FEM simulation of tapered cap floating sleeve antenna for hepatocellular carcinoma therapy

Maini, Surita

doi:10.3109/15368378.2015.1028073

Cited by 3 publications

(6 citation statements)

References 18 publications

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“…Consistently, the percentage of cells at the S and G2/M phases was decreased in the LV‐HUS1‐transfected Bel‐7402 and HepG2 cell lines (Figure D). This variation was consistent with previous studies demonstrating that the DNA damage checkpoint causes cell cycle arrest when addressing DNA damage in cancers . Altogether, the expression of HUS1 prevented the proliferation of tumor cells during HCC development.…”

Section: Resultssupporting

confidence: 92%

“…This variation was consistent with previous studies demonstrating that the DNA damage checkpoint causes cell cycle arrest when addressing DNA damage in cancers. 5,6 Altogether, the expression of HUS1 prevented the proliferation of tumor cells during HCC development.…”

Section: Effect Of Hus1 Overexpression On Hcc Cell Viabilitymentioning

confidence: 96%

“…Currently, many strategies are available for the treatment of HCC, including hepatectomy, liver transplantation, transcatheter hepatic arterial chemoembolization (TACE), partial ablation, radiation therapy, targeted therapy, and immunotherapy . However, due to the insidious early symptoms, rapid tumor progression, and controversial strategies of combining various therapies, more than 70% of advanced HCC patients do not improve survival with the abovementioned therapies . Identifying the intracellular molecular alterations involved in HCC development and progression is crucial for understanding the mechanisms of hepatocarcinogenesis and for improving the clinical outcomes of HCC patients …”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] However, due to the insidious early symptoms, rapid tumor progression, and controversial strategies of combining various therapies, more than 70% of advanced HCC patients do not improve survival with the abovementioned therapies. [6][7][8] Identifying the intracellular molecular alterations involved in HCC development and progression is crucial for understanding the mechanisms of hepatocarcinogenesis and for improving the clinical outcomes of HCC patients. 9,10 One of the mechanisms of tumorigenesis is the abundant accumulation of intracellular DNA lesions and mutations.…”

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confidence: 99%

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HUS1 checkpoint clamp component (HUS1) is a potential tumor suppressor in primary hepatocellular carcinoma

Zhou

Zhao

Chen

et al. 2018

Molecular Carcinogenesis

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The HUS1 checkpoint clamp component (HUS1), which is a member of an evolutionarily conserved, genotoxin-activated checkpoint complex (Rad9-Rad1-Hus1 [9-1-1] complex), is involved in cell cycle arrest and DNA repair in response to DNA damage. We conducted this study to investigate the biological significances of HUS1 expression in hepatocellular carcinoma (HCC) development. The mRNA and protein expression levels of HUS1 were determined using Real-time PCR and Western blot, respectively. One hundered and twenty four paraffin sections from HCC tissues were analyzed by immunohistochemistry to assess the association between HUS1 expression and clinicopathological characteristics of patients. The Kaplan-Meier method was performed to calculate the OS and RFS curves. Cell proliferation and colony formation assays, cell migration and invasion assays and cell cycle assays were used to determine the suppressor role of HUS1 in vitro. A mouse model was used to determine the effect of HUS1 on tumorigenesis. The expression of HUS1 was significantly decreased in HCC cell lines and tissues, and low HUS1 expression was associated with poor prognosis of HCC patients. Upregulation of HUS1 expression inhibited the cell proliferation, colony formation, migration, and invasion, as well as arrested cell cycle at G0/G1 in HCC cells in vitro. Moreover, sufficient HUS1 expression inhibited the tumor growth in nude mice. Our study revealed for the first time that HUS1 is a potential tumor suppressor that might produce an antitumor effect in human HCC. Furthermore, HUS1 may serve as a prognostic indicator and could be used for therapeutic application in HCC patients.

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Section: Resultssupporting

confidence: 92%

Section: Effect Of Hus1 Overexpression On Hcc Cell Viabilitymentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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HUS1 checkpoint clamp component (HUS1) is a potential tumor suppressor in primary hepatocellular carcinoma

Zhou

Zhao

Chen

et al. 2018

Molecular Carcinogenesis

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“…The propagation and absorption of electromagnetic wave in tissue can be described by the following Maxwell's equations [58][59][60]:…”

Section: Principle Of Mwamentioning

confidence: 99%

A review of antenna designs for percutaneous microwave ablation

et al. 2021

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Microwave (MW) antenna is a key element in microwave ablation (MWA) treatments as the means that energy is delivered in a focused manner to the tumor and its surrounding area. The energy delivered results in a rise in temperature to a lethal level, resulting in cell death in the ablation zone. The delivery of energy and hence the success of MWA is closely dependent on the structure of the antennas. Therefore, three design criteria, such as expected ablation zone pattern, efficiency of energy delivery, and minimization of the diameter of the antennas have been the focus along the evolution of the MW antenna. To further improve the performance of MWA in the treatment of various tumors through inventing novel antennas, this article reviews the state-of-the-art and summarizes the development of MW antenna designs regarding the three design criteria.

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Computational Modeling of Microwave Tumor Ablation

Radmilović-Radjenović

Bošković

Radjenović

2022

Bioengineering

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Microwave ablation is recognized as a minimally invasive, fast-recovery treatment for destroying cancer cells using the heat generated by microwave energy. Despite the unquestionable benefits of microwave ablation, the interaction of the microwave applicator with the tissue may result in localized heating and damage to the surrounding tissue. The majority of the tissue damage can be removed by clarifying the conditions for their development. In addition to experimental methods, computer modeling has proven to be an effective tool for optimizing the performance of microwave ablation. Furthermore, because the thermal spread in biological tissue is difficult to measure, developing a predictive model from procedural planning to execution may have a substantial influence on patient care. The comprehension of heat transport in biological tissues plays a significant role in gaining insight into the mechanisms underlying microwave ablation. Numerical methods that enable ablation size control are required to guarantee tumor destruction and minimize damage to healthy tissues. Various values of input power and ablation time correspond to different tumor shapes ensuring the preservation of healthy tissues. The optimal conditions can be estimated by performing full three-dimensional simulations. This topical review recapitulates numerous computational studies on microwave tumor ablation. Novel areas emerging in treatment planning that exploit the advantages of numerical methods are also discussed. As an illustration, the results of the three-dimensional simulations of real liver tumors in the 3D-IRCADb-01 database are presented and analyzed. The simulation results confirm that numerical methods are very useful tools for modeling microwave tumor ablation with minimal invasiveness and collateral damage.

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FEM simulation of tapered cap floating sleeve antenna for hepatocellular carcinoma therapy

Cited by 3 publications

References 18 publications

HUS1 checkpoint clamp component (HUS1) is a potential tumor suppressor in primary hepatocellular carcinoma

HUS1 checkpoint clamp component (HUS1) is a potential tumor suppressor in primary hepatocellular carcinoma

A review of antenna designs for percutaneous microwave ablation

Computational Modeling of Microwave Tumor Ablation

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