, Casey G; Stanhewicz, Anna E.; Wong, Brett J.

doi:10.3389/fphys.2020.596507

Cited by 11 publications

(5 citation statements)

References 60 publications

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“…Also, the small sample size in the HCT group and resulting low power may have contributed to the lack of significant differences in LH, testosterone, estrogen, FMD, and EID, and the results should be interpreted with caution. While previous research has indicated estrogen deprivation is associated with vascular dysfunction,24 estrogen did not differ significantly between groups nor was it associated with any vascular measures. This study did not account for menstrual cycle, although recent studies have shown no changes in endothelial and smooth muscle function throughout menstrual cycle phases in premenopausal women 25.…”

Section: Discussioncontrasting

confidence: 85%

The Role of Follicle-stimulating Hormone in Vascular Dysfunction Observed in Hematopoietic Cell Transplant Recipients

Roelofs¹,

Dengel²,

Wang

et al. 2021

Journal of Pediatric Hematology/Oncology

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Childhood cancer survivors who receive a hematopoietic cell transplantation (HCT) are at increased risk for folliclestimulating hormone (FSH) abnormalities, which may have a substantial negative impact on vascular function. The purpose of this study was to examine the association of vascular function with FSH in HCT recipients, non-HCT recipients and healthy controls. The study included childhood cancer survivors who were HCT recipients (n = 24) and non-HCT recipients (n = 308), and a control group of healthy siblings (n = 211) all between 9 and 18 years old. Vascular measures of carotid artery structure and function (compliance and distensibility), brachial artery flow-mediated dilation and endothelial-independent dilation were measured using ultrasound imaging. A fasting blood sample was collected to measure hormone levels. FSH was significantly higher in HCT recipients compared with non-HCT recipients and healthy controls (P < 0.01). Carotid compliance and distensibility were significantly lower in HCT and non-HCT recipients compared with healthy controls (P < 0.05). Higher FSH was associated with decreased carotid compliance (P < 0.05). This study's results suggest that higher levels of FSH in HCT recipients may result in significant reductions in vascular function compared with non-HCT recipients and healthy controls. Therefore, gonadotropin endocrine dysfunction, particularly abnormal FSH levels, may be an underlying mechanism of vascular dysfunction.

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Section: Discussioncontrasting

confidence: 85%

The Role of Follicle-stimulating Hormone in Vascular Dysfunction Observed in Hematopoietic Cell Transplant Recipients

Roelofs¹,

Dengel²,

Wang

et al. 2021

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

show abstract

“…Also, the small sample size in the HCT group and resulting low power may have contributed to the lack of significant differences in LH, testosterone, estrogen, FMD, and EID, and the results should be interpreted with caution. While previous research has indicated estrogen deprivation is associated with vascular dysfunction, 24 estrogen did not differ significantly between groups nor was it associated with any vascular measures. This study did not account for menstrual cycle, although recent studies have shown no changes in endothelial and smooth muscle function throughout menstrual cycle phases in premenopausal women.…”

Section: Discussioncontrasting

confidence: 85%

The Role of Follicle-Stimulating Hormone in Vascular Dysfunction Observed in Hematopoietic Cell Transplant Recipients

Roelofs

Dengel

Wang

et al. 2020

Preprint

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Background: Childhood cancer survivors (CCS) who receive a hematopoietic cell transplantation (HCT) are at increased risk for follicle-stimulating hormone (FSH) and luteinizing hormone (LH) abnormalities, which may have a substantial negative impact on vascular function. This study's purpose was to examine the association of vascular function with FSH and LH in HCT recipients, non-HCT recipients and healthy controls. Procedures: The study included CCS who were HCT recipients (n=24) and non-HCT recipients (n=308), and a control group of healthy siblings (n=211) all aged between 9-18 years. Vascular measures of carotid artery structure and function (compliance and distensibility), brachial artery flow-mediated dilation (FMD) and

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“…Females provided additional information pertaining to menstrual cycle and hormonal contraception use. Females were not restricted to test during a particular phase of the menstrual cycle as findings pertaining to the effect of menstrual cycle on vascular function in females are limited and equivocal [26]. Furthermore, we did not assess menopausal status and exclude peri-or menopausal women from participating in the study.…”

Section: Experimental Protocolmentioning

confidence: 99%

The Impact of Fitness Status on Vascular and Baroreceptor Function in Healthy Women and Men

et al. 2021

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Background: Chronic endurance exercise training elicits desirable physiological adaptations in the cardiovascular system. The volume of exercise training required to generate healthy adaptations is unclear. This study assessed the effects of differing exercise training levels on arterial stiffness, compliance, and autonomic function. Methods: Eighty healthy adults (38.5 ± 9.7 years; 44% female) defined as endurance-trained (ET, n = 29), normally active (NA, n = 27), or inactive (IN, n = 24) participated. Cardiovascular markers, including hemodynamics, large arterial compliance and small arterial compliance (LAC and SAC), carotid-femoral pulse wave velocity (PWV), and spontaneous baroreceptor sensitivity (BRS) were assessed. Results: ET showed significantly greater LAC values (21.4 ± 6.5) than NA (16.9 ± 2.5; p = 0.002) and IN (14.7 ± 3.2 mL × mm Hg × 10; p = 0.028). Values for SAC and BRS were significantly higher in ET than IN (p < 0.001 and p = 0.028, respectively), but not NA. Compared to IN, PWV values for ET and NA were significantly lower (p < 0.003). After adjusting for covariates (age, sex, and SBP), significant associations with cardiovascular fitness status were noted for all markers but BRS. Conclusion: Endurance exercise increases LAC likely due to high-volume training; however, lower volumes of physical activity may be sufficient to positively benefit vascular health overall.

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Female Sex Hormone Effects on the Vasculature: Considering the Validity of Restricting Study Inclusion to Low-Hormone Phases

Cited by 11 publications

References 60 publications

The Role of Follicle-stimulating Hormone in Vascular Dysfunction Observed in Hematopoietic Cell Transplant Recipients

The Role of Follicle-stimulating Hormone in Vascular Dysfunction Observed in Hematopoietic Cell Transplant Recipients

The Role of Follicle-Stimulating Hormone in Vascular Dysfunction Observed in Hematopoietic Cell Transplant Recipients

The Impact of Fitness Status on Vascular and Baroreceptor Function in Healthy Women and Men

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