Female Lung Cancer: Re-Analysis of National Survey of Lung Cancer in Korea, 2005

Jang, Tae Won; Kim, Young Chul; Kwon, Yong Soo; Oh, In Jae; Kim, Kyu Sik; Kim, Sun Young; Ryu, Jeong Seon; Yum, Ho Kee; Lee, Kwan Ho; Yong, Suk Joong; Lee, Chang Geol; Lee, Sang Yeub; Lee, Sung Yong; Jeong, Eun Taik; In, Kwang Ho; Jung, Maan Hong

doi:10.6058/jlc.2010.9.2.57

Cited by 4 publications

(5 citation statements)

References 23 publications

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“…A limitation of this study was possible bias in the selection of the eligible study population who had available pre-treatment serum CEA levels. In fact, the percentage of samples with a histology characteristic of adenocarcinoma was higher (73.5%) than reported in recent universal and nationwide epidemiologic data 17 , 18 . Furthermore, metastatic status was evaluated by clinical and metabolic imaging and not by pathological examination.…”

Section: Discussioncontrasting

confidence: 61%

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Serum Carcinoembryonic Antigen Levels and the Risk of Whole-body Metastatic Potential in Advanced Non-small Cell Lung Cancer

Lee¹,

Kim²,

Kang³

et al. 2014

J. Cancer

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Background: This study aimed to clarify the clinical associations between serum carcinoembryonic antigen (CEA) levels and whole-body metastatic distribution in stage IV NSCLC patients.Methods: This study analyzed 377 eligible patients between June 2007 and December 2012. All patients enrolled in the study were newly diagnosed with stage IV NSCLC and had records of pre-treatment serum CEA levels. The serum CEA levels were categorized as normal (< 5 ng/ml) or abnormal (≥ 5 ng/ml) to reveal clinically correlated factors with abnormal serum CEA levels.Results: The median age of the study cohort was 65 years old (range, 30-94), and 236 (62.6%) patients were male. Two hundred seventy-seven (73.5%) patients had tumors with a histology that is consistent with adenocarcinoma. The median serum CEA value was 8.2 ng/ml (range, 0.1-2872.7), and 218 (57.8%) patients had abnormal serum CEA levels. In multivariate analysis, abnormal serum CEA levels had statistically strong associations with non-squamous cell histology (P=0.002), bone (P=0.001), and brain metastases (P=0.005); and were also closely correlated with positive metastatic LN status (P=0.083) and pulmonary metastasis (P=0.065). Very high serum CEA levels (≥ 100 ng/ml) were additionally correlated with abdominal/pelvic metastasis (P < 0.001).Conclusions: Our findings suggested that abnormal serum CEA levels were strongly correlated with increased whole-body metastatic potential in advanced NSCLC. The results provided evidence for future exploratory anti-CEA targeting and intensive systemic assessment in advanced NSCLC patients with abnormal serum CEA levels.

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Section: Discussioncontrasting

confidence: 61%

“…In fact, the percentage of samples with a histology characteristic of adenocarcinoma was higher (73.5%) than reported in recent universal and nationwide epidemiologic data 17, 18. Furthermore, metastatic status was evaluated by clinical and metabolic imaging and not by pathological examination.…”

Section: Discussionmentioning

confidence: 76%

Serum Carcinoembryonic Antigen Levels and the Risk of Whole-body Metastatic Potential in Advanced Non-small Cell Lung Cancer

Lee¹,

Kim²,

Kang³

et al. 2014

J. Cancer

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“…According to this review, age, gender, PS, histology, and hemoglobin level were the most commonly reported prognostic factors in nonoperable stages of NSCLC12. Female patients with lung cancer have a longer survival period than do males13, as reported in a survey of patients in Korea2,11, female patients showed a better prognosis than those of male in our study. Similarly, the most common histologic type in female patients in the present study was adenocarcinoma (60%), and most female patients were nonsmokers (76%).…”

Section: Discussionsupporting

confidence: 71%

“…Likewise, our data suggest a higher incidence of squamous cell carcinoma (33.6%) than of adenocarcinoma (32.8%). These results were thought to be associated with age10,11 and gender2,11. The proportion of histologic types of cancer other than adenocarcinoma, such as squamous cell carcinoma, increased with age.…”

Section: Discussionmentioning

confidence: 96%

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Clinical Features and Prognostic Factors in Elderly Koreans with Advanced Non-Small-Cell Lung Cancer in a Tertiary Referral Hospital

Kim

Lee

et al. 2013

Tuberc Respir Dis

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BackgroundMore than half of cases for advanced non-small-cell lung cancer (NSCLC) occur in elderly patients with a median age at diagnosis of 70 years. The aim of our study was to examine the clinical features and prognostic factors contributing to mortality in elderly patients with advanced NSCLC.MethodsFollowing a retrospective review of clinical data, 122 patients aged 70 years and over with a histopathological diagnosis of locally advanced (stage IIIB, n=32) and metastatic (stage IV, n=90) NSCLC between 2005 and 2011 were enrolled.ResultsThe median age was 76 years (interquartile range, [IQR], 72-80 years), and 85 (70%) patients were male. Fifty-seven (46%) patients had never smoked, and 17 (19%) were in a malnourished state with a body mass index (BMI) of <18.5 kg/m2. The initial treatments included chemotherapy (40%) and radiotherapy (7%), but 57% of the patients received supportive care only. The 1-year survival rate was 32%, and the 3-year survival rate was 4%, with a median survival duration of 6.2 months (IQR, 2.5-15.3 months). Male gender (hazard ratio [HR], 2.2; 95% confidence interval [CI], 1.3-3.9; p=0.005), low BMI (HR, 2.3; 95% CI, 1.3-3.9; p=0.004), and supportive care only (HR, 1.9; 95% CI, 1.2-2.9; p=0.007) were independent predictors of shorter survival based on a Cox proportional hazards model.ConclusionElderly patients with advanced NSCLC had a poor prognosis, particularly male patients, those with a low BMI, and those who received supportive care only.

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Korean Society of Thoracic Radiology Guideline for Lung Cancer Screening with Low-Dose CT

Lee

Kim

et al. 2012

J Korean Soc Radiol

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Female Lung Cancer: Re-Analysis of National Survey of Lung Cancer in Korea, 2005

Cited by 4 publications

References 23 publications

Serum Carcinoembryonic Antigen Levels and the Risk of Whole-body Metastatic Potential in Advanced Non-small Cell Lung Cancer

Serum Carcinoembryonic Antigen Levels and the Risk of Whole-body Metastatic Potential in Advanced Non-small Cell Lung Cancer

Clinical Features and Prognostic Factors in Elderly Koreans with Advanced Non-Small-Cell Lung Cancer in a Tertiary Referral Hospital

Korean Society of Thoracic Radiology Guideline for Lung Cancer Screening with Low-Dose CT

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