Female predominance and X chromosome defects in autoimmune diseases

Invernizzi, Pietro; Pasini, Simone; Selmi, Carlo; Gershwin, M. Eric; Podda, Mauro

doi:10.1016/j.jaut.2009.03.005

Cited by 157 publications

(139 citation statements)

References 62 publications

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“…The same observation has been made in females with auto-immune thyroid disease and juvenile arthritis, but was not observed in systemic lupus erythemathosous and primary biliairy cirrosis (54). Two overlapping Turkish studies postulated that in 195 female SSc patients and 160 female controls skewed XCI patterns were significantly more present; 44.9% of 149 informative patients and in 8% of 124 healthy controls.…”

Section: The X Chromosome and Agesupporting

confidence: 65%

Biological Ageing Research in Systemic Sclerosis: Time to Grow up?

Broen¹,

McGlynn²,

Radstake³

et al. 2012

Systemic Sclerosis - An Update on the Aberrant Immune System and Clinical Features

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Section: The X Chromosome and Agesupporting

confidence: 65%

Biological Ageing Research in Systemic Sclerosis: Time to Grow up?

Broen¹,

McGlynn²,

Radstake³

et al. 2012

Systemic Sclerosis - An Update on the Aberrant Immune System and Clinical Features

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“…Published estimates of AI prevalence in the general population range between 3 and 10% [15][16][17] and was reported to lie between 5 and 8% within the US population [18]. The prevalence of 4.4%…”

Section: Discussionmentioning

confidence: 99%

Prevalence and clinical impact of autoimmune diseases and chronic infections in malignant lymphomas at diagnosis

et al. 2011

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There is increasing evidence for the role of chronic antigenic stimulation (CS) in the development of cancer. Clinical data, however, are rare as is the information on outcome. In this study, the occurrence of chronic infections (CI) and autoimmune diseases (AI) in patients with malignant lymphoma at diagnosis was assessed. Of 367 patients (non-Hodgkin´s lymphoma (NHL) N=297, Hodgkin´s lymphoma (HL) N=70), 9.8% (N=36) had a history of chronic antigenic stimulation (4.4% AI, 5.4% CI) at diagnosis. After a median observation time of 74.7 months, 118 patients have died. There were more male patients in this cohort.However, sex ratio among patients with chronic antigenic stimulation was skewed in favor of women (p=0.018), in particular among lymphoma patients with AI (p=0.001). NHL patients with autoimmune diseases showed a tendency to develop diffuse large B cell lymphoma (DLBCL) (8 of 12 AI+NHL patients (66.7%) vs. 100 of 266 non-CS NHL (37.6%); p=0.066).No significant difference in overall survival (OS) between CS and non-CS patients could be observed (median OS after 48 months was: CS 77.7% vs. non-CS 71.8%).In conclusion, chronic antigenic stimulation at diagnosis appears to be associated with a higher prevalence in women, in particular among patients with autoimmune disease. However, no difference in overall survival was observed. This suggests that the presence of chronic inflammatory conditions does not decisively influence the outcome of lymphoma patients.

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“…estrogen) can be partly responsible for the higher occurrence of autoimmune disorders in these patients. 34 Indeed, the estrogens have immune modulating properties, influence the innate and adaptive immune cells, antigen presentation, cytokine secretion, and generation of autoantibodies and stimulate autoreactive B-cells, promoting the escape of autoreactive cells from the mechanisms of immune tolerance. 8 A link between cardiovascular disease and lung cancer in women, through oxidative stress has been supposed by a study run on a large cohort of patients with previous atherosclerotic disease-the female patients are more sensitive to tobacco-induced carcinogenesis than men, since a higher level of lung cytochrome P4501A1 (CYP1A1) gene expression in women plays a significant role in lung DNA adduct formation and supports a higher susceptibility to lung cancer among women.…”

Section: D-roms Pat and Sat Tests And Gendermentioning

confidence: 99%

Oxidative stress, plasma/salivary antioxidant status detection and health risk factors

et al. 2017

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Reactive oxygen species (ROS) are produced by molecular oxygen as a result of physiological cell metabolism and are subdivided into 2 groups: 1) Free A B S T R A C TBackground: Oxidative stress is involved in the pathophysiology of several diseases such as cardiovascular disorders, cancer, neurodegeneration. Aims and Objectives: Our study evaluated the oxidant/antioxidant status on a cohort of healthy patients matched with some independent variables as a basic individual redox balance monitor on a disease-prevention perspective. Materials and Methods: The anecdotic, retrospective and observational study included 200 apparently healthy volunteers after formal informed consent release whose personal history and physical examination had been recorded specifically on the following items: age, previous diseases, sport activities, smoking habit, balanced/unbalanced nutrition, current absence/presence of inflammatory processes, oral health hygiene, administration of oral contraceptives or hormone replacement therapy in postmenopausal women. No drug treatment was admitted in the recruited patients, up to 6 months before the evaluation. The laboratory instruments used were Point of care FRAS 4 Evolvo (H&D, Parma, Italy) measuring the oxidative stress in plasma samples and antioxidant capacity in plasma and saliva samples. Results: Two-hundred patients were recruited. Statistically relevant differences were observed in oxidative stress-related variables, namely a significant relationship between plasma oxidative stress level and female gender (p<0.01), between saliva antioxidant level and age (p=0.01), between plasma antioxidant level and unbalanced diet (p<0.01), between plasma oxidative stress level and inflammation in the oral cavity (p=0.04), and between saliva antioxidant level and inflammation in the oral cavity (p<0.01). Conclusions: A relationship between oxidative/antioxidant status and health risk factors has been outlined in our study; the achieved data are quite helpful, in the clinical practice, providing additional information on individual general health conditions, putatively related to prevention diagnosis, prognosis, and treatment effectiveness in some specific diseases.

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Female predominance and X chromosome defects in autoimmune diseases

Cited by 157 publications

References 62 publications

Biological Ageing Research in Systemic Sclerosis: Time to Grow up?

Biological Ageing Research in Systemic Sclerosis: Time to Grow up?

Prevalence and clinical impact of autoimmune diseases and chronic infections in malignant lymphomas at diagnosis

Oxidative stress, plasma/salivary antioxidant status detection and health risk factors

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