“…On the other hand, insomnia (Vgontzas et al, 1998, 2001) and sleep apnea patients (Carneiro et al, 2008), who are chronically sleep-deprived, exhibit dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis and the sympathetic nervous system, the main physiological stress response systems (Joels and Baram, 2009). Chronic psychosocial stressors represent powerful sleep disrupting stimuli as can be seen in studies with divorcees (Cartwright and Wood, 1991), with people who experience lack of social support in the work environment (Gadinger et al, 2009; Nomura et al, 2009), with children and adolescents exposed to traumatic events (Charuvastra and Cloitre, 2009) and in burnout patients (Armon et al, 2008). Interestingly, women who suffer from chronic burnout and report being more anxious and having more problems to sleep also exhibit lower prolactin levels (Grossi et al, 2003), a hormone that, later in this review, will be discussed as a sleep-inducing factor under stressful situations.…”