Female primary urethral carcinoma: A rare case report

Pratama, Mochammad Ecky; Ismy, Jufriady; Kamarlis, Reno Keumalazia; Mauny, Muhammad Puteh

doi:10.1016/j.ijscr.2021.106100

Cited by 6 publications

(6 citation statements)

References 12 publications

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“…Most women (>70%) are symptomatic when diagnosed [ 4 ]. Symptoms include urinary complaints (dysuria, hematuria, urinary retention), pain (dyspareunia, perineal), or an urethral/meatal mass [ 5 ]. Half of symptomatic patients, especially females, present with locally advanced disease (≥cT2 or cN+) [ 3 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Half of symptomatic patients, especially females, present with locally advanced disease (≥cT2 or cN+) [ 3 , 4 ]. Tumoral extension starts from periurethral tissues toward the regional lymph nodes which are common sites of regional metastasis and over 30% of patients have clinically palpable lymph nodes at the time of diagnosis, that are metastatic in >90% of cases [ 5 ]. The tumoral staging starts during physical examination with urethra palpation, speculum visualization in women, and inguinal lymph node palpation in both genders [ 1 – 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…The tumoral staging starts during physical examination with urethra palpation, speculum visualization in women, and inguinal lymph node palpation in both genders [1][2][3]. The definitive diagnosis relies on urethrocystoscopy to obtain cold biopsies and/or transurethral resection to evaluate tumor location, extension, and histology with exclusion of concomitant bladder tumor [5]. Sensitivity of the urinary cytology in biopsy-proven PUC only reaches 59% [4].…”

Section: Case Reports In Oncologymentioning

confidence: 99%

“…Other factors impairing survival include older age (>65 years), race, tumoral size, and non-squamous histology [1][2][3][4]. Management of PUC in current literature depends on initial tumor stage, although treatment consensus is lacking because of its low incidence [1,[3][4][5][6]18]. In localized PUC, surgery (radical urethrectomy or urethra-sparing surgery) is the mainstay of treatment with 73% of 5-year OS [1].…”

Section: Case Reports In Oncologymentioning

confidence: 99%

“…The few established risk factors in females include human papilloma virus (HPV) 16/18 infection [ 3 ]. Clinical presentation is variable, but up to 30% of palpable lymph nodes are found at diagnosis and are metastatic in >90% of cases [ 4 , 5 ]. The overall prognosis of PUC remains poor with no established therapeutic consensus due to the disease’s rarity.…”

Section: Introductionmentioning

confidence: 99%

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Advanced Female Primary Urethral Carcinoma with Nodal Extension Managed with Exclusive Use of Chemoradiotherapy: Report of a Case and Review of the Relevant Current Literature

Al Barajraji,

Holz,

Moussa

et al. 2023

Case Rep Oncol

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Primary urethral carcinoma (PUC) is a rare disease with frequent nodal metastasis at the time of diagnosis. Few risk factors have been established and overall prognosis remains poor. As of now, no clear therapeutic guidelines are established and management of advanced PUC often involves surgery which can have negative functional and psychological outcomes for the patient. Few authors have already reported the use of chemoradiotherapy alone to avoid surgery with some good short-term results. We report the case of a 48-year-old woman with advanced high-grade urothelial carcinoma of distal urethra associated to bilateral inguinal nodal metastasis. She was similarly and successfully treated using chemoradiotherapy exclusively without significant adverse effects. This experience reinforces benefits of a surgery-sparing management, when possible, as recommended in current guidelines.

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