Feline spongiform encephalopathy

Grufiydd-Jones, T. J.; Galloway, P. E.; Pearson, G. R.

doi:10.1111/j.1748-5827.1992.tb01026.x

Cited by 9 publications

(5 citation statements)

References 18 publications

(10 reference statements)

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“…human BSE, kuru) [61], livestock (scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle) [62], and wildlife (chronic wasting disease (CWD) in deer, elk and moose, feline spongiform encephalopathy (FSE) in domestic and wild cats) [63, 64]. These prion diseases can be inherited, transmitted or acquired sporadically, though horizontal transmission accounts for the vast majority of natural prion infections in sheep and wildlife species [65–67].…”

Section: Biology Of Prions: Tses Vs [Het-s] Vs [Ure3] and [Psi+]mentioning

confidence: 99%

Prions are affected by evolution at two levels

Wickner

Kelly

2015

Cell. Mol. Life Sci.

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Prions, infectious proteins, can transmit diseases or be the basis of heritable traits (or both), most based on amyloid forms of the prion protein. A single protein sequence can be the basis for many prion strains/variants, with different biological properties based on different amyloid conformations, each rather stably propagating. Prions are unique in that evolution and selection work at both the level of the chromosomal gene encoding the protein, and on the prion itself selecting prion variants. Here we summarize what is known about the evolution of prion proteins, both the genes and the prions themselves. We contrast the one known functional prion, [Het-s] of Podospora anserina, with the known disease prions, the yeast prions [PSI+] and [URE3] and the transmissible spongiform encephalopathies of mammals.

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Section: Biology Of Prions: Tses Vs [Het-s] Vs [Ure3] and [Psi+]mentioning

confidence: 99%

Prions are affected by evolution at two levels

Wickner

Kelly

2015

Cell. Mol. Life Sci.

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“…Andere Ätiologien wie Ammonshornnekrose, Neoplasien oder sogar Speicherkankheiten wurden auf Grund der klinischen und neurologischen Befunde an dritte bzw. fünfte Stelle gesetzt (De Lahunta, 1983;Gruffydd-Jones et al, 1991;Oliver et al, 1997). Graber et al, 1995).…”

Section: Neuroanatomische Lokalisation Und Differentialdiagnosenunclassified

“…Blut-und Urin-Paremeter sind bei Katzen mit FSE sowie bei anderen Fällen von TSE üblicherweise nicht signifikant verändert; die Erhebung ist sind aber wichtig zum Ausschluss von metabolischen Enzephalopathien. Die Untersuchung des Liquor cerebrospinalis auf Protein-und Zellgehalt ist sehr hilfreich zum Ausschluss von Enzephalitiden; das Resultat war, wie auch bei BSE üblich, normal (Scott et al, 1990;Gruffydd-Jones et al, 1991;Wyatt et al, 1991). Abnormale Elektroenzephalogramme sind nur bei Kühen mit BSE (Scott et al,1989) und Schafen mit Scrapie (Strain et al, 1986) beschrieben worden.…”

Section: Diskussionunclassified

“…Dieses könnte eine Erklärung dafür sein, warum bisher trotz recht konstanter Untersuchungszahlen an Katzen noch keine FSE-Fälle diagnostiziert worden sind. In England stieg die Anzahl der Verdachts-und der bestätigten FSE-Fälle in den ersten Monaten nach Bekanntwerden der ersten Falles deutlich an, was auf ein erhöhtes Krankheitsbewusstsein zurückgeführt worden ist (Gruffydd-Jones et al, 1991). Diese Katze hat sich mit grösster Wahrscheinlichkeit vor April 1996,das heisst vor der Änderung der Tierseuchenverordung und der Verordnung über die Entsorgung tierischer Abfälle, über das Futter infiziert.…”

Section: Diskussionunclassified

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Feline spongiforme Enzephalopathie: Erster klinischer Fall in der Schweiz

Demierre

Botteron²,

Cizinauskas³

et al. 2002

Schweizer Archiv für Tierheilkunde

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A six-year-old female Birman cat was referred to our clinic because of chronic progressive changes in behavior. Additionally, generalized vestibular ataxia and psychomotor seizures were noticed. A multifocal lesion in the forebrain as well as brainstem was suspected. Ancillary investigations such as complete blood cell count, serum biochemistry profile, urinalysis and cerebrospinal fluid examination revealed no significant abnormalities. Electroencephalography showed diffuse changes in the cortical activity. Feline spongiform encephalopathy was confirmed by histological brain examination and positive immunohistochemistry for PrPSc. This is the first time that a case of feline spongiform encephalopathy is diagnosed in Switzerland.

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“…This in turn raised concern that transmissible spongiform encephalopathies (TSEs) from other domestic species could arise and be transmissible to human or from animal to animal. Cats have been shown to be susceptible to BSE prion infection manifested as Feline spongiform encephalopathy (FSE) 7 . Transmission of BSE to dog and pig, have proven poorly successful despite several experimental and, most likely, undeliberate field attempts.…”

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confidence: 99%

Generic amyloidogenicity of mammalian prion proteins from species susceptible and resistant to prions

Nyström

Hammarström

2015

Sci Rep

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Prion diseases are lethal, infectious diseases associated with prion protein (PrP) misfolding. A large number of mammals are susceptible to both sporadic and acquired prion diseases. Although PrP is highly conserved and ubiquitously expressed in all mammals, not all species exhibit prion disease. By employing full length recombinant PrP from five known prion susceptible species (human, cattle, cat, mouse and hamster) and two species considered to be prion resistant (pig and dog) the amyloidogenicity of these PrPs has been delineated. All the mammalian PrPs, even from resistant species, were swiftly converted from the native state to amyloid-like structure when subjected to a native condition conversion assay. The PrPs displayed amyloidotypic tinctorial and ultrastructural hallmarks. Self-seeded conversion of the PrPs displayed significantly decreased lag phases demonstrating that nucleation dependent polymerization is a dominating mechanism in the fibrillation process. Fibrils from Aβ1-40, Aβ1-42, Lysozyme, Insulin and Transthyretin did not accelerate conversion of HuPrP whereas fibrils from HuPrP90-231 and HuPrP121-231 as well as full length PrPs of all PrPs efficiently seeded conversion showing specificity of the assay requiring the C-terminal PrP sequence. Our findings have implications for PrP misfolding and could have ramifications in the context of prion resistant species and silent carriers.

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Feline spongiform encephalopathy

Abstract: This paper reviews the recently recognised condition of feline spongiform encephalopathy and its importance as a neurological disorder of cats. Its possible origin and relationship to other transmissible spongiform encephalopathies are discussed.

Cited by 9 publications

References 18 publications

Prions are affected by evolution at two levels

Prions are affected by evolution at two levels

Feline spongiforme Enzephalopathie: Erster klinischer Fall in der Schweiz

Generic amyloidogenicity of mammalian prion proteins from species susceptible and resistant to prions

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