Felty's syndrome. A clinical and pathological survey of 21 patients and their response to treatment.

Barnes, C. G.; Turnbull, Adam; Vernon‐Roberts, B.

doi:10.1136/ard.30.4.359

Cited by 99 publications

(47 citation statements)

References 18 publications

(17 reference statements)

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“…The recurrence of neutropenia several weeks after splenectomy may be due to activation of suppressor cells present in other organs suclh as bone marrow. Our findings therefore, may offer an explanation for the transient beneficial effects of splenectomy (29,30). It is apparent that other therapeutic modalities aimed at modulating the hyperactive suppressor cells are needed.…”

Section: Discussionmentioning

confidence: 61%

Suppressor cell-mediated neutropenia in Felty's syndrome.

Abdou¹,

NaPombejara²,

Balentine³

et al. 1978

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 61%

Suppressor cell-mediated neutropenia in Felty's syndrome.

Abdou¹,

NaPombejara²,

Balentine³

et al. 1978

J. Clin. Invest.

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“…Figure 5 illustrates the similarity in protein and immunoglobulin content of the 7 Felty's and the 8 SLE cryoglobulins. Rheumatoid factor activity (not shown) was present in all but 1 reactivity toward granulocyte nuclei when compared to the SLE patients. Complement fixation was observed with all SLE sera reactive against kidney nuclei.…”

Section: Antinuclear Antibody Studies Of Cryoglobulins and Sera In Slmentioning

confidence: 90%

“…In 1924 Felty described a syndrome that suggested to him a single pathologic process that simultaneously affected the joints, the spleen, and the blood leukocytes (1). In addition to leukopenia and splenomegaly, patients with Felty's syndrome have been characterized further by long-standing rheumatoid arthritis (RA), commonly with a paucity of active joint effusions (2).…”

Section: Cryoimmunoglobulinemia Inmentioning

confidence: 99%

Cryoimmunoglobulinemia in felty's syndrome

Weisman

Zvaifler

1976

Arthritis & Rheumatism

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Seven of 9 patients with Felty's syndrome exhibited cryoglobulins in greater amounts than found in uncomplicated RA but similar to amounts found in RA with vasculitis. Antinuclear antibodies were found in high titer in the sera and cryoglobulins of Felty's patients; when compared to SLE patients, whose sera and cryoglobulins also contained antinuclear factors, an antinuclear antibody reacting with nuclei of polymorphonuclear granulocytes appeared to be selectively concentrated in the cryoglobulins of some Felty's patients.

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“…Abnormal liver function tests were found in 8 of 12 consecutive patients with this syndrome, 4 of whom had lymphocytic infiltration of sinusoids and portal tracts and 1 macronodular cirrhosis (Blendis et al, 1970a). There have since been reports of associated portal fibrosis (Barnes et al, 1971), and cirrhosis (Ritland, 1973) in patients with Felty's syndrome. Recently, 5 patients with Felty's syndrome were described who had nodular regenerative hyperplasia of the liver (Blendis et al, 1974).…”

mentioning

confidence: 98%