Female Genital System

Davis, Brian; Harleman, Johannes H.; Heinrichs, Martin; Maekawa, Akihiko; McConnell, R.F.; Reznik, G; Tucker, Martha R.

doi:10.1007/978-3-662-07973-7_7

Cited by 7 publications

(10 citation statements)

References 9 publications

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“…5 Alison et al (1990), 31 Davis et al (1999), 32 Davis et al. (2001), 39 Dixon et al (1999), 112 Lewis (1987), 115 Long et al (2001), 133 Montgomery and Alison (1987)…”

Section: Morphologymentioning

confidence: 99%

“… 32 Davis et al (2001), 39 Dixon et al (1999), 116 Maekawa (1990), 131 Miwa et al (1987), 147 Nielsen et al (1976), 163 Rehm et al (1984), 174 Serov et al (1973), 180 Sobis (1987c)…”

Section: Morphologymentioning

confidence: 99%

“…8 Anisimov and Nikonov (1990), 31 Davis et al (1999), 32 Davis et al (2001), 51 Frith and Ward (1988), 60 Goodman and Hildebrandt (1987c), 68 Greaves and Faccini (1984), 109 Leininger and Jokinen (1990), 181 Squire et al (1978), 197 Turusov et al. (1994)…”

Section: Morphologymentioning

confidence: 99%

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Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System

Alison²,

et al. 2014

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the female reproductive tract of laboratory rats and mice, with color photomicrographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. There is also a section on normal cyclical changes observed in the ovary, uterus, cervix and vagina to compare normal physiological changes with pathological lesions. A widely accepted and utilized international harmonization of nomenclature for female reproductive tract lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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“…5 Alison et al (1990), 31 Davis et al (1999), 32 Davis et al. (2001), 39 Dixon et al (1999), 112 Lewis (1987), 115 Long et al (2001), 133 Montgomery and Alison (1987)…”

Section: Morphologymentioning

confidence: 99%

“… 32 Davis et al (2001), 39 Dixon et al (1999), 116 Maekawa (1990), 131 Miwa et al (1987), 147 Nielsen et al (1976), 163 Rehm et al (1984), 174 Serov et al (1973), 180 Sobis (1987c)…”

Section: Morphologymentioning

confidence: 99%

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Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System

Alison²,

et al. 2014

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“…These occurred generally within dilated residual ducts (cysts), and the epithelium was usually similar to that described as proliferative (Figures 8 and 9). Many of the proliferative papillary lesions were within the scope of morphology as described for papillary cystadenoma (5,6,8), and could have been diagnosed as such by those criteria. One mouse in the 24-month group had a unilateral, 1-3-cm nodule diagnosed as a papillary cystademona.…”

Section: -24-month-old Micementioning

confidence: 99%

“…Rete cysts are also described as increasing in incidence with age. Epithelial (tubular and tubulostromal) hyperplasia within the ovary is characterized by elongated tubules within the ovary, and the origin has been ascribed by some to germinal epithelium or mesothelium (5,6). These authors identify the surface epithelium as the origin of epithelial tumors of the ovary, but indicate that cystic/papillary hyperplastic lesions may originate in either the surface epithelium or rete.…”

Section: Introductionmentioning

confidence: 99%

Apparent Mesonephric Duct (Rete Anlage) Origin for Cysts and Proliferative Epithelial Lesions in the Mouse Ovary

Long

2002

Toxicol Pathol

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Ovaries and adjacent parovarian (mesovarial) tissues of CD-1 mice of various ages were examined to characterize cystic and proliferative epithelial lesions of the ovary and parovarian tissues. Ovaries and adjacent tissues from 6 mice each at approximately 3 and 8 months of age were processed for light microscopy and step-sections (50-l intervals) of the entire tissue were examined. Tissues were collected from 40 mice each at 16 through 24 months of age and 3 step sections per mouse were examined. Mesonephri c duct remnants were found in all mice at 3 and 8 months. Ducts were usually in the mesovarial adipose tissue and near or within the ovarian hilus and were often loosely associated with smooth muscle of the mesovarial ligament. The epithelium of the ducts varied from low cuboidal to columnar, occasional individual cells were ciliated, and small papillary con gurations of epithelium were occasionally present. Ducts were dilated ( > 1 mm) more often in mice at 8 months compared to 3 months, and some were continuous with cystic spaces within the ovaries. As mice aged (16-24 months), dilation and cystic change in ducts and associated compression of ovarian tissue away from the ovarian hilus became common. The epithelium of dilated ducts was generally attened, but foci of cuboidal to columnar epithelium and/or occasional ciliated cells were present. Many ducts contained foci of hyperplastic and/or hypertrophic epithelium, and papillary projections of epithelium were occasionally found. Some of the latter lesions were consistent with a diagnosis of papillary cystadenoma. Hyperplasia of associated bromuscular stroma was limited to a few apparently extraovarian ducts. The results of this study indicate that remnant mesonephric ductular structures are common in and adjacent to the ovaries of CD-1 mice. As mice age, these ducts become dilated and, in some, the epithelium becomes hyperplastic and /or hyperptrophic . These mesonephri c duct remnants appear to be a common source of ovarian and parovarian cyts cysts and epithelial neoplasms of the ovary in mice.

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