FEM Simulation of Subintimal Angioplasty for the Treatment of Chronic Total Occlusions

Avanzini, Andrea; Battini, Davide

doi:10.1155/2018/2648910

Cited by 2 publications

(1 citation statement)

References 34 publications

(47 reference statements)

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“…The radial displacement applied to the punch and the isothermal temperature are applied according to Table 1 and this input data variety contributes in getting a wider validation spectrum. In the end, a video output of the simulation is used to calculate the inner area of the section through a custom image analysis algorithm developed from previous ones adopted for similar applications [28][29][30].…”

Section: Star Folding Modelmentioning

confidence: 99%

Modeling Approach and Finite Element Analyses of a Shape Memory Epoxy-Based Material

Battini

Avanzini

Pandini

et al. 2020

Lecture Notes in Mechanical Engineering

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A series of structurally related epoxy resins were prepared as model systems for the investigation of the shape memory response, tailoring their thermo-mechanical response and describing their strain evolution under triggering stimuli with a thermo-viscoelastic model. The shape memory behavior on epoxy resin was modeled through the definition of linear viscoelastic parameters, in combination with the general time-temperature reduction scheme. Specifically, this translates into the definition of a hyperelastic response enriched with a Prony series to implement time dependency and a William-Landel-Ferry (WLF) equation to implement temperature dependency. While the hyperelastic response parameters are found with a standard fitting procedure on compression tests, finding the correct parameters for the Prony series might be challenging. For this reason, an ad-hoc optimization process was coded in Mathworks Matlab environment: proper guess values are created and then a chain of constrained optimizers (such as genetic, particle swarm, pattern search and different nonlinear programming algorithms) with smart evolving boundaries looks for the right set of parameters. The ability to correctly predict strain history and shape transitions with a finite element model was evaluated on a case study for self-deployment of a folded tubular structure. Tubular specimens were tested and the model was used to reproduce the switching from a temporary folded six-pointed star shape to their original cylindrical shape. Overall, this approach proved to be a very effective way to simulate complex shape memory responses in time and temperature domains, for which standard Dynamic Mechanical Analyses (DMA) and uniaxial tensile or compression tests are sufficient to calibrate material parameters for Finite Element (FE) implementation.

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Section: Star Folding Modelmentioning

confidence: 99%

Modeling Approach and Finite Element Analyses of a Shape Memory Epoxy-Based Material

Battini

Avanzini

Pandini

et al. 2020

Lecture Notes in Mechanical Engineering

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Investigating Balloon-Vessel Contact Pressure Patterns in Angioplasty: In Silico Insights for Drug-Coated Balloons

Stratakos,

Antonini,

Poletti

et al. 2023

Ann Biomed Eng

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Drug-Coated Balloons have shown promising results as a minimally invasive approach to treat stenotic arteries, but recent animal studies have revealed limited, non-uniform coating transfer onto the arterial lumen. In vitro data suggested that local coating transfer tracks the local Contact Pressure (CP) between the balloon and the endothelium. Therefore, this work aimed to investigate in silico how different interventional and device parameters may affect the spatial distribution of CP during the inflation of an angioplasty balloon within idealized vessels that resemble healthy femoral arteries in size and compliance. An angioplasty balloon computational model was developed, considering longitudinal non-uniform wall thickness, due to its forming process, and the folding procedure of the balloon. To identify the conditions leading to non-uniform CP, sensitivity finite element analyses were performed comparing different values for balloon working length, longitudinally varying wall thickness, friction coefficient on the balloon-vessel interface, vessel wall stiffness and thickness, and balloon-to-vessel diameter ratio. Findings indicate a significant irregularity of contact between the balloon and the vessel, mainly affected by the balloon’s unfolding and longitudinal thickness variation. Mirroring published data on coating transfer distribution in animal studies, the interfacial CP distribution was maximal at the middle of the balloon treatment site, while exhibiting a circumferential pattern of linear peaks as a consequence of the particular balloon-vessel interaction during unfolding. A high ratio of balloon-to-vessel diameter, higher vessel stiffness, and thickness was found to increase significantly the amplitude and spatial distribution of the CP, while a higher friction coefficient at the balloon-to-vessel interface further exacerbated the non-uniformity of CP. Evaluation of balloon design effects revealed that the thicker tapered part caused CP reduction in the areas that interacted with the extremities of the balloon, whereas total length only weakly impacted the CP. Taken together, this study offers a deeper understanding of the factors influencing the irregularity of balloon-tissue contact, a key step toward uniformity in drug-coating transfer and potential clinical effectiveness.

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FEM Simulation of Subintimal Angioplasty for the Treatment of Chronic Total Occlusions

Cited by 2 publications

References 34 publications

Modeling Approach and Finite Element Analyses of a Shape Memory Epoxy-Based Material

Modeling Approach and Finite Element Analyses of a Shape Memory Epoxy-Based Material

Investigating Balloon-Vessel Contact Pressure Patterns in Angioplasty: In Silico Insights for Drug-Coated Balloons

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