Felodipine distribution in organisms of warm-blooded animals

Шорманов, В. К.; Kvachakhiya, L L

doi:10.17116/sudmed20206301147

Cited by 2 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although UV–visible spectrophotometry has the advantages of simple operation, the accuracy cannot satisfy the requirements of experiments, and the sample concentration has high requirements, which are relatively difficult to attain, and the volumetric analysis is poor in sensitivity. HPLC has high stability and specificity, low detection and quantification limits, and is suitable for the quantitative determination of trace lodipine and its related substances [ 21 , 22 ]. Emam Aml A et al [ 23 ] used HPLC to determine the content of FEL in human plasma.…”

Section: Introductionmentioning

confidence: 99%

Felodipine Determination by a CdTe Quantum Dot-Based Fluorescent Probe

Cheng

et al. 2022

Micromachines

View full text Add to dashboard Cite

In this work, a CdTe quantum dot-based fluorescent probe was synthesized to determine felodipine (FEL). The synthesis conditions, structure, and interaction conditions with FEL of CdTe quantum dots were analysed by fluorescence spectrophotometry, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), UV–visible spectroscopy, and TEM. The CdTe QD concentration was 2.0 × 10−4 mol/L. The amount of quantum dots controlled in the experiment was 0.8 mL. The controlled feeding ratio of N (Cd2+):N (Te2−):N (TGA) was 2:1:4, the heating temperature was 140 °C, the heating time was 60 min, and the pH of the QD precursor was adjusted to 11 for subsequent experiments. The UV–visible spectrum showed that the emission wavelength of CdTe quantum dots at 545 nm was the strongest and symmetric. The particle size of the synthesized quantum dots was approximately 5 nm. In the interaction of CdTe quantum dots with FEL, the FEL dosage was 1.0 mL, the optimal pH value of Tris-HCl buffer was 8.2, the amount of buffer was 1.5 mL, and the reaction time was 20 min. The standard curve of FEL was determined under the optimal synthesis conditions of CdTe quantum dots and reaction of CdTe quantum dots with FEL. The linear equation was Y = 3.9448x + 50.068, the correlation coefficient R2 was 0.9986, and the linear range was 5 × 10−6–1.1 × 10−4 mol/L. A CdTe quantum dot-based fluorescent probe was successfully constructed and could be used to determine the FEL tablet content.

show abstract

Section: Introductionmentioning

confidence: 99%