Female recruits sustaining stress fractures during military basic training demonstrate differential concentrations of circulating IGF-I system components: A preliminary study

Strohbach, Cassandra A.; Scofield, Dennis E.; Nindl, Bradley C.; Centi, Amanda; Yanovich, Ran; Evans, Rachel; Moran, Daniel S.

doi:10.1016/j.ghir.2012.04.007

Cited by 21 publications

(17 citation statements)

References 52 publications

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“…In addition, reduced concentrations of IGF-I have been associated with fracture risk in women ( 64 , 125 ). Only a few studies have examined the use of biomarkers to assess stress fracture risk, none of which have identified a single set of bone turnover biomarkers that could be used for stress fracture prediction ( 124 , 147 ). However, Strohbach et al ( 124 ) did report that serum IGF-I was decreased in subjects who sustained a stress fracture when compared with their noninjured control subject.…”

Section: Biomarkers Of Injury Status and Riskmentioning

confidence: 99%

“…Only a few studies have examined the use of biomarkers to assess stress fracture risk, none of which have identified a single set of bone turnover biomarkers that could be used for stress fracture prediction ( 124 , 147 ). However, Strohbach et al ( 124 ) did report that serum IGF-I was decreased in subjects who sustained a stress fracture when compared with their noninjured control subject. The results of these few studies as well as an improved understanding of the female athlete triad will allow for the continued exploration of biomarkers that could potential identify individuals at risk of stress fracture development.…”

Section: Biomarkers Of Injury Status and Riskmentioning

confidence: 99%

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Biomarkers in Sports and Exercise: Tracking Health, Performance, and Recovery in Athletes

Lee

Fragala

Kavouras

et al. 2017

Journal of Strength and Conditioning Research

248

245

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Lee, EC, Fragala, MS, Kavouras, SA, Queen, RM, Pryor, JL, and Casa, DJ. Biomarkers in sports and exercise: tracking health, performance, and recovery in athletes. J Strength Cond Res 31(10): 2920–2937, 2017—Biomarker discovery and validation is a critical aim of the medical and scientific community. Research into exercise and diet-related biomarkers aims to improve health, performance, and recovery in military personnel, athletes, and lay persons. Exercise physiology research has identified individual biomarkers for assessing health, performance, and recovery during exercise training. However, there are few recommendations for biomarker panels for tracking changes in individuals participating in physical activity and exercise training programs. Our approach was to review the current literature and recommend a collection of validated biomarkers in key categories of health, performance, and recovery that could be used for this purpose. We determined that a comprehensive performance set of biomarkers should include key markers of (a) nutrition and metabolic health, (b) hydration status, (c) muscle status, (d) endurance performance, (e) injury status and risk, and (f) inflammation. Our review will help coaches, clinical sport professionals, researchers, and athletes better understand how to comprehensively monitor physiologic changes, as they design training cycles that elicit maximal improvements in performance while minimizing overtraining and injury risk.

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Section: Biomarkers Of Injury Status and Riskmentioning

confidence: 99%

Section: Biomarkers Of Injury Status and Riskmentioning

confidence: 99%

Biomarkers in Sports and Exercise: Tracking Health, Performance, and Recovery in Athletes

Lee

Fragala

Kavouras

et al. 2017

Journal of Strength and Conditioning Research

248

245

View full text Add to dashboard Cite

show abstract

“…The study duration ranged from 3 months to 6.5 years. Two studies were conducted in the United States, 5,7 1 in Greece, 6 4 in Israel, 13,28,29,37 and 2 in Finland. 34,41 Five studies included solely male participants, 6,13,28,34,41 3 studies included solely female participants, 5,29,37 and 1 study included both male and female participants.…”

Section: Study Characteristicsmentioning

confidence: 99%

Serum 25-Hydroxyvitamin D Levels and Stress Fractures in Military Personnel

et al. 2014

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“…Several studies have investigated serum levels of 25(OH)D and iPTH in patients with stress fractures without conclusive data . In this study, BTM differed between the case group and the control population.…”

Section: Discussionmentioning

confidence: 84%

Bone Stress Injuries Are Associated With Differences in Bone Microarchitecture in Male Professional Soldiers

Schanda

Kocijan

Resch

et al. 2019

Journal Orthopaedic Research

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Bone stress injuries are commonly due to repetitive loading, as often described in competitive athletes or military recruits. The underlying pathophysiology of bone stress injuries is multifactorial. The present cross-sectional study investigated (i) cortical and trabecular bone microstructure as well as volumetric bone mineral density in subjects with bone stress injuries at the tibial diaphysis, measured at the distal tibia and the distal radius by means of high-resolution peripheral quantitative computed tomography (CT), (ii) areal bone mineral density using dual-energy X-ray absorptiometry as well as calcaneal dual X-ray absorptiometry and laser, and (iii) the influence on bone turnover markers of formation and resorption at the early phase after injury. A total of 26 Caucasian male professional soldiers with post-training bone stress injury at the tibial diaphysis were included (case group). A total of 50 male, Caucasian professional soldiers from the same military institution served as controls (control group). High-resolution peripheral quantitative CT revealed a higher total area at the radius within the case group. Cortical bone mineral density was reduced at the radius and tibia within the case group. The trabecular number and trabecular thickness were reduced at the tibia in the case group. The trabecular network was more inhomogeneous at the radius and tibia within the case group. Calcaneal dual X-ray absorptiometry and laser was significantly reduced in the case group. This study quantified differences in bone microstructure among otherwise healthy individuals. Differences in bone microarchitecture may impair the biomechanical properties by increasing the susceptibility to sustain bone stress injuries.

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Female recruits sustaining stress fractures during military basic training demonstrate differential concentrations of circulating IGF-I system components: A preliminary study

Cited by 21 publications

References 52 publications

Biomarkers in Sports and Exercise: Tracking Health, Performance, and Recovery in Athletes

Biomarkers in Sports and Exercise: Tracking Health, Performance, and Recovery in Athletes

Serum 25-Hydroxyvitamin D Levels and Stress Fractures in Military Personnel

Bone Stress Injuries Are Associated With Differences in Bone Microarchitecture in Male Professional Soldiers

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