Female and male genetic contributions to post-mating immune defence in female
            <i>Drosophila melanogaster</i>

Short, Sarah M.; Lazzaro, Brian P.

doi:10.1098/rspb.2010.0937

Cited by 79 publications

(100 citation statements)

References 38 publications

(56 reference statements)

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“…Drosophila immunity studies are somewhat divided between the two inoculation sites. In some studies pathogens are injected into the abdomen (24,26,(36)(37)(38)(39), and in others they are injected into the thorax (16,(40)(41)(42)(43), while many published papers do not report the site of infection at all. This procedural variance illustrates the general belief that site of inoculation is relatively unimportant to output phenotypes-a belief that is strongly contradicted by our current data.…”

Section: Discussionmentioning

confidence: 99%

Thorax Injury Lowers Resistance to Infection in Drosophila melanogaster

et al. 2014

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The route of infection can profoundly affect both the progression and outcome of disease. We investigated differences in Drosophila melanogaster defense against infection after bacterial inoculation into two sites-the abdomen and the thorax. Thorax inoculation results in increased bacterial proliferation and causes high mortality within the first few days of infection. In contrast, abdomen inoculation results in minimal mortality and lower bacterial loads than thorax inoculation. Inoculation into either site causes systemic infection. Differences in mortality and bacterial load are due to injury of the thorax and can be recapitulated by abdominal inoculation coupled with aseptic wounding of the thorax. This altered resistance appears to be independent of classical immune pathways and opens new avenues of research on the role of injury during defense against infection.

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Section: Discussionmentioning

confidence: 99%

Thorax Injury Lowers Resistance to Infection in Drosophila melanogaster

et al. 2014

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“…(b) Immune treatments The severity of infection on host fitness is largely pathogendependent, where different species of closely related organisms can have different impacts on host survival and reproductive success [21]. Instead of using a dense array of pathogens to determine the extent to which each species influenced male reproductive behaviour (which was logistically unfeasible), we inoculated males with lipopolysaccharide (LPS).…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, our gradient consisted of LPS . The maximum dose was set by the saturation point of LPS in insect Ringer's solution, which was 50 mg ml 21 (beyond which LPS failed to stay in solution). Therefore, six doses were constructed: 0 mg (control), 0.01, 0.1, 1.0, 10 and 50 mg of LPS.…”

Section: Methodsmentioning

confidence: 99%

The influence of male age and simulated pathogenic infection on producing a dishonest sexual signal

Copeland

Fedorka

2012

Proc. R. Soc. B.

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In recent years, studies have shown that reproductive effort decelerates in response to pathogenic infection. If infection substantially reduces a host's residual reproductive value (RRV), however, then an acceleration of effort may instead occur (e.g. terminal investment). Reproductive acceleration would theoretically allow hosts to maintain or exaggerate their sexual signal upon infection. This would create a deceptive message from the perspective of the chooser, who may unwittingly copulate with an infected mate to their detriment. Using the cricket Allonemobius socius , we assessed the potential for reduced RRV to accelerate male reproductive effort and create a dishonest signal. RRV was manipulated through male age and simulated pathogenic insult. Reproductive effort was measured as calling song energetics, mating success, latency to mate and nuptial gift size. We show that males adopted either an accelerated or decelerated reproductive strategy upon infection, and that this decision was probably mediated by RRV. Moreover, males who accelerated their effort produced a dishonest signal by increasing their song energetics while providing fewer paternal resources (i.e. smaller gifts). Our study is one of the few to document the existence of dishonest signals and relate dishonesty to a potential reduction in female fitness, underscoring the conflict inherent in sexual reproduction.

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“…This suggests that M. anisopliae infection of some dipteran species may occur more readily if conidia can germinate internally. The lower survival time in female M. domestica infected with M. anisopliae may also be due to a post-mating reduction in immune defence [38][39][40] . Only newly emerged (1-2 day old) flies were used in the transmission assay, however, sufficient mating may have occurred during this time and caused the difference in survival time.…”

Section: Accepted Articlementioning

confidence: 99%

Horizontal transmission of Metarhizium anisopliae (Hypocreales: Clavicipitacea) and the effects of infection on oviposition rate in laboratory populations of Musca domestica (Diptera: Muscidae)

Baker

Rice

Leemon

et al. 2018

Pest Management Science

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BACKGROUND RESULTSMetarhizium anisopliae was transmitted between adult M. domestica flies with 91.67% -100% mortality resulting across the three ratios of infected: non-infected flies tested (1:2, 1:5, 1:10). The mean lethal time (LT50) for female recipients mixed with infected male donor flies at the three ratios were 3.95, 4.79 and 5.65 days, respectively, whereas for male recipients mixed with infected female donors at the same ratios the LT50 were 4.98, 5.98 and 7.44 days, respectively. Infection with M.anisopliae significantly reduced the reproductive capacity of female flies during the first four days of infection with 25% less eggs oviposited by infected flies than those that were uninfected. CONCLUSIONAutodissemination among house flies and reduction in oviposition in the early stages of infection could contribute significantly to the effectiveness of M. anisopliae used in biocontrol programs.

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Female and male genetic contributions to post-mating immune defence in female Drosophila melanogaster

Cited by 79 publications

References 38 publications

Thorax Injury Lowers Resistance to Infection in Drosophila melanogaster

Thorax Injury Lowers Resistance to Infection in Drosophila melanogaster

The influence of male age and simulated pathogenic infection on producing a dishonest sexual signal

Horizontal transmission of Metarhizium anisopliae (Hypocreales: Clavicipitacea) and the effects of infection on oviposition rate in laboratory populations of Musca domestica (Diptera: Muscidae)

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