Female genital tuberculosis: a clinicopathological study

Desai, Rathnamala M; Kumar, Sanjiv; Brindini, Usha

doi:10.18203/2320-1770.ijrcog20162665

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…Menstrual complain in the form of menstrual irregularities 22.6% and post-menopausal bleeding 11.3% were present in considerable number of patients. The study findings were almost similar with Deshai RM et al 23 where 48% women had primary infertility and 12% had secondary infertility. Farhana et al 24 had shown that infertility was the most common presenting complaint in 59.77% of patients including primary and secondary types, that was slightly lower than our study findings.…”

Section: Discussionsupporting

confidence: 89%

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Evaluation of culture, molecular assay (TB-PCR), GeneXpert system and histopathology for detection of genital tuberculosis

Das¹,

Mahata

Gupta³

2022

PJMS

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Female genital tuberculosis (FGTB) has a crucial role in many gynaecological complaint and delay in diagnosis can cause irreversible damages. The new diagnostic technique GeneXpert system is accurate and rapid test can make paradigm shift in FGTB treatment. The aim of the study to estimate efficacy of different tests i.e. AFB BACTEC culture, molecular assay (TB-PCR) and histopathology in comparison to GeneXpert system to detect FGTB. The prospective observational study was conducted in between January, 2018 and June, 2019. Randomly selected total 62 patients were put under all four diagnostic tests from endometrial sampling. The positivity of genital TB and efficacy of the tests were compared with test result of GeneXpert assay.In our study, out of 62 patients, most commonly 33.9% were each from age group of 21-30 and 31-40 years i.e. reproductive ages, 45.2% were overweight, primary infertility of 48.4% patients were predominant symptomatology. Overall positivity by GeneXpert test was 21% (3/62), histopathology 8.1% (5/62), AFB BACTEC culture 12.9% (8/62) and 24.2% (15/62%) by molecular assay (TB-PCR). On evaluating against our diagnostic tests, specificity of histopathology, AFB BACTEC Culture and TB-PCR was 97.96%, 95.92% and 75.51%. The diagnostic tests were analysed by Kappa measure agreement in comparison to GeneXpert assay. The histopathology and AFB BACTEC Culture showed fair and moderate agreement respectively, but on the contrary TB-PCR have not showed any agreement with GeneXpert assay.High degree of suspicion and battery of tests needed for diagnosis of genital TB. Rapid diagnosis by GeneXpert assay may play a crucial role in TB control programme. Female genital tuberculosis (FGTB) has a crucial role in many gynaecological complaint and delay in diagnosis can cause irreversible damages. The new diagnostic technique GeneXpert system is accurate and rapid test can make paradigm shift in FGTB treatment.

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Section: Discussionsupporting

confidence: 89%

“…The study by P Kumar et al 25 reported hysteroscopy evidence of tuberculosis in 48.73% cases. In another study, Deshai RM et al 23 found 52% infertile women who underwent diagnostic hysteroscopy and laparoscopy as a part of evaluation for infertility were diagnosed to have genital TB which were higher than our study.…”

Section: Discussioncontrasting

confidence: 77%

Evaluation of culture, molecular assay (TB-PCR), GeneXpert system and histopathology for detection of genital tuberculosis

Das¹,

Mahata

Gupta³

2022

PJMS

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“…Genital tuberculosis manifests in two to twenty percent of patients with pulmonary tuberculosis. In the developed countries genital tuberculosis is the causative factor in 1% of infertile women, whereas in India genital tuberculosis is the causative factor in 18% of infertile women [10] .…”

Section: Resultsmentioning

confidence: 99%

“…Laparoscopy and laparoscopy-directed biopsy are useful in the diagnosis of tubercular salpingitis. Endometrial TB-PCR is a useful tool for the diagnosis of genital tuberculosis [10] . The use of gene Xpert has been advocated by the world health organization for the detection of Mycobacterium tuberculosis and rifampicin susceptibility.…”

Section: ~ 3 ~mentioning

confidence: 99%

Clinicopathological Study of Female Genital Tuberculosis in a Tertiary Care Hospital

Sharma¹,

Gandotra²

2021

Int. J. Clin. Obstet. Gynaecol.

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Background: This study aimed to describe the various clinical presentations of female genital tuberculosis and study the different methods of diagnosis and treatment. Materials and Methods: This retrospective study was conducted in the postgraduate department of obstetrics and gynaecology, GMC Jammu from January 2018 to January 2020. Results: Genital tuberculosis was diagnosed in 28 females over 3 years. The majority of the women (40.6%) belonged to the age group 21-29 years. Most of the women (46 %) presented with infertility followed by secondary amenorrhea (32%). 16 females who underwent diagnostic hysterolaparoscopy as a part of evaluation for infertility were diagnosed to have genital tuberculosis. Endometrial samples were sent in all cases and CBNAAT was the most valuable tool showing positive results in about 39.28% of cases. All cases were treated with anti-tubercular drugs. Conclusion: Female genital tuberculosis is an underestimated disease mainly due to its asymptomatic nature and lack of sensitive tests. Social, familial, ethical issues continue to haunt the clinician in addition to the clinical challenges faced with a case of female genital tuberculosis.

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“…Other symptoms in their studies included fever, ascites, irregular vaginal bleeding, oligomenorrhoea, chest pain and pain in the flanks [12]. Infertility as the main presenting feature in genital tuberculosis was reported by many authors [5,7,[12][13][14][15][16][17][18][19][20][21][22][23][24]. Ovarian presentation with raised CA125 and therefore mimicry of ovarian cancer is a common way of presentation [25][26][27].…”

Section: Case Reportmentioning

confidence: 99%

Genital Tract Tuberculosis in a 42-year Female Masquerading as Ovarian Malignancy

Ebughe

Ugbem

Omoronyia

2019

IJTDH

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Female genital tuberculosis is one the known causes of infertility in the tropics. The symptom complex are diverse and it is one of the known causes of pyrexia of unknown origin. Instances of mimicry of ovarian cancer with raised CA125, have been reported. We present a case report in a 42-year-old woman with abdominal pain and progressive abdominal pain of 3 weeks durations, who had confounding symptom of raised CA125, forcing a presumptive diagnosis of ovarian cancer. She had exploratory total abdominal hysterectomy (TAH). The surgical findings and histopathological diagnosis were suggestive of tuberculosis, for which she is undergoing treatment and showing remarkable improvement.

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Female genital tuberculosis: a clinicopathological study

Cited by 4 publications

References 9 publications

Evaluation of culture, molecular assay (TB-PCR), GeneXpert system and histopathology for detection of genital tuberculosis

Evaluation of culture, molecular assay (TB-PCR), GeneXpert system and histopathology for detection of genital tuberculosis

Clinicopathological Study of Female Genital Tuberculosis in a Tertiary Care Hospital

Genital Tract Tuberculosis in a 42-year Female Masquerading as Ovarian Malignancy

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