Female Gender as a Risk Factor for Transient Post‐Thyroidectomy Hypocalcemia

Sands, Noah; Payne, Richard J.; Côté, Valérie; Hier, Michael P.; Black, Martin J.; Tamilia, Michael

doi:10.1177/0194599811414511

Cited by 59 publications

(54 citation statements)

References 18 publications

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“…Indeed, patients in group B showed 4 h-iPTH levels significantly lower (both as an absolute value and percent decline) than patients in group A. False-negative results have been interpreted as expression of the multifactorial origin of postoperative hypocalcemia. Many factors have been associated with increased risk of hypocalcemia not related to hypoparathyroidism, including old age, female sex, Graves' disease, and, more recently, 25OH-VD deficiency [47,48]. The present series does not confirm such findings since no difference was found among the three groups of patients with respect to age, sex, and preoperative iPTH, 25OH-VD, and serum calcium levels ( Table 2).…”

Section: Discussioncontrasting

confidence: 66%

Combining Early Postoperative Parathyroid Hormone and Serum Calcium Levels Allows for an Efficacious Selective Post‐thyroidectomy Supplementation Treatment

et al. 2012

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Background Optimal treatment protocol to prevent symptomatic hypocalcemia following total thyroidectomy is still matter of debate. We prospectively evaluated the efficacy of a selective supplementation protocol based on both early postoperative intact parathyroid hormone (iPTH) and serum calcium levels. Methods Two hundred thirty consecutive patients were divided in three different groups of treatment according to iPTH levels 4 h after total thyroidectomy (4 h‐iPTH) and serum calcium levels in the first postoperative day (1PO‐Ca): group A (4 h‐iPTH > 10 pg/ml, 1PO‐Ca ≥ 8.5 mg/dl), no treatment; group B (4 h‐iPTH > 10 pg/ml, 1PO‐Ca < 8.5 mg/dl), oral calcium (OC) 3 g per day; and group C (4 h‐iPTH ≤ 10 pg/ml), OC 3 g + calcitriol (VD) 1 μg per day. Development of biochemical and/or symptomatic hypocalcemia was evaluated. Results Fifty‐nine patients (25.6%) had subnormal 4 h‐iPTH levels (≤10 pg/ml) (group C). Among patients with normal 4 h‐iPTH levels, 25 (10.9%) had subnormal 1PO‐Ca (<8.5 mg/dl) (group B). The remaining 146 patients (63.5%) had normal 4 h‐iPTH and 1PO‐Ca levels (group A). One patient in group A, 2 in group B, and 18 in group C developed biochemical hypocalcemia. Only one patient in group C experienced major symptoms. Treatment was discontinued within 1 month in all the patients in group B. At a mean follow‐up of 303 days, five patients in group C were still under supplementation treatment. Conclusion The proposed supplementation protocol seems efficacious in preventing symptomatic hypocalcemia. It could allow a safe and early discharge of most patients, thus avoiding the constraints and the costs of routine supplementation.

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Section: Discussioncontrasting

confidence: 66%

Combining Early Postoperative Parathyroid Hormone and Serum Calcium Levels Allows for an Efficacious Selective Post‐thyroidectomy Supplementation Treatment

et al. 2012

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“…Sands et al, 2011 reported a higher percentage of postthyroidectomy hypocalcemia within female (13). We failed to confirm such fact most probably due to relatively small sample size of the current survey.…”

Section: Discussioncontrasting

confidence: 61%

Parathyroid hormone and serum calcium levels measurements as predictors of postoperative hypocalcemia in total thyroidectomy

et al. 2017

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“…Therefore, we suspected that female were vulnerable to hypomagnesemia (OR = 2.238, p = 0.015) may result from high prevalence of hypomagnesemia in female patients (female vs male: 26.03% vs 16.47%). Sands concluded that Female gender as a risk factor for transient post-thyroidectomy hypocalcemia [20]. …”

Section: Discussionmentioning

confidence: 99%

Hypomagnesemia predicts postoperative biochemical hypocalcemia after thyroidectomy

et al. 2017

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BackgroundTo investigate the role of magnesium in biochemical and symptomatic hypocalcemia, a retrospective study was conducted.MethodsLess-than-total thyroidectomy patients were excluded from the final analysis. Identified the risk factors of biochemical and symptomatic hypocalcemia, and investigated the correlation by logistic regression and correlation test respectively.ResultsA total of 304 patients were included in the final analysis. General incidence of hypomagnesemia was 23.36%. Logistic regression showed that gender (female) (OR = 2.238, p = 0.015) and postoperative hypomagnesemia (OR = 2.010, p = 0.017) were independent risk factors for biochemical hypocalcemia. Both Pearson and partial correlation tests indicated there was indeed significant relation between calcium and magnesium. However, relative decreasing of iPTH (>70%) (6.691, p < 0.001) and hypocalcemia (2.222, p = 0.046) were identified as risk factors of symptomatic hypocalcemia. The difference remained significant even in normoparathyroidism patients.ConclusionsPostoperative hypomagnesemia was independent risk factor of biochemical hypocalcemia. Relative decline of iPTH was predominating in predicting symptomatic hypocalcemia.

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Female Gender as a Risk Factor for Transient Post‐Thyroidectomy Hypocalcemia

Cited by 59 publications

References 18 publications

Combining Early Postoperative Parathyroid Hormone and Serum Calcium Levels Allows for an Efficacious Selective Post‐thyroidectomy Supplementation Treatment

Combining Early Postoperative Parathyroid Hormone and Serum Calcium Levels Allows for an Efficacious Selective Post‐thyroidectomy Supplementation Treatment

Parathyroid hormone and serum calcium levels measurements as predictors of postoperative hypocalcemia in total thyroidectomy

Hypomagnesemia predicts postoperative biochemical hypocalcemia after thyroidectomy

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